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Leucyl/cystinyl Aminopeptidase Proteins (LNPEP)

LNPEP encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. Additionally we are shipping LNPEP Antibodies (43) and LNPEP Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LNPEP 240028 Q8C129
Rat LNPEP LNPEP 171105 P97629
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Top LNPEP Proteins at

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

LNPEP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Human , , ,
, ,

More Proteins for Leucyl/cystinyl Aminopeptidase (LNPEP) Interaction Partners

Mouse (Murine) Leucyl/cystinyl Aminopeptidase (LNPEP) interaction partners

  1. IRAP (show IL1RN Proteins) is more highly expressed in pro-inflammatory M1-activated macrophages.

  2. IRAP (show IL1RN Proteins) deficiency may lead to suppression of PAI-1 (show SERPINE1 Proteins) expression in adipocytes and upregulation of UCP-1 (show UCP1 Proteins)-mediated thermogenesis in brown adipose tissue and increased energy expenditure to prevent the development of obesity.

  3. The current study demonstrates that deletion of the IRAP (show IL1RN Proteins) gene protects the brain from ischemic damage

  4. IRAP (show IL1RN Proteins)-deficient mice are less sensitive to the development of acute pentylenetetrazol-induced seizures, demonstrating that IRAP (show IL1RN Proteins) may be involved in generalized seizure generation.

  5. requirement of IRAP (show IL1RN Proteins) in cross-presentation extends to steady-state conventional dendritic cells (cDCs);data suggest increased recruitment of an IRAP (show IL1RN Proteins)(+)/Rab14 (show RAB14 Proteins)(+) compartment to Ag-containing vesicles contributes to cross-presentation efficacy of CD8 (show CD8A Proteins)(+)cDCs

  6. These findings suggest that the IRAP (show IL1RN Proteins) binding protein, vimentin (show VIM Proteins), plays an important role in retention of GLUT4 (show SLC2A4 Proteins) storage vesicles.

  7. IRAP (show IL1RN Proteins) functions in GLUT4 (show SLC2A4 Proteins) sorting from endosomes to GLUT4 (show SLC2A4 Proteins)-specialized compartments.

  8. study shows the high-affinity binding site for angiotensin IV is absent in IRAP (show IL1RN Proteins) knockout mice brain sections in parallel with loss of IRAP (show IL1RN Proteins) immunostaining, providing irrefutable proof that IRAP (show IL1RN Proteins) is the specific high-affinity binding site for AT(4) ligands

  9. Data suggest that the physiological significance of circulating insulin-regulated aminopeptidase during human pregnancy cannot be addressed by investigations on mice.

  10. Initial characterization of knockout mice in which IRAP/P-LAP was deleted revealed that GLUT4 protein levels were dramatically decreased in all fat and muscle tissues.

Human Leucyl/cystinyl Aminopeptidase (LNPEP) interaction partners

  1. The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP (show IL1RN Proteins) were detected in the jejunal mucosa.

  2. Determined is the crystal structure of human IRAP (show IL1RN Proteins) revealing a closed, four domain arrangement with a large, mostly buried cavity abutting the active site.

  3. We identified the missense variant rs2303138 (p.Ala763Thr) within the LNPEP gene associated with psoriasis.

  4. Activities of aminopeptidases N and B and insulin-regulated aminopeptidase could be useful non-invasive biomarkers of Alzheimer's disease from the earliest stages.

  5. An association between maternal common polymorphisms in LNPEP and susceptibility to preterm birth was observed.

  6. The genetic variation in LNPEP (vasopressinase) is associated with 28-day mortality in septic shock and is associated with biologic effects on vasopressin (show AVP Proteins) clearance and serum sodium regulation

  7. investigation of domain structure of IRAP (show IL1RN Proteins); catalytic domains; inhibitor-binding domains; zinc binding sites

  8. Although PLAP (show ALP Proteins) has the necessary enzymatic properties to participate in generating or destroying major histocompatibility class I-presented peptides, its trimming behavior during antigen processing is distinct from that of ERAP1 (show ERAP1 Proteins).

  9. The probable involvement of P-LAP in trophoblast invasion and development of preeclampsia.

  10. Identification of a tankyrase-binding motif in this protein

Cow (Bovine) Leucyl/cystinyl Aminopeptidase (LNPEP) interaction partners

LNPEP Protein Profile

Protein Summary

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with LNPEP

  • leucyl/cystinyl aminopeptidase (LNPEP)
  • leucyl/cystinyl aminopeptidase (lnpep)
  • leucyl/cystinyl aminopeptidase (Lnpep)
  • 2010309L07Rik protein
  • 4732490P18Rik protein
  • CAP protein
  • fb73h12 protein
  • gp160 protein
  • IRAP protein
  • LNPEP protein
  • P-LAP protein
  • PLAP protein
  • Vp165 protein
  • wu:fb73h12 protein
  • zgc:66103 protein

Protein level used designations for LNPEP

leucyl/cystinyl aminopeptidase , leucyl-cystinyl aminopeptidase-like , leucyl-cystinyl aminopeptidase , OTase , cystinyl aminopeptidase , oxytocinase , GP160 , aminopeptidase Vp165 , angiotensin IV receptor , insulin-regulated membrane aminopeptidase IRAP , insulin-responsive aminopeptidase , placental leucine aminopeptidase , vesicle protein of 165 kDa , AT (4) receptor , insulin-regulated aminopeptidase , insulin-regulated membrane aminopeptidase , otase , vasopressinase , AT4 receptor

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100081694 Ornithorhynchus anatinus
100216271 Xenopus (Silurana) tropicalis
100391174 Callithrix jacchus
100473699 Ailuropoda melanoleuca
322814 Danio rerio
100565555 Anolis carolinensis
100603383 Nomascus leucogenys
240028 Mus musculus
171105 Rattus norvegicus
4012 Homo sapiens
521633 Bos taurus
488896 Canis lupus familiaris
427279 Gallus gallus
100718730 Cavia porcellus
100125826 Sus scrofa
100353022 Oryctolagus cuniculus
641307 Ovis aries
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