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Low Density Lipoprotein Receptor Proteins (LDLR)

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Additionally we are shipping LDLR Antibodies (128) and LDLR Kits (45) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LDLR 3949 P01130
LDLR 16835 P35951
LDLR 300438 P35952
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Top LDLR Proteins at antibodies-online.com

Showing 10 out of 27 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$385.00
Details
HOST_HEK-293 Mouse Un-conjugated 100 μg Log in to see 10 to 12 Days
$641.36
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_HEK-293 Human Un-conjugated 100 μg Log in to see 10 to 12 Days
$641.36
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
$756.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details

LDLR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, , , , , ,
Mouse (Murine) , , , ,
,
Rat (Rattus)

Top referenced LDLR Proteins

  1. Mouse (Murine) LDLR Protein expressed in Human Cells - ABIN2007638 : Südhof, Goldstein, Brown, Russell: The LDL receptor gene: a mosaic of exons shared with different proteins. in Science (New York, N.Y.) 1985 (PubMed)
    Show all 4 references for ABIN2007638

  2. Human LDLR Protein expressed in HEK-293 - ABIN2666986 : Bieghs, Van Gorp, Wouters, Hendrikx, Gijbels, van Bilsen, Bakker, Binder, Lütjohann, Staels, Hofker, Shiri-Sverdlov: LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. in PLoS ONE 2012 (PubMed)
    Show all 4 references for ABIN2666986

  3. Mouse (Murine) LDLR Protein expressed in HEK-293 - ABIN2666847 : Brown, Goldstein: How LDL receptors influence cholesterol and atherosclerosis. in Scientific American 1985 (PubMed)
    Show all 4 references for ABIN2666847

  4. Human LDLR Protein expressed in HEK-293 Cells - ABIN2181455 : Nomura, Merched, Nour, Dieker, Oka, Chan: Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia. in Gene therapy 2004 (PubMed)

More Proteins for Low Density Lipoprotein Receptor (LDLR) Interaction Partners

Human Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. Specifically, loss of IDOL (show MYLIP Proteins) increases LDLR distribution in the hepatic cell, and subsequently reduces serum LDL-C levels in dyslipidemic patients.

  2. de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia

  3. A recurrent frameshift mutation in LDLR gene causing familial hypercholesterolemia was identified in 9 probands and their relatives.

  4. LDL receptor gene polymorphisms play a role in the treatment response of hepatitis C and the modulation of disease progression in Egyptians infected with chronic HCV.

  5. This study aimed to perform a systematic review of LDLR mutations in China.

  6. miR (show MLXIP Proteins)-185 controls cholesterol homeostasis as a key posttranscriptional LDLR modulator in hepatic cells, providing novel insight into the regulatory mechanism for LDLR expression and the anti-atherosclerosis effect of miR (show MLXIP Proteins)-185-inhibitor.

  7. Three polymorphisms in the 3' UTR region of LDLR, c.*52G>A, c.*504G>A, and c.*773A>G, and two at the 5' UTR region of PCSK9 (show PCSK9 Proteins), c.-3383C>G and c.-2063A>G, were associated with response to Armolipid Plus

  8. in well characterized FCHL (show USF1 Proteins) individuals, variants in LDLR and LPL (show LCP1 Proteins) provide a small contribution to dyslipidemia

  9. MicroRNA-27a has a role in decreasing the level and efficiency of the LDL receptor and contributes to the dysregulation of cholesterol homeostasis

  10. Data suggest inducible expression of IDOL (show MYLIP Proteins) is subject to robust, rapid regulation by process that is sensitive to deubiquitinase inhibition in human/mouse cell lines and primary human cells; transcriptional induction of IDOL (show MYLIP Proteins) leads to degradation of LDLR.

Cow (Bovine) Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE (show APOE Proteins), MTP (show MTTP Proteins), and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.

Mouse (Murine) Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. Neurometabolic roles of ApoE (show APOE Proteins) and Ldl-R in mouse brain.

  2. Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model.

  3. Suggest Idol (show MYLIP Proteins) as a gatekeeper of LDLR-dependent ApoE (show APOE Proteins) and Abeta (show APP Proteins) clearance in the brain and a potential enzyme target for therapeutic intervention in Alzheimer disease.

  4. binding of PCSK9 (show PCSK9 Proteins) to GRP94 (show HSP90B1 Proteins) protects LDLR from degradation likely by preventing early binding of PCSK9 (show PCSK9 Proteins) to LDLR

  5. Short-term modulation of miR (show MLXIP Proteins)-27b expression in wild-type mice regulates hepatic LDLR and ABCA1 (show ABCA1 Proteins) expression but does not influence plasma and hepatic lipid levels.

  6. miR (show MLXIP Proteins)-185 controls cholesterol homeostasis as a key posttranscriptional LDLR modulator in hepatic cells, providing novel insight into the regulatory mechanism for LDLR expression and the anti-atherosclerosis effect of miR (show MLXIP Proteins)-185-inhibitor.

  7. The absence of PCSK9 (show PCSK9 Proteins) results in a sex- and tissue-specific subcellular distribution of the LDLR and VLDLR (show VLDLR Proteins), which is determined by estradiol levels.

  8. In the present study, we examined the effects of H2 on atherosclerotic plaque stability and the underlying mechanisms in low-density lipoprotein receptor-knockout (LDLR-/-) mice and macrophage-derived foam cell models.

  9. Targeted deletion of ChREBP (show MLXIPL Proteins) in bone marrow cells resulted in accelerated atherosclerosis progression in Ldlr-/- mice with increased monocytosis, lesional macrophage accumulation, and plaque necrosis.

  10. Blockade of Tim-1 (show HAVCR1 Proteins) and Tim-4 (show TIMD4 Proteins) enhances atherosclerosis in LDL receptor knockout mice.

Pig (Porcine) Low Density Lipoprotein Receptor (LDLR) interaction partners

  1. The LDLR gene should be a candidate causative gene for LDL-cholesterol and total cholesterol in pigs, but heterogeneity exists in different populations.

  2. KLF13 (show KLF13 Proteins) and SREBP-Sp1 (show SP1 Proteins) activation interact to regulate low density lipoprotein receptor promoter function

  3. found association between genotypes for LDLR and APOB (show APOB Proteins) polymorphisms and serum lipid levels, but none of them seem to be the causal mutation but probably represent closely linked polymorphisms

LDLR Protein Profile

Protein Summary

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with LDLR

  • low density lipoprotein receptor (ldlr)
  • low density lipoprotein receptor (LDLR)
  • low density lipoprotein receptor (Ldlr)
  • low density protein receptor (LOC443535)
  • FH protein
  • FHC protein
  • Hlb301 protein
  • LDLA protein
  • LDLCQ2 protein
  • LDLRA protein

Protein level used designations for LDLR

low-density lipoprotein receptor , LDL receptor , low-density lipoprotein receptor class A domain-containing protein 3 , low density lipoprotein receptor (familial hypercholesterolemia)

GENE ID SPECIES
387529 Danio rerio
3949 Homo sapiens
281276 Bos taurus
100009086 Oryctolagus cuniculus
16835 Mus musculus
300438 Rattus norvegicus
100724238 Cavia porcellus
396801 Sus scrofa
100683160 Canis lupus familiaris
395103 Gallus gallus
100689399 Cricetulus griseus
443535 Ovis aries
Selected quality suppliers for LDLR Proteins (LDLR)
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