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Lon Peptidase 1, Mitochondrial (LONP1) ELISA Kits

LONP1 encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. Additionally we are shipping Lon Peptidase 1, Mitochondrial Antibodies (50) and Lon Peptidase 1, Mitochondrial Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human LONP1 LONP1 9361 P36776
Anti-Mouse LONP1 LONP1 74142 Q8CGK3
Anti-Rat LONP1 LONP1 170916 Q924S5
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More ELISA Kits for Lon Peptidase 1, Mitochondrial Interaction Partners

Human Lon Peptidase 1, Mitochondrial (LONP1) interaction partners

  1. Mutations of Lon, which likely impair its chaperone properties, are at the basis of a genetic inherited disease named the cerebral, ocular, dental, auricular, skeletal (CODAS) syndrome. (Review)

  2. Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells.

  3. Lon downregulation attenuated hypoxia-induced cardiomyocyte apoptosis through a reduction of reactive oxygen species level.

  4. LONP1 encodes an enzyme of bacterial ancestry that participates in protein turnover within the mitochondrial matrix, and mutations in its ATP-binding and proteolytic domains cause CODAS syndrome.

  5. A review on the recent discoveries concerning Lon Protease functions. [review]

  6. These results suggest that the mechanism underlying cell survival regulated by Lon is mediated by the maintenance of the protein stability of Hsp60 (show HSPD1 ELISA Kits)-mtHsp70 (show HSPA9 ELISA Kits) complex.

  7. Silencing of SIRT3 (show SIRT3 ELISA Kits) increased the levels of Lon protein and of its acetylation, suggesting that Lon is a target of SIRT3 (show SIRT3 ELISA Kits), likely at K917.

  8. We establish a link between LONP1 and CODAS syndrome in humans.

  9. Lonp1 has a protective role against ochratoxin a induced cytotoxicity in kidney cells.

  10. StAR proteolysis is executed by at least 2 mitochondrial proteases, the matrix LON protease and the inner membrane complexes of the metalloproteases AFG3L2 (show AFG3L2 ELISA Kits) and AFG3L2 (show AFG3L2 ELISA Kits):SPG7/paraplegin (show SPG7 ELISA Kits).

Mouse (Murine) Lon Peptidase 1, Mitochondrial (LONP1) interaction partners

  1. LONP1 knockdown inhibits cellular proliferation and tumor and metastasis formation, whereas its overexpression increases tumorigenesis.

  2. Epidermal growth factor (show EGF ELISA Kits) up-regulates the transcription of ATP-dependent protease through extracellular signal-regulated protein kinase (show CDK7 ELISA Kits)- and 1-phosphatidylinositol 3-kinase (show PIK3CG ELISA Kits)-dependent pathways.

  3. Modulation of Lon protease activity during aging and oxidative stress.

  4. The correlative effect of Lon and ClpP (show CLPP ELISA Kits) upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP (show CLPP ELISA Kits) proteases in FRDA (show FXN ELISA Kits).

Lon Peptidase 1, Mitochondrial (LONP1) Antigen Profile

Antigen Summary

This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with LONP1

  • lon peptidase 1, mitochondrial (LONP1) antibody
  • lon peptidase 1, mitochondrial (lonp1) antibody
  • lon peptidase 1, mitochondrial (Lonp1) antibody
  • Mitochondrial protease (PIM1) antibody
  • 1200017E13Rik antibody
  • fc64d11 antibody
  • hLON antibody
  • Lon antibody
  • LonHS antibody
  • LONP antibody
  • PIM1 antibody
  • Prss15 antibody
  • wu:fc64d11 antibody

Protein level used designations for LONP1

lon peptidase 1, mitochondrial , protease, serine, 15 , lon protease homolog, mitochondrial-like , hLON ATP-dependent protease , lon protease homolog, mitochondrial , mitochondrial ATP-dependent protease Lon , mitochondrial lon protease-like protein , serine protease 15 , LONP , lon protease-like protein , ATP-dependent Lon protease , hypothetical protein

455623 Pan troglodytes
563257 Danio rerio
100024990 Monodelphis domestica
100074993 Ornithorhynchus anatinus
100408135 Callithrix jacchus
100468447 Ailuropoda melanoleuca
100538450 Meleagris gallopavo
100590941 Nomascus leucogenys
9361 Homo sapiens
74142 Mus musculus
170916 Rattus norvegicus
768942 Gallus gallus
611425 Canis lupus familiaris
100511917 Sus scrofa
510796 Bos taurus
3640999 Candida albicans SC5314
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