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Leukocyte-Associated Immunoglobulin-Like Receptor 1 Proteins (LAIR1)

The protein encoded by LAIR1 is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Additionally we are shipping LAIR1 Antibodies (160) and LAIR1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LAIR1 52855 Q8BG84
LAIR1 3903 Q6GTX8
Rat LAIR1 LAIR1 574531 P0C1X9
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Top LAIR1 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$545.60
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Cells Human His tag   50 μg Log in to see 5 Days
$269.50
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

LAIR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
, ,
Human , , , , ,
, ,

Top referenced LAIR1 Proteins

  1. Human LAIR1 Protein expressed in Escherichia coli (E. coli) - ABIN666805 : Sathish, Johnson, Fuller, LeRoy, Meyaard, Sims, Matthews: Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells. in Journal of immunology (Baltimore, Md. : 1950) 2001 (PubMed)
    Show all 2 references for ABIN666805

More Proteins for Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) Interaction Partners

Mouse (Murine) Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) interaction partners

  1. The LAIR1-SHP-1 (show PTPN6 Proteins)-CAMK1 (show CAMK1 Proteins)-CREB (show CREB1 Proteins) pathway sustains the survival and self-renewal of AML (show RUNX1 Proteins) stem cells.

  2. LAIR-1-deficient mice are healthy and fertile with normal longevity, showing increased numbers of splenic B, regulatory T, and dendritic cells.

  3. tumor-expressed collagens can bind and trigger immune inhibitory signaling via LAIR-1, suggesting that collagens indeed may affect tumor immune evasion.

  4. Mouse Lair-1 cytoplasmic tail can become phosphorylated, thereby recruiting SH2-containing tyrosine phosphatase-2 (SHP-2 (show PTPN11 Proteins)). Unlike human LAIR-1, SHP-1 (show PTPN6 Proteins) is not recruited to the mouse Lair-1 cytoplasmic tail.

  5. analysis of leukocyte Ig-like receptor (show LILRA6 Proteins) signaling and crystal structure of disulfide-linked HLA-G (show HLAG Proteins) dimer

  6. findings show that mLAIR-1 interacted with high affinity with a wide range of collagen molecules; mLAIR-1 cross-linking with its ligands inhibits CD3 (show CD3E Proteins)-induced T cell stimulation in vitro

Human Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) interaction partners

  1. We suggest that LAIR1 and LAIR2 (show LAIR2 Proteins) genetic variants are associated with regulation of gene expression and variable pemphigus foliaceus (show DSG1 Proteins) susceptibility, and show indirect association of LAIR2 (show LAIR2 Proteins) differential mRNA expression with pemphigus foliaceus (show DSG1 Proteins) pathogenesis.

  2. A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens;findings illustrate, with a biologically relevant example, a novel mechanism of antibody diversification by interchromosomal DNA transposition

  3. C1q-mediated repression of human monocytes is regulated by LAIR-1

  4. The LAIR1-SHP-1 (show PTPN6 Proteins)-CAMK1 (show CAMK1 Proteins)-CREB (show CREB1 Proteins) pathway sustains the survival and self-renewal of AML (show RUNX1 Proteins) stem cells.

  5. These data suggest that LAIR-1 has a relevant impact on EOC progression and may be helpful for a better understanding of molecular pathogenesis of cancer.

  6. LAIR1 expression is a reliable and inexpensive marker capable of independently predicting time to first treatment in newly diagnosed unselected patients with chronic lymphocytic leukemia.

  7. The expression of LAIR -1 on pDCs of juvenile systemic lupus erythematosus patients was significantly lower than that of control patients.

  8. a novel pathway for the immunomodulatory functions of SP-D (show SFTPD Proteins) mediated via binding of its collagenous domains to LAIR-1.

  9. LAIR-1 may play an important role in immune imbalance in children with immune thrombocytopenia.

  10. Studies indicate that Megakaryocyte maturation is accompanied by up-regulation of glycoprotein VI and down-regulation of leukocyte-associated immunoglobulin-like receptor-1.

LAIR1 Protein Profile

Protein Summary

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Gene names and symbols associated with LAIR1

  • leukocyte-associated Ig-like receptor 1 (Lair1)
  • leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)
  • leukocyte-associated immunoglobulin-like receptor 1 (Lair1)
  • 5133400O11Rik protein
  • BB115266 protein
  • CD305 protein
  • D7Bwg0421e protein
  • LAIR-1 protein
  • mLair-1 protein

Protein level used designations for LAIR1

leukocyte-associated immunoglobulin-like receptor 1 , mLAIR1 , hLAIR1 , leukocyte-associated Ig-like receptor 1 , LAIR-1 , leukocyte-associated Ig-like receptor-1 , rLAIR1

GENE ID SPECIES
52855 Mus musculus
3903 Homo sapiens
574531 Rattus norvegicus
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