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anti-Lin-28 Homolog B (C. Elegans) (LIN28B) Antibodies

The protein encoded by LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. Additionally we are shipping LIN28B Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LIN28B 389421 Q6ZN17
LIN28B 380669 Q45KJ6
LIN28B 689054  
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Top anti-LIN28B Antibodies at antibodies-online.com

Showing 10 out of 77 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of anti-LIN28B Pab (ABIN388297) in K562 cell line lysates (35 µg/lane). LIN28B(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human testis tissue reacted with LIN28B antibody (Center) (ABIN388297), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of LIN28B Antibody (N-term) (ABIN388295) in HL60 cell line lysates (35 µg/lane). LIN28B (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human Testis tissue reacted with LIN28B Antibody (N-term)(ABIN388295), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of LIN28B Antibody (C-term) in HL60 cell line lysates (35 µg/lane). LIN28B (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Flow cytometric analysis of HL-60 cells using LIN28B Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Spleen (formalin-fixed, paraffin-embedded) stained with LIN28Bfollowed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Testis (formalin-fixed, paraffin-embedded) stained with LIN28Bfollowed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC, WB Western blot analysis of extracts of HEK-293 cells, using LIN28B antibody. 100 μL Log in to see 14 Days
$275.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western Blot: LIN-28B Antibody [NBP1-50529] - Analysis of anti-LIN28B antibody with HL60 cell line lysates (35ug/lane). Immunohistochemistry-Paraffin: LIN-28B Antibody [NBP1-50529] - Analysis of anti-LIN28B antibody with human spleen at concentration 10 ug/ml. 0.05 mg Log in to see 10 to 13 Days
$447.56
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Raji cell lysates probed with Rabbit Anti-Lin-28B Polyclonal Antibody, Unconjugated (ABIN1387887) at 1:300 in 4˚C. Followed by conjugation to secondary antibody at 1:5000 90min in 37˚C. 100 μL Log in to see 3 to 7 Days
$295.90
Details

LIN28B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-LIN28B Antibodies

  1. Human Polyclonal LIN28B Primary Antibody for FACS, IF - ABIN388295 : Guo, Chen, Ito, Watanabe, Ge, Kodama, Aburatani: Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. in Gene 2006 (PubMed)
    Show all 2 references for ABIN388295

  2. Human Polyclonal LIN28B Primary Antibody for FACS, WB - ABIN388296 : Beachy, Onozawa, Chung, Slape, Bilke, Francis, Pineda, Walker, Meltzer, Aplan: Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. in Blood 2012 (PubMed)
    Show all 2 references for ABIN388296

  3. Human Polyclonal LIN28B Primary Antibody for FACS, IF - ABIN388297 : Mongroo, Noubissi, Cuatrecasas, Kalabis, King, Johnstone, Bowser, Castells, Spiegelman, Rustgi: IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. in Cancer research 2011 (PubMed)
    Show all 2 references for ABIN388297

More Antibodies against LIN28B Interaction Partners

Human Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. Upregulation of let-7a carries the potential to reverse CCL18 (show CCL18 Antibodies) induced cell proliferation and migration alteration in breast cancer cells by regulating Lin28 (show LIN28A Antibodies) expression.

  2. LIN28B orchestrates oncogenic signaling in neuroblastoma (show ARHGEF16 Antibodies).

  3. loss of SIRT6 (show SIRT6 Antibodies) results in hyperacetylation of H3K9 and H3K56 at the promoter of the LIN28B gene, creating a more permissive chromatin state and allowing for the Myc (show MYC Antibodies) transcription factor to drive its expression

  4. Compared with NCMT samples from the same OSCC patient, the expression of Lin28B was increased in all of the tumor samples. A similar upregulation of Lin28B was also observed in LN metastatic when compared with local tumors.

  5. suggest that molecular subtypes of the LIN-28B/let-7a/IGF-II axis associate with heterogeneous progression

  6. let-7 disruption by LIN28B, MYCN (show MYCN Antibodies) sponging, or genetic loss is a unifying mechanism of neuroblastoma (show ARHGEF16 Antibodies) development with broad implications for cancer pathogenesis

  7. elevated LIN28B expression as a hallmark of a novel fetal-like subgroup in Juvenile myelomonocytic leukemia.

  8. Lin28B/let-7 pathway is tightly regulated by macroH2A1 (show H2AFY Antibodies)

  9. Data show that RNA-binding protein (show PTBP1 Antibodies) LIN28B coordinates the expression of the oncogene (show RAB1A Antibodies) RAN protein and aurora A kinase (AURKA (show AURKA Antibodies)) in neuroblastoma (show ARHGEF16 Antibodies).

  10. Data implicate LIN28 (show LIN28A Antibodies)/RAS/MAP kinase (show MAPK1 Antibodies) as key drivers of tumorigenesis atypical teratoid rhabdoid tumors.

Mouse (Murine) Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. data point toward a complex system of regulation by Lin28a (show LIN28A Antibodies), Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner

  2. Lin28B/let-7 axis acts as a critical driver of peripheral nervous system myelination

  3. These results implicate a key role for the LIN28B/let-7 axis in regulating postnatal supporting cell (show PTPRJ Antibodies) plasticity.

  4. Upregulation of LIN28B is associated with systemic mastocytosis.

  5. Lin28a (show LIN28A Antibodies) and Lin28b have overlapping functions in temporally regulating neural progenitor cell proliferation during early brain development.

  6. VH repertoire of Lin28b-induced BM B1a B cells differs from that of normal B1a, suggesting persisting differences from fetal progenitors.

  7. Our data imply dual repression of Let-7 during oocyte-embryo transition in the mouse model, the selective suppression of Let-7 biogenesis by Lin28 (show LIN28A Antibodies) homologs superimposed on previously reported global suppression of miRNA activity.

  8. Data implicate fetal expression of Lin28a (show LIN28A Antibodies)/b in the regulation of life-long effects on metabolism and growth.

  9. MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging

  10. intestine targeted expression of LIN28B causes intestinal hypertrophy, crypt expansion, and Paneth cell loss

LIN28B Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene names and symbols associated with LIN28B

  • lin-28 homolog B (C. elegans) (LIN28B) antibody
  • lin-28 homolog B (lin28b) antibody
  • lin-28 homolog B (LOC100221494) antibody
  • lin-28 homolog B (C. elegans) (Lin28b) antibody
  • 2810403D23Rik antibody
  • CSDD2 antibody
  • D030047M17Rik antibody
  • LIN-28 antibody
  • Lin-28.2 antibody

Protein level used designations for LIN28B

lin-28 homolog B (C. elegans) , lin-28 homolog B , Lin-28.2 , lin-28B , protein lin-28 homolog B

GENE ID SPECIES
481943 Canis lupus familiaris
737588 Pan troglodytes
100216028 Xenopus (Silurana) tropicalis
100221494 Taeniopygia guttata
373796 Xenopus laevis
389421 Homo sapiens
380669 Mus musculus
421786 Gallus gallus
540646 Bos taurus
689054 Rattus norvegicus
Selected quality suppliers for anti-LIN28B (LIN28B) Antibodies
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