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Leukotriene A4 Hydrolase Proteins (LTA4H)

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Additionally we are shipping Leukotriene A4 Hydrolase Antibodies (90) and Leukotriene A4 Hydrolase Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LTA4H 4048 P09960
LTA4H 16993 P24527
LTA4H 299732  
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Top Leukotriene A4 Hydrolase Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 20 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Baculovirus infected Insect Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Baculovirus infected Insect Cells Mouse His tag 50 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human His tag   0.02 mg Log in to see 2 to 3 Days
$584.38
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,756.50
Details
HOST_HEK-293 Cells Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details

LTA4H Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
,
Mouse (Murine) ,

Rat (Rattus)

Top referenced Leukotriene A4 Hydrolase Proteins

  1. Human LTA4H Protein expressed in HEK-293 Cells - ABIN2181484 : Odlander, Claesson, Bergman, Rådmark, Jörnvall, Haeggström: Leukotriene A4 hydrolase in the human B-lymphocytic cell line Raji: indications of catalytically divergent forms of the enzyme. in Archives of biochemistry and biophysics 1991 (PubMed)
    Show all 7 references for ABIN2181484

  2. Mouse (Murine) LTA4H Protein expressed in Baculovirus infected Insect Cells - ABIN2007591 : Mancini, Evans: Cloning and characterization of the human leukotriene A4 hydrolase gene. in European journal of biochemistry / FEBS 1995 (PubMed)
    Show all 4 references for ABIN2007591

  3. Human LTA4H Protein expressed in Baculovirus infected Insect Cells - ABIN2002493 : Orning, Gierse, Fitzpatrick: The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity. in The Journal of biological chemistry 1994 (PubMed)
    Show all 4 references for ABIN2002493

More Proteins for Leukotriene A4 Hydrolase (LTA4H) Interaction Partners

Zebrafish Leukotriene A4 Hydrolase (LTA4H) interaction partners

  1. lta4h mutations confer hypersusceptibility to mycobacterial infection by redirecting eicosanoid substrates to anti-inflammatory lipoxins.

Xenopus laevis Leukotriene A4 Hydrolase (LTA4H) interaction partners

  1. Mutating F375 in xlLTA4H to tyrosine abolishes the formation of the LTB4 (show PTGR1 Proteins) isomeric product Delta(6)-trans-Delta(8)-cis (show CISH Proteins)-LTB4 (show PTGR1 Proteins).

Human Leukotriene A4 Hydrolase (LTA4H) interaction partners

  1. LTA4H promoter region SNP was associated with susceptibility to bacteriologically confirmed bacterial meningitis but did not influence clinical presentation, disease severity or survival following dexamethasone treatment.

  2. Report no association between LTA4H SNPs and atherosclerotic plaque phenotypes.

  3. The best proteinogenic amino acid recognized by LTA4H is arginine.

  4. The results of our study failed to confirm whether the selected variants in LTA4H gene within the LT metabolism pathway contribute to platelet reactivity in a diabetic population treated with ASA (show ARSA Proteins).

  5. The LTA4H A-9188>G polymorphism has a strong association with severe asthma in children.

  6. Data indicate that 13S,14S-epoxy-docosahexaenoic acid (DHA) inhibits leukotriene B4 (LTB4 (show PTGR1 Proteins)) biosynthesis by leukotriene A4 hydrolase (LTA4H).

  7. genetic association studies in population of Han Chinese in Eastern China: Using a recessive genetic model, an SNP in LTA4H (rs6538697) is associated with increased risk of ischemic stroke.

  8. Structural origins for the loss of catalytic activities of bifunctional human LTA4H revealed through molecular dynamics simulations.

  9. It was found modest association with LTA4H rs1978331C (intron 11) with increased FEV1 (p = 0.029) and with increased FEV1/FVC ratio (p = 0.020).

  10. common polymorphisms in the LTA4H gene do not play any major role in susceptibility to clinical pulmonary tuberculosis

Mouse (Murine) Leukotriene A4 Hydrolase (LTA4H) interaction partners

  1. There is a critical role for the secondary anti-inflammatory activity of LTA4H in acute pulmonary infection.

  2. CS exposure promotes the development of CS-induced emphysema by suppressing the enzymatic activities of the LTA4H aminopeptidase in lung tissues and accumulating PGP and neutrophils in the airspaces.

  3. in acute neutrophil-driven lung inflammation, PGP was degraded by LTA(4)H which facilitated resolution of inflammation; cigarette smoke, a major risk factor for COPD,inhibited LTA(4)H aminopeptidase activity leading to accumulation of PGP and neutrophils

  4. 5-lipoxygenase (show ALOX5 Proteins) and leukotriene A4 hydrolase expression in atherosclerotic lesions correlates with symptoms of plaque instability

  5. In the mouse nervous system ,Immunoreactivity for leukotriene A4 hydrolase showed widespread distribution with preference to the sensory-associated structures.

Leukotriene A4 Hydrolase (LTA4H) Protein Profile

Protein Summary

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

Gene names and symbols associated with LTA4H

  • leukotriene A4 hydrolase (LTA4H)
  • leukotriene A4 hydrolase (lta4h)
  • leukotriene A4 hydrolase (LOC732953)
  • leukotriene A4 hydrolase (Shew185_1367)
  • leukotriene A4 hydrolase (Sbal195_1406)
  • leukotriene A4 hydrolase (XfasM23_0741)
  • Leukotriene A4 hydrolase (Sbal223_2977)
  • leukotriene A4 hydrolase (lkhA)
  • leukotriene A4 hydrolase (Lta4h)
  • AmpT protein
  • DDBDRAFT_0191291 protein
  • DDBDRAFT_0216768 protein
  • DDB_0191291 protein
  • DDB_0216768 protein
  • LOC732953 protein
  • lta4h protein
  • MGC69197 protein
  • MGC78867 protein
  • zgc:85809 protein

Protein level used designations for LTA4H

leukotriene A4 hydrolase , leukotriene A-4 hydrolase , Leukotriene A4 hydrolase , leukotriene A-4 hydrolase-like , LTA-4 hydrolase , aminopeptidase T , leukotriene A(4) hydrolase , LTA4 hydrodase , LTA4 hydrolase

GENE ID SPECIES
713038 Macaca mulatta
100017641 Monodelphis domestica
100052257 Equus caballus
100171657 Pongo abelii
100565831 Anolis carolinensis
100595121 Nomascus leucogenys
406575 Danio rerio
432332 Xenopus laevis
448745 Xenopus (Silurana) tropicalis
452145 Pan troglodytes
732953 Bombyx mori
5370072 Shewanella baltica OS185
5753135 Shewanella baltica OS195
6202962 Xylella fastidiosa M23
7089045 Shewanella baltica OS223
8617739 Dictyostelium discoideum AX4
100413464 Callithrix jacchus
4048 Homo sapiens
482611 Canis lupus familiaris
100154219 Sus scrofa
507130 Bos taurus
16993 Mus musculus
299732 Rattus norvegicus
417918 Gallus gallus
100135571 Cavia porcellus
100357727 Oryctolagus cuniculus
102007852 Chinchilla lanigera
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