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anti-Leucyl/cystinyl Aminopeptidase (LNPEP) Antibodies

LNPEP encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. Additionally we are shipping LNPEP Kits (20) and LNPEP Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LNPEP 240028 Q8C129
LNPEP 171105 P97629
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Top anti-LNPEP Antibodies at

Showing 10 out of 43 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB LNPEP Antibody (N-Term)  western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LNPEP antibody detected the LNPEP protein (arrow). LNPEP antibody (N-Term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the LNPEP antibody (N-Term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of HL-60 cells using LNPEP Antibody (N-Term) Cat.-No AP52510PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated Goat anti Rabbit secondary antibodies were used for the analysis. Formalin fixed, paraffin embedded Human kidney tissue stained with LNPEP Antibody (N-Term) followed by peroxidase conjugation of the secondary antibody and DAB staining. 0.4 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IF, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, IF, WB Western blot analysis of LNPEP in human lung tissue lysate with LNPEP Antibody  at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
Rat Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 8 to 10 Days
Human Rabbit Alkaline Phosphatase (AP) FACS, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL Log in to see 9 Days
Human Sheep Un-conjugated IP, WB   100 μg Log in to see 8 to 10 Days
Human Rabbit Un-conjugated FACS, IHC, ELISA, WB   200 μL Log in to see 11 to 16 Days

LNPEP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,

Rat (Rattus) ,

Human , ,
, ,
, , , , ,

Top referenced anti-LNPEP Antibodies

  1. Human Polyclonal LNPEP Primary Antibody for EIA, FACS - ABIN953199 : Georgiadou, Hearn, Evnouchidou, Chroni, Leondiadis, York, Rock, Stratikos: Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 5 references for ABIN953199

  2. Human Polyclonal LNPEP Primary Antibody for FACS, IHC (p) - ABIN654230 : Saveanu, Carroll, Weimershaus, Guermonprez, Firat, Lindo, Greer, Davoust, Kratzer, Keller, Niedermann, van Endert: IRAP identifies an endosomal compartment required for MHC class I cross-presentation. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 2 references for ABIN654230

More Antibodies against LNPEP Interaction Partners

Mouse (Murine) Leucyl/cystinyl Aminopeptidase (LNPEP) interaction partners

  1. IRAP (show IL1RN Antibodies) is more highly expressed in pro-inflammatory M1-activated macrophages.

  2. IRAP (show IL1RN Antibodies) deficiency may lead to suppression of PAI-1 (show SERPINE1 Antibodies) expression in adipocytes and upregulation of UCP-1 (show UCP1 Antibodies)-mediated thermogenesis in brown adipose tissue and increased energy expenditure to prevent the development of obesity.

  3. The current study demonstrates that deletion of the IRAP (show IL1RN Antibodies) gene protects the brain from ischemic damage

  4. IRAP (show IL1RN Antibodies)-deficient mice are less sensitive to the development of acute pentylenetetrazol-induced seizures, demonstrating that IRAP (show IL1RN Antibodies) may be involved in generalized seizure generation.

  5. requirement of IRAP (show IL1RN Antibodies) in cross-presentation extends to steady-state conventional dendritic cells (cDCs);data suggest increased recruitment of an IRAP (show IL1RN Antibodies)(+)/Rab14 (show RAB14 Antibodies)(+) compartment to Ag-containing vesicles contributes to cross-presentation efficacy of CD8 (show CD8A Antibodies)(+)cDCs

  6. These findings suggest that the IRAP (show IL1RN Antibodies) binding protein, vimentin (show VIM Antibodies), plays an important role in retention of GLUT4 (show SLC2A4 Antibodies) storage vesicles.

  7. IRAP (show IL1RN Antibodies) functions in GLUT4 (show SLC2A4 Antibodies) sorting from endosomes to GLUT4 (show SLC2A4 Antibodies)-specialized compartments.

