Lin-28 Homolog B (C. Elegans) (LIN28B) ELISA Kits

The protein encoded by LIN28B belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. Additionally we are shipping LIN28B Antibodies (80) and LIN28B Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human LIN28B LIN28B 389421 Q6ZN17
Anti-Mouse LIN28B LIN28B 380669 Q45KJ6
Anti-Rat LIN28B LIN28B 689054  
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More ELISA Kits for LIN28B Interaction Partners

Human Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. LIN28A (show LIN28A ELISA Kits) and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.

  2. The identification of the let-7/Lin28 (show LIN28A ELISA Kits) axis as an important regulator of HSC (show FUT1 ELISA Kits) activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis

  3. the LIN28B rs221634 A>T polymorphism was associated with an increased neuroblastoma (show ARHGEF16 ELISA Kits) risk in Southern Chinese children.

  4. Upregulation of let-7a carries the potential to reverse CCL18 (show CCL18 ELISA Kits) induced cell proliferation and migration alteration in breast cancer cells by regulating Lin28 (show LIN28A ELISA Kits) expression.

  5. LIN28B orchestrates oncogenic signaling in neuroblastoma (show ARHGEF16 ELISA Kits).

  6. loss of SIRT6 (show SIRT6 ELISA Kits) results in hyperacetylation of H3K9 and H3K56 at the promoter of the LIN28B gene, creating a more permissive chromatin state and allowing for the Myc (show MYC ELISA Kits) transcription factor to drive its expression

  7. Compared with NCMT samples from the same OSCC patient, the expression of Lin28B was increased in all of the tumor samples. A similar upregulation of Lin28B was also observed in LN metastatic when compared with local tumors.

  8. suggest that molecular subtypes of the LIN-28B/let-7a/IGF-II axis associate with heterogeneous progression

  9. let-7 disruption by LIN28B, MYCN (show MYCN ELISA Kits) sponging, or genetic loss is a unifying mechanism of neuroblastoma (show ARHGEF16 ELISA Kits) development with broad implications for cancer pathogenesis

  10. elevated LIN28B expression as a hallmark of a novel fetal-like subgroup in Juvenile myelomonocytic leukemia.

Mouse (Murine) Lin-28 Homolog B (C. Elegans) (LIN28B) interaction partners

  1. this study shows that ectopic Lin28b expression reinitiates fetal regenerative potential in a subset of adult hematopoietic stem cells

  2. expression of the heterochronic factor Lin28b decreases in common myeloid progenitors during hematopoietic maturation to adulthood in mice.

  3. loss of Lin28b expression in fetal T cells leads to increased mature let-7, which causes decreased expression of TGF-betaRI, TGF-betaRIII, and SMAD2 (show SMAD2 ELISA Kits) proteins. A reduction in TGF-beta (show TGFB1 ELISA Kits) signaling leads to reduced Treg numbers.

  4. Lin28b positively regulates the expression of Lin28b itself and cell cycle-related proteins in hepatoblasts by suppressing the maturation of target microRNAs, lethal-7b and miR (show MLXIP ELISA Kits)-125a/b, enabling maintenance of the stem cell properties of hepatoblasts.

  5. LIN28A (show LIN28A ELISA Kits) and LIN28B play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.

  6. The identification of the let-7/Lin28 (show LIN28A ELISA Kits) axis as an important regulator of HSC (show FUT1 ELISA Kits) activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis

  7. data point toward a complex system of regulation by Lin28a (show LIN28A ELISA Kits), Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner

  8. Lin28B/let-7 axis acts as a critical driver of peripheral nervous system myelination

  9. These results implicate a key role for the LIN28B/let-7 axis in regulating postnatal supporting cell (show PTPRJ ELISA Kits) plasticity.

  10. Upregulation of LIN28B is associated with systemic mastocytosis.

LIN28B Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

Gene names and symbols associated with LIN28B

  • lin-28 homolog B (C. elegans) (LIN28B) antibody
  • lin-28 homolog B (lin28b) antibody
  • lin-28 homolog B (LOC100221494) antibody
  • lin-28 homolog B (C. elegans) (Lin28b) antibody
  • 2810403D23Rik antibody
  • CSDD2 antibody
  • D030047M17Rik antibody
  • LIN-28 antibody
  • Lin-28.2 antibody

Protein level used designations for LIN28B

lin-28 homolog B (C. elegans) , lin-28 homolog B , Lin-28.2 , lin-28B , protein lin-28 homolog B

GENE ID SPECIES
481943 Canis lupus familiaris
737588 Pan troglodytes
100216028 Xenopus (Silurana) tropicalis
100221494 Taeniopygia guttata
373796 Xenopus laevis
389421 Homo sapiens
380669 Mus musculus
421786 Gallus gallus
540646 Bos taurus
689054 Rattus norvegicus
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