Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 Proteins (LGR5)

Orphan receptor. Additionally we are shipping LGR5 Antibodies (205) and LGR5 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LGR5 14160 Q9Z1P4
Rat LGR5 LGR5 299802  
LGR5 8549 O75473
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Top LGR5 Proteins at antibodies-online.com

Showing 4 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$6,052.17
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human Fc Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
Details

LGR5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
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Human , ,
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More Proteins for Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Interaction Partners

Mouse (Murine) Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. Lgr5(+) chief cells are involved in maintaining the homeostatic stem cell pool. Define Lgr5(+) chief cells as a major cell-of-origin of gastric cancer.

  2. Stem cell plasticity enables hair regeneration following Lgr5(+) cell loss.

  3. role for Lgr5(+) cancer stem cells in primary and metastatic colon cancer

  4. Data show that both the number and relative position of Paneth cells and Lgr5+ cells are important for fission.

  5. RSPO (show RSPO1 Proteins)-LGR4 (show LGR4 Proteins)/5-ZNRF3 (show ZNRF3 Proteins)/RNF43 (show RNF43 Proteins) module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.

  6. adult stem cell marker leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) is expressed in the mice nasal respiratory epithelium.

  7. Employing Lgr5-lacZ (show GLB1 Proteins) transgenic mice and Lgr5 in situ hybridization, authors found colonic epithelial stem cells (CESC) markedly more radioresistant in vivo than small intestinal crypt base columnar stem cells.

  8. Our studies show for the first time that Lgr5 is expressed in the NC cells at embryonic day 9.5 (E9.5) and is maintained during embryonic development and postnataly in the stroma of the ventral tongue, and some areas of the oral mucosa and that Lgr5+ cells participate in the maintenance of the stroma.

  9. Genetic fate-mapping of Alkaline phosphate intestinal(+) cells before or during targeted ablation of Lgr5-expressing stem cells generated numerous long-lived crypt-villus "ribbons," indicative of dedifferentiation of enterocyte precursors into Lgr5(+) stems.

  10. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.

Human Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. Lgr5(+) chief cells are involved in maintaining the homeostatic stem cell pool. Define Lgr5(+) chief cells as a major cell-of-origin of gastric cancer.

  2. LGR5-expressing fraction of CD54 (show ICAM1 Proteins)+ cells represents gastric cancer CSCs, in which LGR5 is closely associated with stemness and EMT (show ITK Proteins) core genes

  3. clathrin-mediated endocytosis inhibition of the leucine-rich G protein-coupled receptor-5 (show XCR1 Proteins) diminishes cell fitness

  4. The findings indicated that Lgr5 might contribute to the intestinal metaplasia during gastric carcinogenesis.

  5. Endometrial LGR5 is not an endogenous stem cell marker. Instead, LGR5(+) cells appear to be recruited from blood to be part of the stem cell niche at the perivascular microenvironment to activate the endogenous niche.

  6. 2 LGR5 splice variants were expressed in human intestine crypt cells; one lacked exon 5 and the other lacked exons 5-8. Only LGR5FL appeared during cell cycle arrest. The transcript variants appeared when the cell cycle was proceeding. LGR5FL-positive cells were negative for Ki-67 (show MKI67 Proteins) and were enriched after chemotherapy.

  7. Low expression of LGR5 is associated with gastric cancer.

  8. High LGR5 expression is associated with colorectal cancer.

  9. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.

  10. Lgr5 overexpression was significantly associated with deep invasion of colorectal cancer lymphnode metastasis, distant metastasis and AJCC stage

LGR5 Protein Profile

Protein Summary

Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.

Gene names and symbols associated with LGR5

  • leucine-rich repeat containing G protein-coupled receptor 5 (lgr5)
  • leucine rich repeat containing G protein coupled receptor 5 (Lgr5)
  • leucine-rich repeat containing G protein-coupled receptor 5 (LGR5)
  • FEX protein
  • GPR49 protein
  • GPR67 protein
  • GRP49 protein
  • HG38 protein
  • lgr5-a protein
  • lgr5a protein

Protein level used designations for LGR5

leucine-rich repeat-containing G protein-coupled receptor 5 , leucine-rich repeat-containing G-protein coupled receptor 5A , leucine-rich repeat-containing G-protein coupled receptor 5a , G protein-coupled receptor 49 , G-protein coupled receptor 49 , follicle expressed hormone , leucine-rich repeat-containing G-protein coupled receptor 5 , orphan G-protein coupled receptor FEX , G-protein coupled receptor 67 , G-protein coupled receptor HG38 , orphan G protein-coupled receptor HG38

GENE ID SPECIES
100526795 Xenopus laevis
14160 Mus musculus
299802 Rattus norvegicus
8549 Homo sapiens
427867 Gallus gallus
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