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The protein encoded by LAIR1 is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Additionally we are shipping LAIR1 Antibodies (229) and LAIR1 Kits (15) and many more products for this protein.
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LAIR-1 in megakaryocytes leads to increased Src (show SRC Proteins) family kinase activity and downstream signaling in response to collagen that is transmitted to platelets, rendering them hyper-reactive specifically to agonists that signal through Syk (show SYK Proteins) tyrosine kinases.
The LAIR1-SHP-1 (show PTPN6 Proteins)-CAMK1 (show CAMK1 Proteins)-CREB (show CREB1 Proteins) pathway sustains the survival and self-renewal of AML (show RUNX1 Proteins) stem cells.
LAIR-1-deficient mice are healthy and fertile with normal longevity, showing increased numbers of splenic B, regulatory T, and dendritic cells.
tumor-expressed collagens can bind and trigger immune inhibitory signaling via LAIR-1, suggesting that collagens indeed may affect tumor immune evasion.
Mouse Lair-1 cytoplasmic tail can become phosphorylated, thereby recruiting SH2-containing tyrosine phosphatase-2 (SHP-2 (show PTPN11 Proteins)). Unlike human LAIR-1, SHP-1 (show PTPN6 Proteins) is not recruited to the mouse Lair-1 cytoplasmic tail.
analysis of leukocyte Ig-like receptor (show LILRA6 Proteins) signaling and crystal structure of disulfide-linked HLA-G (show HLAG Proteins) dimer
findings show that mLAIR-1 interacted with high affinity with a wide range of collagen molecules; mLAIR-1 cross-linking with its ligands inhibits CD3 (show CD3E Proteins)-induced T cell stimulation in vitro
We suggest that LAIR1 and LAIR2 (show LAIR2 Proteins) genetic variants are associated with regulation of gene expression and variable pemphigus foliaceus (show DSG1 Proteins) susceptibility, and show indirect association of LAIR2 (show LAIR2 Proteins) differential mRNA expression with pemphigus foliaceus (show DSG1 Proteins) pathogenesis.
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens;findings illustrate, with a biologically relevant example, a novel mechanism of antibody diversification by interchromosomal DNA transposition
C1q-mediated repression of human monocytes is regulated by LAIR-1
These data suggest that LAIR-1 has a relevant impact on EOC progression and may be helpful for a better understanding of molecular pathogenesis of cancer.
LAIR1 expression is a reliable and inexpensive marker capable of independently predicting time to first treatment in newly diagnosed unselected patients with chronic lymphocytic leukemia.
The expression of LAIR -1 on pDCs of juvenile systemic lupus erythematosus patients was significantly lower than that of control patients.
a novel pathway for the immunomodulatory functions of SP-D (show SFTPD Proteins) mediated via binding of its collagenous domains to LAIR-1.
LAIR-1 may play an important role in immune imbalance in children with immune thrombocytopenia.
Studies indicate that Megakaryocyte maturation is accompanied by up-regulation of glycoprotein VI and down-regulation of leukocyte-associated immunoglobulin-like receptor-1.
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.
leukocyte-associated immunoglobulin-like receptor 1
, leukocyte-associated Ig-like receptor 1
, leukocyte-associated Ig-like receptor-1