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Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Additionally we are shipping Leukotriene A4 Hydrolase Antibodies (90) and Leukotriene A4 Hydrolase Kits (19) and many more products for this protein.
Showing 10 out of 13 products:
Human LTA4H Protein expressed in HEK-293 Cells - ABIN2181484
Odlander, Claesson, Bergman, Rådmark, Jörnvall, Haeggström: Leukotriene A4 hydrolase in the human B-lymphocytic cell line Raji: indications of catalytically divergent forms of the enzyme. in Archives of biochemistry and biophysics 1991
Show all 7 references for ABIN2181484
Mouse (Murine) LTA4H Protein expressed in Baculovirus infected Insect Cells - ABIN2007591
Mancini, Evans: Cloning and characterization of the human leukotriene A4 hydrolase gene. in European journal of biochemistry / FEBS 1995
Show all 4 references for ABIN2007591
Human LTA4H Protein expressed in Baculovirus infected Insect Cells - ABIN2002493
Orning, Gierse, Fitzpatrick: The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity. in The Journal of biological chemistry 1994
Show all 4 references for ABIN2002493
lta4h mutations confer hypersusceptibility to mycobacterial infection by redirecting eicosanoid substrates to anti-inflammatory lipoxins.
Mutating F375 in xlLTA4H to tyrosine abolishes the formation of the LTB4 (show PTGR1 Proteins) isomeric product Delta(6)-trans-Delta(8)-cis (show CISH Proteins)-LTB4 (show PTGR1 Proteins).
LTA4H promoter region SNP was associated with susceptibility to bacteriologically confirmed bacterial meningitis but did not influence clinical presentation, disease severity or survival following dexamethasone treatment.
Report no association between LTA4H SNPs and atherosclerotic plaque phenotypes.
The best proteinogenic amino acid recognized by LTA4H is arginine.
The results of our study failed to confirm whether the selected variants in LTA4H gene within the LT metabolism pathway contribute to platelet reactivity in a diabetic population treated with ASA (show ARSA Proteins).
The LTA4H A-9188>G polymorphism has a strong association with severe asthma in children.
Data indicate that 13S,14S-epoxy-docosahexaenoic acid (DHA) inhibits leukotriene B4 (LTB4 (show PTGR1 Proteins)) biosynthesis by leukotriene A4 hydrolase (LTA4H).
genetic association studies in population of Han Chinese in Eastern China: Using a recessive genetic model, an SNP in LTA4H (rs6538697) is associated with increased risk of ischemic stroke.
Structural origins for the loss of catalytic activities of bifunctional human LTA4H revealed through molecular dynamics simulations.
It was found modest association with LTA4H rs1978331C (intron 11) with increased FEV1 (p = 0.029) and with increased FEV1/FVC ratio (p = 0.020).
common polymorphisms in the LTA4H gene do not play any major role in susceptibility to clinical pulmonary tuberculosis
There is a critical role for the secondary anti-inflammatory activity of LTA4H in acute pulmonary infection.
CS exposure promotes the development of CS-induced emphysema by suppressing the enzymatic activities of the LTA4H aminopeptidase in lung tissues and accumulating PGP and neutrophils in the airspaces.
in acute neutrophil-driven lung inflammation, PGP was degraded by LTA(4)H which facilitated resolution of inflammation; cigarette smoke, a major risk factor for COPD,inhibited LTA(4)H aminopeptidase activity leading to accumulation of PGP and neutrophils
5-lipoxygenase (show ALOX5 Proteins) and leukotriene A4 hydrolase expression in atherosclerotic lesions correlates with symptoms of plaque instability
In the mouse nervous system ,Immunoreactivity for leukotriene A4 hydrolase showed widespread distribution with preference to the sensory-associated structures.
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
leukotriene A4 hydrolase
, leukotriene A-4 hydrolase
, Leukotriene A4 hydrolase
, leukotriene A-4 hydrolase-like
, LTA-4 hydrolase
, aminopeptidase T
, leukotriene A(4) hydrolase
, LTA4 hydrodase
, LTA4 hydrolase