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LOR encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Additionally we are shipping Loricrin Antibodies (19) and Loricrin Kits (7) and many more products for this protein.
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Authors report a multi-generation family with prominent ichthyosis (show LBR Proteins) and palmoplantar involvement due to a novel mutation in loricrin.
Letter: Knockdown of either filaggrin (show FLG Proteins) or loricrin increases the productions of interleukin (IL)-1alpha, IL-8 (show IL8 Proteins), IL-18 (show IL18 Proteins) and granulocyte macrophage colony-stimulating factor (show CSF2 Proteins) in stratified human keratinocytes.
Studies on human keratinocytes recognized that loricrin expression was inversely related to the expression of the cyclin-dependent kinase (show CDK1 Proteins) inhibitor p21 (show CDKN1A Proteins)
two novel heterozygous frameshift mutations in exon 2 - c.646_647insGCAGCAGGTC, p.Gln216Argfs*123 and c.798_799dupT, p.Gly267Trpfs*69 in loricrin keratoderma patients
Results describe a novel frameshift mutation leading to loricrin keratoderma presenting with colloidion membrane
We found no mutations of Loricrin in two Progressive symmetrical erythrokeratoderma families.
We describe a young man who was a collodion baby and had the typical presentation of Loricrin keratoderma. Direct DNA sequencing identified a heterozygous mutation in the loricrin gene with a single G insertion, 730insG, present in (a) the patient
There were no mutations found in the LOR gene and the true pathogenesis of progressive symmetrical erythrokeratodermia remains unknown.
identified mRNA transcripts from three genes CDSN (show CDSN Proteins), LOR and KRT9 (show KRT9 Proteins), showing strong over-expression in skin samples relative to samples from forensic body fluids, making them suitable markers for skin identification
VEGF (show VEGFA Proteins) release and the subsequent activation of VEGF receptor 2 link loricrin gene mutations to rapid cell proliferation in a cellular model of loricrin keratoderma.
the late cornified envelope 1 proteins are regulated by NRF2 (show NFE2L2 Proteins) and are compensatory components for loricrin as determined by their localization within the loricrin knockout cell envelope via immunoelectron microscopy
Oct-6 and Oct-11 contribute to the regulation of loricrin gene transcription via interaction with AP-1 factors and Sp1/Sp3.
In the absence of loricrin, S. aureus nasal colonisation was significantly impaired.
The decreased expression of epidermal growth factor receptor (EGFR (show EGFR Proteins)), E-cadherin (show CDH1 Proteins), occludin (show OCLN Proteins), and SIRT1 (show SIRT1 Proteins) in the skin of Flg(ft (show FLG Proteins)) mice, compared with those in C57BL/6J mice, is reported.
YY1 (show YY1 Proteins) contributes to specific loricrin gene expression in differentiated keratinocytes by suppression of its transcription in undifferentiated keratinocytes.
nectin-1 (show PVRL1 Proteins) plays a key role in the expression of loricrin in the epidermis
Skin biopsies from STAT6 (show STAT6 Proteins) transgenic mice were deficient in the expression and production of loricrin and involucrin (show IVL Proteins).
These results indicate AASS (show AASS Proteins) knockdown decreases the lysine requirement of the cell via a reduction of lysine catabolism through the saccharopine pathway.
Mice receiving the high-protein diet had greater AASS (show AASS Proteins) mRNA compared to mice fed the adequate protein diet.
This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.
, alpha-aminoadipic semialdehyde synthase, mitochondrial
, lysine oxoglutarate reductase
, saccharopine dehydrogenase