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LILRB2 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. Additionally we are shipping LILRB2 Proteins (14) and LILRB2 Kits (2) and many more products for this protein.
Showing 10 out of 30 products:
Human Monoclonal LILRB2 Primary Antibody for FACS, IP - ABIN2663608
Colonna, Samaridis, Cella, Angman, Allen, OCallaghan, Dunbar, Ogg, Cerundolo, Rolink: Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. in Journal of immunology (Baltimore, Md. : 1950) 1998
Show all 5 references for ABIN2663608
Human Monoclonal LILRB2 Primary Antibody for FACS, IP - ABIN2656782
Lichterfeld, Kavanagh, Williams, Moza, Mui, Miura, Sivamurthy, Allgaier, Pereyra, Trocha, Feeney, Gandhi, Rosenberg, Altfeld, Allen, Allen, Walker, Sundberg, Yu: A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells. in The Journal of experimental medicine 2007
Show all 4 references for ABIN2656782
Human Monoclonal LILRB2 Primary Antibody for WB - ABIN395008
Zhang, Yu, Li, Liu, Li, Lin, Gao, Wang, Gao, Sun: ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer. in FEBS letters 2015
Data indicate Ig-like transcript 4 (ILT4) as a cellular receptor for complement split products (CSPs) complement component 4d (C4d).
signaling involving ANGPTL2 (show ANGPTL2 Antibodies) and LILRB2 is important for lung cancer development
Findings suggest that ILT4 drives NSCLC development in part on activation of ERK (show EPHB2 Antibodies) signaling which in turn upregulates VEGF-C (show VEGFC Antibodies).
Data show that the leukocyte antigen (show HLADRB4 Antibodies) G HLA-G (show HLAG Antibodies) alpha1-alpha3 structure, which constitutes the extracellular part of HLA-G2 and HLA-G6, binds the immunologic receptor LILRB2 but not LILRB1 (show LILRB1 Antibodies).
Data show that immunoglobulin-like transcript 4 (ILT4) increases the expression of the co-inhibitory molecule B7-H3 (show CD276 Antibodies) through PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signalling.
involvement of ILT3 (show LILRB4 Antibodies) and ILT4 in the modulation of immune responsiveness in multiple sclerosis by both interferon (show IFNA Antibodies) and vitamin D
A novel motif in the first and fourth Ig domains of LILRB2 was identified that is necessary for the receptor to be bound and activated by Angptl2 (show ANGPTL2 Antibodies).
PIRB (show LILRB3 Antibodies) and LILRB2 were expressed in mouse and human platelets, respectively.
ILT4 was found to be highly expressed in primary human ductal and lobular breast cancer cells, and its expression was significantly correlated with more IL-10 (show IL10 Antibodies) expression.
we propose an impact of LILRB2 on HIV-1 disease outcomes through altered regulation of DCs by LILRB2-HLA engagement
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
, leukocyte immunoglobulin-like receptor subfamily B member 2-like
, CD85 antigen-like family member D
, Ig-like transcript 4
, leukocyte immunoglobulin-like receptor subfamily B member 2
, monocyte/macrophage immunoglobulin-like receptor 10