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Lin-28 Homolog B (C. Elegans) (LIN28B) ELISA Kits

The protein encoded by LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. Additionally we are shipping LIN28B Antibodies (73) and LIN28B Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human LIN28B LIN28B 389421 Q6ZN17
Anti-Mouse LIN28B LIN28B 380669 Q45KJ6
Anti-Rat LIN28B LIN28B 689054  
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More ELISA Kits for LIN28B Interaction Partners

Human Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. Compared with NCMT samples from the same OSCC patient, the expression of Lin28B was increased in all of the tumor samples. A similar upregulation of Lin28B was also observed in LN metastatic when compared with local tumors.

  2. suggest that molecular subtypes of the LIN-28B/let-7a/IGF-II axis associate with heterogeneous progression

  3. let-7 disruption by LIN28B, MYCN (show MYCN ELISA Kits) sponging, or genetic loss is a unifying mechanism of neuroblastoma (show ARHGEF16 ELISA Kits) development with broad implications for cancer pathogenesis

  4. elevated LIN28B expression as a hallmark of a novel fetal-like subgroup in Juvenile myelomonocytic leukemia.

  5. Lin28B/let-7 pathway is tightly regulated by macroH2A1 (show H2AFY ELISA Kits)

  6. Data show that RNA-binding protein (show PTBP1 ELISA Kits) LIN28B coordinates the expression of the oncogene (show RAB1A ELISA Kits) RAN protein and aurora A kinase (AURKA (show AURKA ELISA Kits)) in neuroblastoma (show ARHGEF16 ELISA Kits).

  7. Data implicate LIN28 (show LIN28A ELISA Kits)/RAS/MAP kinase (show MAPK1 ELISA Kits) as key drivers of tumorigenesis atypical teratoid rhabdoid tumors.

  8. The data implicate Lin28B as a novel oncogene (show RAB1A ELISA Kits) in melanomagenesis by mediating a miRNA regulatory circuit.

  9. LIN28 (show LIN28A ELISA Kits) and its regulatory microRNAs have roles in adult adrenocortical cancer

  10. A functional link between Lin28B and the uridylation pathway with a focus on let-7 metabolism in cancer cells.

Mouse (Murine) Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. data point toward a complex system of regulation by Lin28a (show LIN28A ELISA Kits), Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner

  2. Lin28B/let-7 axis acts as a critical driver of peripheral nervous system myelination

  3. These results implicate a key role for the LIN28B/let-7 axis in regulating postnatal supporting cell (show PTPRJ ELISA Kits) plasticity.

  4. Upregulation of LIN28B is associated with systemic mastocytosis.

  5. Lin28a (show LIN28A ELISA Kits) and Lin28b have overlapping functions in temporally regulating neural progenitor cell proliferation during early brain development.

  6. VH repertoire of Lin28b-induced BM B1a B cells differs from that of normal B1a, suggesting persisting differences from fetal progenitors.

  7. Our data imply dual repression of Let-7 during oocyte-embryo transition in the mouse model, the selective suppression of Let-7 biogenesis by Lin28 (show LIN28A ELISA Kits) homologs superimposed on previously reported global suppression of miRNA activity.

  8. Data implicate fetal expression of Lin28a (show LIN28A ELISA Kits)/b in the regulation of life-long effects on metabolism and growth.

  9. MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging

  10. intestine targeted expression of LIN28B causes intestinal hypertrophy, crypt expansion, and Paneth cell loss

LIN28B Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene names and symbols associated with LIN28B

  • lin-28 homolog B (C. elegans) (LIN28B) antibody
  • lin-28 homolog B (lin28b) antibody
  • lin-28 homolog B (LOC100221494) antibody
  • lin-28 homolog B (C. elegans) (Lin28b) antibody
  • 2810403D23Rik antibody
  • CSDD2 antibody
  • D030047M17Rik antibody
  • LIN-28 antibody
  • Lin-28.2 antibody

Protein level used designations for LIN28B

lin-28 homolog B (C. elegans) , lin-28 homolog B , Lin-28.2 , lin-28B , protein lin-28 homolog B

481943 Canis lupus familiaris
737588 Pan troglodytes
100216028 Xenopus (Silurana) tropicalis
100221494 Taeniopygia guttata
373796 Xenopus laevis
389421 Homo sapiens
380669 Mus musculus
421786 Gallus gallus
540646 Bos taurus
689054 Rattus norvegicus
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