anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) Antibodies

G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Additionally we are shipping LGR4 Kits (17) and LGR4 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LGR4 55366 Q9BXB1
LGR4 107515 A2ARI4
LGR4 286994 Q9Z2H4
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Top anti-LGR4 Antibodies at antibodies-online.com

Showing 10 out of 90 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC, ELISA, WB anti-LGR4 monoclonal antibody was used diluted to 5 ?g/ml to detect LGR4 staining at the membrane of cells in various human tissues. A. Brain cerebellum. B. Pancreas islet. Strongly positive staining is noted in subsets of cells within the islets of Langerhans. Moderately positive staiing was observed in Purkinje and Golgi neurons of the cerebellum, adrenal medulla, neuroendocrine cells, hepatocytes, lung macrophages, seminiferous tubules and Leydig cells of the testis. Faintly to moderately positive staining was also observed in cardiac myocytes and renal tubules, granulocytes, and subsets of lymphocytes. Some elastin background staining is noted. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain. 25 μL Log in to see 1 to 2 Days
$135.00
Details
Human HOST_Rat (Rattus) Un-conjugated cELISA, FACS FACS analysis of BOSC23 cells using BBX-3A8. BOSC23 cells were transiently transfected with an expres-sion vector encoding either LGR4-hum (red curve), LGR4-murine (blue curve) or an irrelevant protein (control transfectant: black curve). Binding of BBX-3A8 was detected with a PE-conjugated secondary antibody. A positive signal was obtained with LGR4- hum and LGR4-mur transfected cells. SDS-PAGE analysis of purified BBX-3A8 monoclonal antibody. Lane 1: molecular weight marker, Lane 2: 2 μg of purified BBX-3A8 antibody. Proteins were separated by SDS-PAGE and stained with RAPID StainTM Reagent. 100 μg Log in to see 6 to 7 Days
$386.93
Details
Human HOST_Rat (Rattus) Un-conjugated cELISA, FACS FACS analysis of BOSC23 cells using BBX-1H1 (ABIN1720913). BOSC23 cells were transiently transfected with an expres-sion vector encoding either LGR4-hum (red curve), LGR4-murine (blue curve) or an irrelevant protein (control transfectant: black curve). Binding of BBX-3A8 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with LGR4-hum transfected cells. SDS-PAGE analysis of purified BBX-1H1 monoclonal antibody. Lane 1: molecular weight marker, Lane 2: 2 μg of purified BBX-1H1 antibody. Proteins were separated by SDS-PAGE and stained with RAPID StainTM Reagent. 100 μg Log in to see 6 to 7 Days
$386.93
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Lgr4/GPR48 Antibody [NBP1-89737] - Staining of human breast shows strong positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: Lgr4/GPR48 Antibody [NLS1631] - Analysis of anti-GPR48 / LGR4 antibody with human brain, glioblastoma. Immunohistochemistry-Paraffin: Lgr4/GPR48 Antibody [NLS1631] - Analysis of anti-GPR48 / LGR4 antibody with human brain neurons. 0.05 mL Log in to see 10 to 13 Days
$447.56
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells transfected with either RC221345 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-LGR4 antibody (ABIN2454807), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LGR4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR4. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, WB 100 μL Log in to see 7 to 9 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from Jurkat cells, using LGR4 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Hela 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded HSC3 xenograft, using LGR4, antibody at 1:250 dilution. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Mouse Un-conjugated IHC, ELISA, WB anti-LGR4 monoclonal antibody was used diluted to 5 ?g/ml to detect LGR4 staining at the membrane of cells in various human tissues. A. Brain cerebellum. B. Pancreas islet. Strongly positive staining is noted in subsets of cells within the islets of Langerhans. Moderately positive staiing was observed in Purkinje and Golgi neurons of the cerebellum, adrenal medulla, neuroendocrine cells, hepatocytes, lung macrophages, seminiferous tubules and Leydig cells of the testis. Faintly to moderately positive staining was also observed in cardiac myocytes and renal tubules, granulocytes, and subsets of lymphocytes. Some elastin background staining is noted. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain. 100 μg Log in to see 1 to 2 Days
$379.00
Details

LGR4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LGR4 Antibodies

  1. Human Monoclonal LGR4 Primary Antibody for cELISA, FACS - ABIN1720913 : Loh, Broussard, Liu, Copeland, Gilbert, Jenkins, Kolakowski: Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping. in Cytogenetics and cell genetics 2000 (PubMed)
    Show all 3 references for 1720913

  2. Human Monoclonal LGR4 Primary Antibody for cELISA, FACS - ABIN1381741 : Loh, Broussard, Kolakowski: Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor. in Biochemical and biophysical research communications 2001 (PubMed)
    Show all 2 references for 1381741

  3. Human Polyclonal LGR4 Primary Antibody for IHC, IHC (p) - ABIN4330846 : Steffen, Simon, Warneke, Balschun, Ebert, Röcken: LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma. in Virchows Archiv : an international journal of pathology 2012 (PubMed)

  4. Human Polyclonal LGR4 Primary Antibody for IHC (p) - ABIN4330842 : Shannon: IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells. in International journal of cell biology 2012 (PubMed)

More Antibodies against LGR4 Interaction Partners

Human Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) interaction partners

  1. Data (including data from studies using transgenic/knockout mice) suggest that LGR4 is key protein necessary for prostate cancer epithelial-mesenchymal transition and metastasis; LGR4 expression is elevated in human prostate cancer cell lines with metastatic potential; LGR4 silencing in prostate cancer cell line impairs cell migration and invasion without affecting cell proliferation.

