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Lipoprotein-Associated phospholipase A2 Proteins (Lp-PLA2)

The protein encoded by Lp-PLA2 is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Additionally we are shipping Lipoprotein-Associated phospholipase A2 Antibodies (89) and Lipoprotein-Associated phospholipase A2 Kits (74) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Lp-PLA2 7941 Q13093
Rat Lp-PLA2 Lp-PLA2 301265  
Lp-PLA2 27226 Q60963
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Top Lipoprotein-Associated phospholipase A2 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Dog His tag 100 μg Log in to see 11 to 13 Days
$932.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$633.60
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$4,292.36
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$510.36
Details

Lp-PLA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
,
Mouse (Murine)

Top referenced Lipoprotein-Associated phospholipase A2 Proteins

  1. Human Lp-PLA2 Protein expressed in Human Cells - ABIN2003487 : Yamada, Ichihara, Fujimura, Yokota: Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men. in Metabolism: clinical and experimental 1998 (PubMed)
    Show all 4 references for ABIN2003487

More Proteins for Lipoprotein-Associated phospholipase A2 (Lp-PLA2) Interaction Partners

Human Lipoprotein-Associated phospholipase A2 (Lp-PLA2) interaction partners

  1. Increased plasma Lp-PLA2 activity portends increased risk of resistant hypertension.

  2. These findings suggest that plasma PAF (show KIAA0101 Proteins) may be a potential biomarker for predicting poor bone health in postmenopausal women.

  3. Studied whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis.

  4. Higher Lp-PLA2 mass and activity were associated with development of both incident clinical peripheral arterial disease and low ankle brachial index.

  5. A V279F loss-of-function variant in the PLA2G7 gene resulting in 50% lower activity for each copy of the variant, is common in East Asians and associated with risk of Vascular diseases.

  6. It is assumed that Lp-PLA2 is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA2 itself.

  7. Cytosolic phospholipase A2 modulates TLR2 signaling in synoviocytes.

  8. Lipoprotein associated phospholipase A2 activity and apolipoprotein C3 (show APOC3 Proteins) loss-of-function variants are involved in cardiovascular disease

  9. The study indicated that the A379V variant in PLA2G7 gene might contribute to ischemic stroke susceptibility in northern Chinese Han population.

  10. The presence of subclinical coronary atherosclerosis is associated independently with Lp-PLA2, and it has potential utility as a novel indicator of cardiovascular disease risk in the young adult population.

Mouse (Murine) Lipoprotein-Associated phospholipase A2 (Lp-PLA2) interaction partners

  1. Lp-PLA2 augments the inflammatory response after MI and antagonizes healing by disrupting the balance between inflammation and repair.

  2. Plg (show PLG Proteins) from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2), suggesting that linkage to Plg (show PLG Proteins) protects oxPtdPCs from metabolism during their transport in the plasma.

  3. SAA (show SAA1 Proteins) up-regulates Lp-PLA2 production significantly via a FPRL1 (show FPR2 Proteins)/MAPKs./PPAR-gamma (show PPARG Proteins) signaling pathway.

  4. Deletion of Pla2g7 decreases small intestinal polyp and colon tumor incidence in ApcMin/+ mice.

  5. Macrophage VLDL receptor (show VLDLR Proteins) promotes PAFAH (show PAFAH1B1 Proteins) secretion in mother's milk and suppresses systemic inflammation in nursing neonates.

  6. Pla2g7 and Tnfrsf21 (show TNFRSF21 Proteins) have been identified as genetic susceptibility to influenza genes in mice.

  7. Pla2g7 plays a crucial physiological role in smooth muscle cell differentiation from stem cells, and interactions between Nrf3 (show NFE2L3 Proteins) and Pla2g7 are essential.

  8. The effects of a specific lp-PLA2 inhibitor on atherosclerosis in ApoE (show APOE Proteins)-deficient mice and its associated mechanisms, are reported.

  9. Studies designed to evaluate the ability of precursor forms of PAF-AH to mature to fully active proteins indicated that the N-terminal end of human and mouse PAF-AH played important and opposite roles in this process.

  10. PAF acetylhydrolase activity in the uterus in early pregnancy was not produced locally but probably resulted from the influx of the plasma form of the enzyme

Pig (Porcine) Lipoprotein-Associated phospholipase A2 (Lp-PLA2) interaction partners

  1. The results demonstrated that Lp-PLA2 is associated with triglycerides which may be helpful for understanding the relationship of this protein with cardiovascular disease.

  2. Effect of splenectomy and autologous spleen transplantation on the serum PAF-AH activity and acute-phase response in a porcine model are reported.

  3. observations support a proatherogenic role for Lp-PLA2

  4. Variable gene expression (eg, matrix metalloproteinase-9 (show MMP9 Proteins), CCL2 (show CCL2 Proteins) and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.

  5. The significant correlation between PLA2G7 RNA expression in plaque macrophages and plasma PAFAH activity suggests that the latter is a consequence, rather than a cause of macrophage accumulation.

Lipoprotein-Associated phospholipase A2 (Lp-PLA2) Protein Profile

Protein Summary

The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Lp-PLA2

  • phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (PLA2G7)
  • phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (Pla2g7)
  • LDL-PLA2 protein
  • Lp-PLA2 protein
  • PAF-AH protein
  • PAFAD protein
  • PAFAH protein
  • R75400 protein

Protein level used designations for Lp-PLA2

1-alkyl-2-acetylglycerophosphocholine esterase , 2-acetyl-1-alkylglycerophosphocholine esterase , LDL-PLA(2) , LDL-associated phospholipase A2 , PAF 2-acylhydrolase , PAF acetylhydrolase , gVIIA-PLA2 , group-VIIA phospholipase A2 , lipoprotein-associated phospholipase A2 , platelet-activating factor acetylhydrolase , Paf-acetylhydrolase , group VII phospholipase A2 , plasma PAF acetylhydrolase

GENE ID SPECIES
7941 Homo sapiens
301265 Rattus norvegicus
27226 Mus musculus
100135600 Cavia porcellus
396593 Sus scrofa
403848 Canis lupus familiaris
282311 Bos taurus
395816 Gallus gallus
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