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Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway..
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Low LBH level, caused by a rheumatoid arthritis risk allele, is a risk factor for aggressive fibroblast-like synoviocyte behavior.
The expression levels of LBH mRNA in patients with SLE were significantly decreased compared with those in normal controls (P < 0.001). No significant differences were found between LBH mRNA expression levels and SLE disease activity scores, SNP rs7579944 and rs906868.
LBH normally induces NPC (show NPC1 Proteins) cell cycle arrest at the G1/S transition, and LBH can suppress the growth of transplanted NPC (show NPC1 Proteins) tumors in vivo by downregulating LMP1 (show PDLIM7 Proteins)-mediated NF-kappaB (show NFKB1 Proteins) transcriptional activity.
LBH is a candidate gene for synovial pathology in rheumatoid arthritis. It is regulated by growth factors and modulates cell growth in primary fibroblast-like synoviocytes.
results showed that the interaction of LBH and alphaB-crystallin (show CRYAB Proteins) may inhibit synergistically the transcriptional regulation of p53 (show TP53 Proteins) and p21 (show CDKN1A Proteins)
LBH is aberrantly overexpressed in mammary tumors of mouse mammary tumor virus (MMTV)-Wnt1 (show WNT1 Proteins)-transgenic mice and in aggressive basal subtype human breast cancers that display Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) hyperactivation.
LBH is implicated as a candidate gene for congenital heart disease associated with partial trisomy 2p syndrome
These results suggest that hLBH proteins may act as a transcriptional activator in mitogen-activated protein kinase (show MAPK1 Proteins) signaling pathway to mediate cellular functions.
The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage.
during endochondral bone formation, Lbh may negatively regulate vascular invasion and formation of the early ossification center at least in part by interfering with Runx2 and/or VEGF expression
Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway.
, limb bud and heart development homolog
, protein LBH
, cleavage 2 protein
, limb bud and heart-expressed protein