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LILRA4 encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). Additionally we are shipping Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 4 Antibodies (45) and many more products for this protein.
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Crosslinked ILT7 favours the differentiation of immature plasmacytoid dendritic cells into antigen-presenting cells rather than IPC.
ILT7 may exert its immunomodulatory activity only on immature circulating plasmacytoid dendritic cells (pDCs), providing a basic homeostatic mechanism rather than negative feedback control on activated pDCs.
Intracellular expression of the TCL1 (show TCL1A Proteins) as well as membrane and intracellular expression of ILT7 in plasmacytoid dendritic cell leukemia (pDCL (show PDCL Proteins)) samples and 61 non-pDC (show PNKD Proteins) acute leukemia samples, were tested.
the expression of immunoglobulin-like transcript 7, in plasmacytoid dendritic cells
ILT7 protein associates with the signal adapter protein (show TOLLIP Proteins) Fc epsilonRI gamma to form a receptor complex in dendritic cells.
key regulator of human pDC (show PNKD Proteins) function and interferon (show IFNA Proteins) type I production.
Data show that BST2 (show BST2 Proteins) directly binds to purified ILT7, initiates signaling via the ILT7-FcepsilonRIgamma complex, and regulates TLR7 (show TLR7 Proteins)/9 responses in plasmacytoid dendritic cells.
This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte receptor gene cluster (LRC) at chromosomal region 19q13.4.
leukocyte immunoglobulin-like receptor subfamily A member 4
, immunoglobulin-like transcript 7
, CD85 antigen-like family member G
, leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4