  2. LGR4 is another receptor for RANKL (show TNFSF11 Antibodies). LGR4 competes with RANK to bind RANKL (show TNFSF11 Antibodies) and suppresses canonical RANK signaling during osteoclast differentiation.

  3. The LGR4 A750T variant is correlated with central obesity-related characteristics in young subjects.

  4. Lgr4 is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1 (show MAP2K1 Antibodies)/ERK1/2 (show MAPK1/3 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathways.

  5. miR (show MLXIP Antibodies)-34a gene expression upregulation inhibits ARPE-19 cell proliferation, migration and adhesion partly by suppressing LGR4 expression.

  6. Lgr4 activates Jmjd2a (show KDM4A Antibodies)/AR signaling pathway to promote interaction AR with PSA (show PLAG1 Antibodies) promoter, causing reduction of prostate cancer apoptosis and cell cycle arrest.

  7. A mechanistic understanding of RANKL (show TNFSF11 Antibodies)-LGR4 interaction has provided new insight into LGR4 mediated RANKL (show TNFSF11 Antibodies) signaling in osteoporosis and other diseases

  8. miR (show MLXIP Antibodies)-218 directly targets LGR4 and modulated the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathways in the LNCaP-IL-6 (show IL6 Antibodies)+ cells.

  9. LGR4 promotes tumorigenesis of prostate cancer via PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway.

  10. These findings suggest that aberrant RSPO3 (show RSPO3 Antibodies)-LGR4 signaling potentially acts as a driving mechanism in the aggressiveness of Keap1 (show KEAP1 Antibodies)-deficient lung ADs (show AGPS Antibodies).

Mouse (Murine) Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 (LGR4) interaction partners

  1. Data (including data from studies using transgenic/knockout mice) suggest that LGR4 is key protein necessary for prostate cancer epithelial-mesenchymal transition and metastasis; LGR4 expression is elevated in human prostate cancer cell lines with metastatic potential; LGR4 silencing in prostate cancer cell line impairs cell migration and invasion without affecting cell proliferation.

  2. LGR4 is another receptor for RANKL (show TNFSF11 Antibodies). LGR4 competes with RANK to bind RANKL (show TNFSF11 Antibodies) and suppresses canonical RANK signaling during osteoclast differentiation. Both whole-body (Lgr4(-/-)) and monocyte conditional knockout mice of Lgr4 (Lgr4 CKO) exhibit osteoclast hyperactivation (including elevation of osteoclast number, surface area, and size) and increased bone erosion.

  3. Lgr4 is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1 (show MAP2K1 Antibodies)/ERK1/2 (show MAPK1/3 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathways.

  4. RSPO (show RSPO1 Antibodies)-LGR4/5-ZNRF3 (show ZNRF3 Antibodies)/RNF43 (show RNF43 Antibodies) module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.

  5. These date indicate that hydrogen peroxide suppresses Lgr4 expression in osteoblastic cells.

  6. Lgr4 gene is regulated by BMP and is required for BMP effects on osteoblastic differentiation.

  7. Rspo1 (show RSPO1 Antibodies) and its receptor of leucine-rich repeat containing G-protein-coupled receptor 4 (Lgr4) should be a novel molecular signal in the transmission of mechanical stimuli to biological signal in the bone, and this signal should be in the upstream of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling for bone formation.

  8. Study suggests that miR (show MLXIP Antibodies)-34c contributes to osteoclast differentiation by targeting LGR4, providing novel insights into understanding the molecular mechanism underlying osteoclast differentiation.

  9. A mechanistic understanding of RANKL (show TNFSF11 Antibodies)-LGR4 interaction has provided new insight into LGR4 mediated RANKL (show TNFSF11 Antibodies) signaling in osteoporosis and other diseases

  10. LGR4 acted as a key receptor for Rspo2 (show RSPO2 Antibodies) to promote osteogenesis.

LGR4 Antigen Profile

Protein Summary

G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008

Gene names and symbols associated with LGR4

  • leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) antibody
  • leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) antibody
  • 9130225G07 antibody
  • A330106J01Rik antibody
  • A930009A08Rik antibody
  • BNMD17 antibody
  • Gpr48 antibody

Protein level used designations for LGR4

G protein-coupled receptor 48 , leucine-rich repeat-containing G-protein coupled receptor 4 , G protein-coupled receptor GPR48 , G-protein coupled receptor 48

GENE ID SPECIES
55366 Homo sapiens
451088 Pan troglodytes
107515 Mus musculus
286994 Rattus norvegicus
Selected quality suppliers for anti-LGR4 (LGR4) Antibodies
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