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The protein encoded by LTK is a member of the ros/insulin receptor family of tyrosine kinases.
In hippocampus, Ltk and Alk (anaplastic lymphoma kinase) are expressed throughout dentate gyrus, CA1, and CA3. Data suggest genetic interactions between Ltk and Alk in neurogenesis and behavioral measures (i.e., activity, anxiety, spatial memory).
polymorphic LTKs cause up-regulation of the PI3K pathway and possibly form one genetic component of susceptibility to abnormal proliferation of self-reactive B cells in systemic lupus erythematosus
LAR (show PTPRF ELISA Kits) regulates Fyn (show FYN ELISA Kits)/JAK2 (show JAK2 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) and Fyn (show FYN ELISA Kits)/p38 MAPK (show MAPK14 ELISA Kits) pathways involved in ROS (show ROS1 ELISA Kits)-induced apoptosis
Translation initiates from a non-AUG codon (CUG) in some Ltk transcript variants.
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons.
leukocyte receptor tyrosine kinase
, leukocyte tyrosine kinase receptor