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The protein encoded by LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. Additionally we are shipping LIN28B Antibodies (77) and LIN28B Proteins (7) and many more products for this protein.
Upregulation of let-7a carries the potential to reverse CCL18 (show CCL18 ELISA Kits) induced cell proliferation and migration alteration in breast cancer cells by regulating Lin28 (show LIN28A ELISA Kits) expression.
LIN28B orchestrates oncogenic signaling in neuroblastoma (show ARHGEF16 ELISA Kits).
loss of SIRT6 (show SIRT6 ELISA Kits) results in hyperacetylation of H3K9 and H3K56 at the promoter of the LIN28B gene, creating a more permissive chromatin state and allowing for the Myc (show MYC ELISA Kits) transcription factor to drive its expression
Compared with NCMT samples from the same OSCC patient, the expression of Lin28B was increased in all of the tumor samples. A similar upregulation of Lin28B was also observed in LN metastatic when compared with local tumors.
suggest that molecular subtypes of the LIN-28B/let-7a/IGF-II axis associate with heterogeneous progression
let-7 disruption by LIN28B, MYCN (show MYCN ELISA Kits) sponging, or genetic loss is a unifying mechanism of neuroblastoma (show ARHGEF16 ELISA Kits) development with broad implications for cancer pathogenesis
elevated LIN28B expression as a hallmark of a novel fetal-like subgroup in Juvenile myelomonocytic leukemia.
Lin28B/let-7 pathway is tightly regulated by macroH2A1 (show H2AFY ELISA Kits)
Data show that RNA-binding protein (show PTBP1 ELISA Kits) LIN28B coordinates the expression of the oncogene (show RAB1A ELISA Kits) RAN protein and aurora A kinase (AURKA (show AURKA ELISA Kits)) in neuroblastoma (show ARHGEF16 ELISA Kits).
Data implicate LIN28 (show LIN28A ELISA Kits)/RAS/MAP kinase (show MAPK1 ELISA Kits) as key drivers of tumorigenesis atypical teratoid rhabdoid tumors.
data point toward a complex system of regulation by Lin28a (show LIN28A ELISA Kits), Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner
Lin28B/let-7 axis acts as a critical driver of peripheral nervous system myelination
These results implicate a key role for the LIN28B/let-7 axis in regulating postnatal supporting cell (show PTPRJ ELISA Kits) plasticity.
Upregulation of LIN28B is associated with systemic mastocytosis.
Lin28a (show LIN28A ELISA Kits) and Lin28b have overlapping functions in temporally regulating neural progenitor cell proliferation during early brain development.
VH repertoire of Lin28b-induced BM B1a B cells differs from that of normal B1a, suggesting persisting differences from fetal progenitors.
Our data imply dual repression of Let-7 during oocyte-embryo transition in the mouse model, the selective suppression of Let-7 biogenesis by Lin28 (show LIN28A ELISA Kits) homologs superimposed on previously reported global suppression of miRNA activity.
Data implicate fetal expression of Lin28a (show LIN28A ELISA Kits)/b in the regulation of life-long effects on metabolism and growth.
MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging
intestine targeted expression of LIN28B causes intestinal hypertrophy, crypt expansion, and Paneth cell loss
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.
lin-28 homolog B (C. elegans)
, lin-28 homolog B
, protein lin-28 homolog B