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Low Density Lipoprotein Receptor Adaptor Protein 1 Proteins (LDLRAP1)

The protein encoded by LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. Additionally we are shipping LDLRAP1 Antibodies (123) and LDLRAP1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LDLRAP1 26119 Q5SW96
LDLRAP1 100017 Q8C142
Rat LDLRAP1 LDLRAP1 500564  
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Top LDLRAP1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,825.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

LDLRAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced LDLRAP1 Proteins

  1. Human LDLRAP1 Protein expressed in Escherichia coli (E. coli) - ABIN668020 : Mishra, Keyel, Edeling, Dupin, Owen, Traub: Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN668020

More Proteins for Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) Interaction Partners

Human Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) interaction partners

  1. Numb (show NUMB Proteins) specifically regulates NPC1L1 (show NPC1L1 Proteins)-mediated cholesterol absorption both in human intestine and liver, distinct from ARH and Dab2 (show DAB2 Proteins), which selectively participate in LDLR (show LDLR Proteins)-mediated LDL uptake.

  2. Identification of ARH gene and characterization of its mutations in Autosomal Recessive Hypercholesterolemia patients [Review]

  3. cells that depend upon ARH for LDL uptake can control which lipoproteins are internalized by their LDLRs through changes in nitric oxide.

  4. This work identified a combined LDL receptor (show LDLR Proteins) and LDLRAP1 mutation as the cause for severe familial hypercholesterolemia in a family of Turkish descent.

  5. The report provides evidence that endocytosis of the ROMK potassium channel is controlled by LDLRAP1 (ARH). ROMK binds directly to the LDLRAP1, and this interaction is mediated by a novel variant of the canonical "NPXY" endocytotic signal, YxNPxFV. LDLRAP1-knockout mice are unable to physiologically regulate ROMK.

  6. report the crystal structure at 1.37-A resolution of the phosphotyrosine-binding (PTB (show PTBP1 Proteins)) domain of ARH in complex with an LDLR (show LDLR Proteins) tail peptide containing the FxNPxY(0) internalization signal

  7. LDL receptor (show LDLR Proteins)/LDLRAP1 double heterozygous mutations may account for severer phenotype in terms of xanthoma and atherosclerotic cardiovascular disease in familial hypercholesterolemia patients.

  8. ARH protein is involved in cell cycle progression, possibly by affecting nuclear membrane formation through interaction with lamin B1 (show LMNB1 Proteins) or other mitotic proteins, and its absence affects cell proliferation and induces premature senescence.

  9. Knockdown of ARH in polarized epithelial cells leads to specific apical missorting of truncated LDLR (show LDLR Proteins), which encodes only the FxNPxY motif (LDLR (show LDLR Proteins)-CT27 (show CTCFL Proteins)).

  10. newly identified a rare Thr56Met missense mutation located in the phosphotyrosine-binding domain of ARH; among 1,800 Japanese individuals, only 4 were heterozygous for Thr56Met and all had hypercholesterolemia resembling familiar hypercholesterolemia

Mouse (Murine) Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) interaction partners

  1. cells that depend upon ARH for LDL uptake can control which lipoproteins are internalized by their LDLRs through changes in nitric oxide.

  2. results are consistent with LDL receptor adaptor protein(ARH) playing a critical and specific role in low density lipoprotein receptor (show LDLR Proteins) endocytosis in the liver

  3. Hepatocytes do not take-up LDL in vivo without ARH protein, but they normally catabolize LDL in vitro. Thus, the requirement of ARH protein for proper functioning of the LDLR (show LDLR Proteins) is not cell-specific, but rather may depend on the cellular environment.

  4. the LDL receptor (show LDLR Proteins) alone can account for the clearance of apoE (show APOE Proteins)-containing lipoproteins in mice, and the contribution of other receptors is minimal, and b) defects in either increase the sensitivity to apoE (show APOE Proteins)-induced hypertriglyceridemia in mice.

  5. Taken together, our data suggest that ARH is a multifunctional protein whose spectrum of function in the brain goes beyond the traditionally known metabolism of lipoproteins, and that ARH may be locally synthesized in the axon.

  6. the endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis

  7. Loss of gamma-secretase function decreased endocytosis of low-density lipoprotein (LDL) receptor (show LDLR Proteins)

  8. ARH marks ROMK for clathrin-dependent endocytosis, in concert with the demands of potassium homeostasis

LDLRAP1 Protein Profile

Protein Summary

The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.

Gene names and symbols associated with LDLRAP1

  • low density lipoprotein receptor adaptor protein 1 (ldlrap1)
  • low density lipoprotein receptor adaptor protein 1 (LDLRAP1)
  • low density lipoprotein receptor adaptor protein 1 (LOC100342213)
  • low density lipoprotein receptor adaptor protein 1 (Ldlrap1)
  • low density lipoprotein receptor adaptor protein 1 (ldlrap1-b)
  • low density lipoprotein receptor adaptor protein 1 (ldlrap1-a)
  • low density lipoprotein receptor adaptor protein 1a (ldlrap1a)
  • AA691260 protein
  • Arh protein
  • Arh1 protein
  • ARH2 protein
  • FHCB1 protein
  • FHCB2 protein
  • ldlrap1 protein
  • RGD1563417 protein
  • sb:cb50 protein
  • xptb protein
  • zgc:56121 protein

Protein level used designations for LDLRAP1

low density lipoprotein receptor adaptor protein 1 , low-density lipoprotein adaptor protein , low density lipoprotein receptor adapter protein 1 , LDL receptor adaptor protein , autosomal recessive hypercholesterolemia protein , autosomal recessive hypercholesterolemia protein homolog , ARH beta , autosomal recessive hypercholesterolemia protein homolog beta , low density lipoprotein receptor adapter protein 1-B , xARH beta , ARH alpha , autosomal recessive hypercholesterolemia protein homolog alpha , low density lipoprotein receptor adapter protein 1-A , phosphotyrosine binding protein , phosphotyrosine-binding protein , xARH alpha , xcat4

GENE ID SPECIES
549868 Xenopus (Silurana) tropicalis
739347 Pan troglodytes
100125967 Sus scrofa
100342213 Oryctolagus cuniculus
511199 Bos taurus
26119 Homo sapiens
612219 Canis lupus familiaris
100017 Mus musculus
500564 Rattus norvegicus
414519 Xenopus laevis
419589 Gallus gallus
398568 Xenopus laevis
368278 Danio rerio
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