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Lin-28 Homolog B (C. Elegans) Proteins (LIN28B)

The protein encoded by LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. Additionally we are shipping LIN28B Antibodies (76) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LIN28B 389421 Q6ZN17
LIN28B 380669 Q45KJ6
Rat LIN28B LIN28B 689054  
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Top LIN28B Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,641.83
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,647.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

LIN28B Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

Top referenced LIN28B Proteins

  1. Human LIN28B Protein expressed in Escherichia coli (E. coli) - ABIN1098417 : Heo, Joo, Cho, Ha, Han, Kim: Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. in Molecular cell 2008 (PubMed)
    Show all 2 references for ABIN1098417

More Proteins for Lin-28 Homolog B (C. Elegans) (LIN28B) Interaction Partners

Human Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. Compared with NCMT samples from the same OSCC patient, the expression of Lin28B was increased in all of the tumor samples. A similar upregulation of Lin28B was also observed in LN metastatic when compared with local tumors.

  2. suggest that molecular subtypes of the LIN-28B/let-7a/IGF-II axis associate with heterogeneous progression

  3. let-7 disruption by LIN28B, MYCN (show MYCN Proteins) sponging, or genetic loss is a unifying mechanism of neuroblastoma (show ARHGEF16 Proteins) development with broad implications for cancer pathogenesis

  4. elevated LIN28B expression as a hallmark of a novel fetal-like subgroup in Juvenile myelomonocytic leukemia.

  5. Lin28B/let-7 pathway is tightly regulated by macroH2A1 (show H2AFY Proteins)

  6. Data show that RNA-binding protein (show PTBP1 Proteins) LIN28B coordinates the expression of the oncogene (show RAB1A Proteins) RAN protein and aurora A kinase (AURKA (show AURKA Proteins)) in neuroblastoma (show ARHGEF16 Proteins).

  7. Data implicate LIN28 (show LIN28A Proteins)/RAS/MAP kinase (show MAPK1 Proteins) as key drivers of tumorigenesis atypical teratoid rhabdoid tumors.

  8. The data implicate Lin28B as a novel oncogene (show RAB1A Proteins) in melanomagenesis by mediating a miRNA regulatory circuit.

  9. LIN28 (show LIN28A Proteins) and its regulatory microRNAs have roles in adult adrenocortical cancer

  10. A functional link between Lin28B and the uridylation pathway with a focus on let-7 metabolism in cancer cells.

Mouse (Murine) Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. data point toward a complex system of regulation by Lin28a (show LIN28A Proteins), Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner

  2. Lin28B/let-7 axis acts as a critical driver of peripheral nervous system myelination

  3. These results implicate a key role for the LIN28B/let-7 axis in regulating postnatal supporting cell (show PTPRJ Proteins) plasticity.

  4. Upregulation of LIN28B is associated with systemic mastocytosis.

  5. Lin28a (show LIN28A Proteins) and Lin28b have overlapping functions in temporally regulating neural progenitor cell proliferation during early brain development.

  6. VH repertoire of Lin28b-induced BM B1a B cells differs from that of normal B1a, suggesting persisting differences from fetal progenitors.

  7. Our data imply dual repression of Let-7 during oocyte-embryo transition in the mouse model, the selective suppression of Let-7 biogenesis by Lin28 (show LIN28A Proteins) homologs superimposed on previously reported global suppression of miRNA activity.

  8. Data implicate fetal expression of Lin28a (show LIN28A Proteins)/b in the regulation of life-long effects on metabolism and growth.

  9. MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging

  10. intestine targeted expression of LIN28B causes intestinal hypertrophy, crypt expansion, and Paneth cell loss

LIN28B Protein Profile

Protein Summary

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene names and symbols associated with LIN28B

  • lin-28 homolog B (C. elegans) (LIN28B)
  • lin-28 homolog B (lin28b)
  • lin-28 homolog B (LOC100221494)
  • lin-28 homolog B (C. elegans) (Lin28b)
  • 2810403D23Rik protein
  • CSDD2 protein
  • D030047M17Rik protein
  • LIN-28 protein
  • Lin-28.2 protein

Protein level used designations for LIN28B

lin-28 homolog B (C. elegans) , lin-28 homolog B , Lin-28.2 , lin-28B , protein lin-28 homolog B

GENE ID SPECIES
481943 Canis lupus familiaris
737588 Pan troglodytes
100216028 Xenopus (Silurana) tropicalis
100221494 Taeniopygia guttata
373796 Xenopus laevis
389421 Homo sapiens
380669 Mus musculus
421786 Gallus gallus
540646 Bos taurus
689054 Rattus norvegicus
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