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Leupaxin Proteins (LPXN)

The product encoded by LPXN is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Additionally we are shipping Leupaxin Antibodies (45) and Leupaxin Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LPXN 9404 O60711
LPXN 107321 Q99N69
Rat LPXN LPXN 293783  
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Top Leupaxin Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,063.50
Details

LPXN Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Leupaxin (LPXN) Interaction Partners

Human Leupaxin (LPXN) interaction partners

  1. The full-length leupaxin binds to the Pyk2 (show PTK2B Proteins)-focal adhesion targeting domain.

  2. Authors demonstrate that LPXN directly influences cytoskeletal dynamics via interaction with the actin-binding protein (show KPTN Proteins) CaD and regulates CaD phosphorylation by recruiting ERK (show EPHB2 Proteins) to highly dynamic structures within PCa (show FLVCR1 Proteins) cells.

  3. Results show that leupaxin has particular influence on the progression and invasion of breast cancer cells and may therefore represent an interesting candidate protein for diagnosis and therapeutic interventions.

  4. first evidence of dynamic regulation of leupaxin localization and tyrosine phosphorylation by G-Protein Coupled Receptors

  5. leupaxin functions as a paxillin (show PXN Proteins) counterpart that potently suppresses the tyrosine phosphorylation of paxillin (show PXN Proteins) during integrin signaling.

  6. leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex

  7. Leupaxin binding to tyrosine phosphatase PEP suggests that leupaxin may function as a signal-transducing complex with PEP.

  8. These data demonstrate that LPXN forms a signaling complex with Pyk2 (show PTK2B Proteins), c-Src (show SRC Proteins), and PTP-PEST (show PTPN12 Proteins) to regulate migration of prostate cancer cells.

  9. Leupaxin plays an inhibitory role in BCR (show BCR Proteins) signaling and B cell function.

  10. leupaxin could serve as a potential progression marker for a subset of PCa (show FLVCR1 Proteins) and may represent a novel coactivator of the androgen receptor (show AR Proteins)

Mouse (Murine) Leupaxin (LPXN) interaction partners

  1. leupaxin functions as a paxillin (show PXN Proteins) counterpart that potently suppresses the tyrosine phosphorylation of paxillin (show PXN Proteins) during integrin signaling.

  2. leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex

  3. Association of the scaffold protein (show HOMER1 Proteins) LPXN with Src (show SRC Proteins) adds further complexity to the organization of the podosomal signaling complex in osteoclasts.

  4. Leupaxin plays an inhibitory role in BCR (show BCR Proteins) signaling and B cell function.

  5. Leupaxin is enriched in mouse vascular smooth muscle and its expression is dynamically regulated during development.

Leupaxin (LPXN) Protein Profile

Protein Summary

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with Leupaxin Proteins (LPXN)

  • leupaxin (LPXN)
  • si:rp71-15d4.1 (si:rp71-15d4.1)
  • leupaxin (PAAG_03110)
  • leupaxin (PGTG_11441)
  • Leupaxin (lpxn)
  • leupaxin (Lpxn)
  • 4933402K05Rik protein
  • A530083L21Rik protein
  • AV278559 protein
  • LDPL protein
  • MGC140379 protein

Protein level used designations for Leupaxin Proteins (LPXN)

leupaxin , Leupaxin

GENE ID SPECIES
281277 Bos taurus
423129 Gallus gallus
451205 Pan troglodytes
483465 Canis lupus familiaris
513264 Bos taurus
560743 Danio rerio
702033 Macaca mulatta
9097993 Paracoccidioides sp. 'lutzii' Pb01
10527262 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100066577 Equus caballus
100196515 Salmo salar
100394284 Callithrix jacchus
100445873 Pongo abelii
100592030 Nomascus leucogenys
9404 Homo sapiens
107321 Mus musculus
293783 Rattus norvegicus
100008712 Oryctolagus cuniculus
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