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Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 Proteins (LGR5)

Orphan receptor. Additionally we are shipping LGR5 Antibodies (182) and LGR5 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LGR5 14160 Q9Z1P4
Rat LGR5 LGR5 299802  
LGR5 8549 O75473
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Top LGR5 Proteins at antibodies-online.com

Showing 4 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details
Yeast Human His tag   50 μg Log in to see 8 to 11 Days
$341.00
Details
HOST_HEK-293 Cells Human Fc Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

LGR5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
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Human , ,
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More Proteins for Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Interaction Partners

Mouse (Murine) Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. Our studies show for the first time that Lgr5 is expressed in the NC cells at embryonic day 9.5 (E9.5) and is maintained during embryonic development and postnataly in the stroma of the ventral tongue, and some areas of the oral mucosa and that Lgr5+ cells participate in the maintenance of the stroma.

  2. Genetic fate-mapping of Alkaline phosphate intestinal(+) cells before or during targeted ablation of Lgr5-expressing stem cells generated numerous long-lived crypt-villus "ribbons," indicative of dedifferentiation of enterocyte precursors into Lgr5(+) stems.

  3. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.

  4. The generation of new retinal cells, including retinal neurons and Muller glia from Lgr5-expressed amacrine cells, begins in early adulthood and continues as the animal ages.

  5. Endogenous hyaluronic acid increases Lgr5(+) stem cell proliferation, crypt fission, and intestinal lengthening and that these effects are dependent on signaling through CD44 (show CD44 Proteins) and TLR4 (show TLR4 Proteins).

  6. Myh9 (show MYH9 Proteins) mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells

  7. Lgr6 (show LGR6 Proteins) and Bmi1 (show BMI1 Proteins) have roles in stem cells in the acral epithelium that participate in the long-term maintenance of sweat glands, ducts, and interadnexal epidermis, while Lgr5 has a role in rapid cycling and maintance of sweat glands only

  8. H pylori colonize and manipulate the progenitor and Lgr5(+)stem cell compartments, which alters turnover kinetics and glandular hyperplasia.

  9. These data suggest that the neonatal mammalian cochlea has some capacity for hair cell regeneration following damage alone and that Lgr5-positive cells act as hair cell progenitors in the cochlea.

  10. Positioning within the niche and levels of LGR5 expression discriminate intestinal intestinal stem and progenitor cells with different Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling activity.

Human Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) interaction partners

  1. Low expression of LGR5 is associated with gastric cancer.

  2. High LGR5 expression is associated with colorectal cancer.

  3. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.

  4. Lgr5 overexpression was significantly associated with deep invasion of colorectal cancer lymphnode metastasis, distant metastasis and AJCC stage

  5. Data suggest that targeting of leucine rich repeat containing G protein-coupled receptor 5 (LGR5) may be of therapeutic benefit for neuroblastomas.

  6. This study shows that Lgr5 can be a valuable and reliable prognostic factor of colorectal cancer progression.

  7. We conclude that overexpression of LGR5 is associated with markers of tumor aggressiveness in human papillary thyroid cancer

  8. The results suggest that trichosanthin may induce apoptosis in glioma cells by targeting LGR5 and repressing the Wnt (show WNT2 Proteins)/betabcatenin signaling pathway

  9. These findings indicate that LGR5 not only participates in carcinogenesis but also maintained stemness by activating Wnt/b-catenin signaling in breast cancer.

  10. We confirmed in a large and independent study cohort that LGR5 rs17109924 is a predictive genetic biomarker for time to recurrence in patients with colon cancer treated with 5-FU-based adjuvant chemotherapy.

LGR5 Protein Profile

Protein Summary

Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.

Gene names and symbols associated with LGR5

  • leucine-rich repeat containing G protein-coupled receptor 5 (lgr5)
  • leucine rich repeat containing G protein coupled receptor 5 (Lgr5)
  • leucine-rich repeat containing G protein-coupled receptor 5 (LGR5)
  • FEX protein
  • GPR49 protein
  • GPR67 protein
  • GRP49 protein
  • HG38 protein
  • lgr5-a protein
  • lgr5a protein

Protein level used designations for LGR5

leucine-rich repeat-containing G protein-coupled receptor 5 , leucine-rich repeat-containing G-protein coupled receptor 5A , leucine-rich repeat-containing G-protein coupled receptor 5a , G protein-coupled receptor 49 , G-protein coupled receptor 49 , follicle expressed hormone , leucine-rich repeat-containing G-protein coupled receptor 5 , orphan G-protein coupled receptor FEX , G-protein coupled receptor 67 , G-protein coupled receptor HG38 , orphan G protein-coupled receptor HG38

GENE ID SPECIES
100526795 Xenopus laevis
14160 Mus musculus
299802 Rattus norvegicus
8549 Homo sapiens
427867 Gallus gallus
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