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The protein encoded by LST1 is a membrane protein that can inhibit the proliferation of lymphocytes. Additionally we are shipping LST1 Proteins (4) and LST1 Kits (2) and many more products for this protein.
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Human Monoclonal LST1 Primary Antibody for ICC, IP - ABIN343705
Mulcahy, ORourke, Adams, Molloy, OGara: LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection. in Immunogenetics 2006
Show all 4 references for ABIN343705
Increased expression of LST1 (show NFKBIL1 Antibodies) in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis.
Data indicate that the MHC (show HLAE Antibodies) class III gene LST1 (show NFKBIL1 Antibodies) 5' untranslated regions (5'-UTR (show UTS2R Antibodies)) contains several upstream open reading frames (uORFs).
Psoriasis was associated with promoter variant, rs9267502 of LST1 (show NFKBIL1 Antibodies).Promoter activity was examined and it was larger than that of the other genetic variants, most probably due to changes in binding affinity to transcription factors.
This is the first report demonstrating regulated LST1 (show NFKBIL1 Antibodies) expression in human intestinal epithelial and microvascular endothelial cells and in inflamed colonic tissue from IBD patients.
LST1 is expressed specifically in leukocytes of the myeloid lineage, where it localizes to the tetraspanin-enriched microdomains andit binds SHP-1 and SHP-2 phosphatases.
Study found association between extended LTA (show LTA Antibodies), TNF (show TNF Antibodies), LST1 (show NFKBIL1 Antibodies) and HLA gene haplotypes and rubella vaccine-induced immunity.
Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 (show NCR3 Antibodies) receptor by activated NK cells.
Expression of this receptor, inhibited by TGF-beta1 (show TGFB1 Antibodies), affects NK-mediated killing of dendritic cells
The expression of LST1 (show NFKBIL1 Antibodies), specifically splice variants encoding soluble isoforms and NCR3 (show NCR3 Antibodies), was increased in rheumatoid-arthritis-affected blood and synovium and was associated with more severe inflammation in the synovium.
LST1 (show NFKBIL1 Antibodies) protein expression in human cell lines was found to be tightly regulated, allowing the expression of transmembrane isoforms but suppressing soluble isoforms
The absence of Lst1 leads to a slightly more susceptible phenotype. However, deletion of Lst1 in DBA (show RPS19 Antibodies)/2 J mice alone does not explain the high susceptibility of this strain to PR8M influenza infections.
The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene.
leukocyte-specific transcript 1 protein
, lymphocyte antigen 117
, leucocyte specific transcript 1