  8. study shows the high-affinity binding site for angiotensin IV is absent in IRAP (show IL1RN Antibodies) knockout mice brain sections in parallel with loss of IRAP (show IL1RN Antibodies) immunostaining, providing irrefutable proof that IRAP (show IL1RN Antibodies) is the specific high-affinity binding site for AT(4) ligands

  9. Data suggest that the physiological significance of circulating insulin-regulated aminopeptidase during human pregnancy cannot be addressed by investigations on mice.

  10. Initial characterization of knockout mice in which IRAP/P-LAP was deleted revealed that GLUT4 protein levels were dramatically decreased in all fat and muscle tissues.

Human Leucyl/cystinyl Aminopeptidase (LNPEP) interaction partners

  1. The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP (show IL1RN Antibodies) were detected in the jejunal mucosa.

  2. Determined is the crystal structure of human IRAP (show IL1RN Antibodies) revealing a closed, four domain arrangement with a large, mostly buried cavity abutting the active site.

  3. We identified the missense variant rs2303138 (p.Ala763Thr) within the LNPEP gene associated with psoriasis.

  4. Activities of aminopeptidases N and B and insulin-regulated aminopeptidase could be useful non-invasive biomarkers of Alzheimer's disease from the earliest stages.

  5. An association between maternal common polymorphisms in LNPEP and susceptibility to preterm birth was observed.

  6. The genetic variation in LNPEP (vasopressinase) is associated with 28-day mortality in septic shock and is associated with biologic effects on vasopressin (show AVP Antibodies) clearance and serum sodium regulation

  7. investigation of domain structure of IRAP (show IL1RN Antibodies); catalytic domains; inhibitor-binding domains; zinc binding sites

  8. Although PLAP (show ALP Antibodies) has the necessary enzymatic properties to participate in generating or destroying major histocompatibility class I-presented peptides, its trimming behavior during antigen processing is distinct from that of ERAP1 (show ERAP1 Antibodies).

  9. The probable involvement of P-LAP in trophoblast invasion and development of preeclampsia.

  10. Identification of a tankyrase-binding motif in this protein

Cow (Bovine) Leucyl/cystinyl Aminopeptidase (LNPEP) interaction partners

LNPEP Antigen Profile

Protein Summary

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with LNPEP

  • leucyl/cystinyl aminopeptidase (LNPEP) antibody
  • leucyl/cystinyl aminopeptidase (lnpep) antibody
  • leucyl/cystinyl aminopeptidase (Lnpep) antibody
  • 2010309L07Rik antibody
  • 4732490P18Rik antibody
  • CAP antibody
  • fb73h12 antibody
  • gp160 antibody
  • IRAP antibody
  • LNPEP antibody
  • P-LAP antibody
  • PLAP antibody
  • Vp165 antibody
  • wu:fb73h12 antibody
  • zgc:66103 antibody

Protein level used designations for LNPEP

leucyl/cystinyl aminopeptidase , leucyl-cystinyl aminopeptidase-like , leucyl-cystinyl aminopeptidase , OTase , cystinyl aminopeptidase , oxytocinase , GP160 , aminopeptidase Vp165 , angiotensin IV receptor , insulin-regulated membrane aminopeptidase IRAP , insulin-responsive aminopeptidase , placental leucine aminopeptidase , vesicle protein of 165 kDa , AT (4) receptor , insulin-regulated aminopeptidase , insulin-regulated membrane aminopeptidase , otase , vasopressinase , AT4 receptor

461960 Pan troglodytes
495293 Xenopus laevis
703949 Macaca mulatta
100015080 Monodelphis domestica
100073222 Equus caballus
100081694 Ornithorhynchus anatinus
100216271 Xenopus (Silurana) tropicalis
100391174 Callithrix jacchus
100473699 Ailuropoda melanoleuca
322814 Danio rerio
100565555 Anolis carolinensis
100603383 Nomascus leucogenys
240028 Mus musculus
171105 Rattus norvegicus
4012 Homo sapiens
521633 Bos taurus
488896 Canis lupus familiaris
427279 Gallus gallus
100718730 Cavia porcellus
100125826 Sus scrofa
100353022 Oryctolagus cuniculus
641307 Ovis aries
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