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LILRB4 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. Additionally we are shipping LILRB4 Kits (15) and and many more products for this protein.
Showing 10 out of 67 products:
Mouse (Murine) Monoclonal LILRB4 Primary Antibody for FACS - ABIN2664845
Castells, Wu, Arm, Austen, Katz: Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. in The Journal of biological chemistry 1994
Show all 5 references for ABIN2664845
Mouse (Murine) Monoclonal LILRB4 Primary Antibody for FACS - ABIN2662685
Jiang, Barclay: New assay to detect low-affinity interactions and characterization of leukocyte receptors for collagen including leukocyte-associated Ig-like receptor-1 (LAIR-1). in European journal of immunology 2009
Show all 5 references for ABIN2662685
Mouse (Murine) Monoclonal LILRB4 Primary Antibody for FACS, IF - ABIN2657189
Kuroiwa, Yamashita, Inui, Yuasa, Ono, Nagabukuro, Matsuda, Takai: Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene. in The Journal of biological chemistry 1998
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Human Polyclonal LILRB4 Primary Antibody for EIA, WB - ABIN951418
Lu, Rentero, Raftery, Borges, Bryant, Tedla: Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases. in The Journal of biological chemistry 2009
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Human Monoclonal LILRB4 Primary Antibody for ICFC - ABIN2664846
Penna, Roncari, Amuchastegui, Daniel, Berti, Colonna, Adorini: Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3. in Blood 2005
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Human Monoclonal LILRB4 Primary Antibody for FACS - ABIN2659327
Cella, Döhring, Samaridis, Dessing, Brockhaus, Lanzavecchia, Colonna: A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. in The Journal of experimental medicine 1997
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Human Polyclonal LILRB4 Primary Antibody for IF, ELISA - ABIN1535003
Liu, Kim, Nwankwo, Ashworth, Arm: Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. in Immunogenetics 2000
Identification of ILT4 (show LILRB2 Antibodies) as a cellular receptor for CSP (show DNAJC5 Antibodies) C4d
involvement of ILT3 and ILT4 (show LILRB2 Antibodies) in the modulation of immune responsiveness in multiple sclerosis by both interferon (show IFNA Antibodies) and vitamin D
Cyclosporine up-regulated the expression of ILT3 and ILT4 (show LILRB2 Antibodies) on natural killer cells, which influenced their cytotoxicity against tumor cells.
Crystal structure of leukocyte Ig-like receptor (show LILRA6 Antibodies) LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.
Data show that LILRB4 is a potent inhibitor of monocyte activation via FcgammaRI (show FCGR1A Antibodies).
report that ILT2 (show LILRB1 Antibodies) receptor, ILT3 receptor, ILT4 (show LILRB2 Antibodies) receptor, and KIR2DL4 (show KIR2DL4 Antibodies) receptor expression is up-regulated by HLA-G (show HLAG Antibodies) histocompatibility antigen in antigen-presenting cells, natural killer cells, and T cells
ILT3 precursor RNA is expressed and retained in nuclei of resting endothelial cells.
Our findings indicate that expression of ILT3 and ILT4 (show LILRB2 Antibodies) on CLL B cells represents a phenotypic abnormality that may play a role in tolerization of tumor-specific T cells.
The inhibitory effect of serum and membrane ILT3 in a humanized SCID (show PRKDC Antibodies) mouse model describes an immune-escape mechanism that could contribute to impaired T cell responses in patients with cancer.
Both membrane and soluble ILT3 are proteins with potent immunosuppressive activity which are of importance for treatment of rejection, autoimmunity and cancer.
Results suggest that plasma cell development from memory and marginal zone B cells, as well as subsequent antibody production, are suppressed via glycoprotein 49B (gp49B).
LILRB4 can downregulate the development of pathologic allergic inflammation.
receptor attenuates the number of these mature DCs and attendant IL-4 (show IL4 Antibodies)-producing lymphocytes in the lymph nodes, and accordingly, the ability of DCs to elicit pathologic Th2 pulmonary inflammation
Gp49B1 is a unique inhibitory receptor that is induced in multiple lineages of innate and adaptive immune cells during an infection and controls their IFN-gamma (show IFNG Antibodies), but not cytotoxic responses.
Expression of gp49B was detected on peripheral eosinophils of control mice and on eosinophils from lungs of mice treated with RW, suggesting a role for gp49B on eosinophils in dampening allergic inflammatory responses.
study reports that gp49B, is expressed on dendritic cells and downregulates cellular activity to prevent the excessive activation of T cells in vitro and in vivo
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
, CD85 antigen-like family member K
, immunoglobulin-like transcript 3
, leukocyte immunoglobulin-like receptor 5
, leukocyte immunoglobulin-like receptor subfamily B member 4
, monocyte inhibitory receptor HM18
, glycoprotein 49 B
, mast cell surface glycoprotein Gp49B