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The protein encoded by LRP2, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. Additionally we are shipping LRP2 Antibodies (53) and LRP2 Kits (9) and many more products for this protein.
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Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.
These studies implicate altered Lrp2-mediated homeostasis as important for myopia and other risk factors for glaucoma.
Megalin mediates transepithelial albumin (show ALB Proteins) clearance from the alveolar space of intact rabbit lungs
low-level LPS (show IRF6 Proteins)-mediated TNF-alpha (show TNF Proteins)-ERK1/2 signaling pathway is involved in downregulation of megalin expression in IRPTCs.
The megalin expression appears to vary inversely with gestational age with the greatest expression noted in the most premature samples. Age-dependent differences in placental megalin may therefore influence fetal exposure.
we are the first to identify the association between LRP2 and gout in a Chinese population and to confirm this association in Asians.
Two novel LRP2 mutations, a homozygous nonsense mutation and a missense mutation in two unrealted families with Donnai-Barrow syndrome.
Loss of LRP2 is associated with buphthalmos
melanoma cell expression of LRP2/megalin significantly decreases melanoma cell proliferation and survival rates.
levels of urinary C-megalin are associated with histological abnormalities in adult IgAN patients
A new mutation in LRP2 causes a predominantly ocular phenotype suggestive of Stickler syndrome.
LRP2 sequencing reveals multiple rare variants associated with urinary trefoil factor-3 (show TFF3 Proteins)
Serum uric acid-related gene LRP2 is not involved in gout susceptibility.
Transgenic/knock-out megalin-deficient mice develop anxiety behavior and impaired learning, as described in Alzheimer's disease.
Foxg1 (show FOXG1 Proteins)-Cre mediated Lrp2 inactivation in developing mouse neural retina, ciliary and retinal pigment epithelia is a model of congenital high myopia
megalin-deficient mice may provide a valuable model for future studies of megalin in ocular physiology and pathology.
LRP2 is essential for cellular folate uptake in the developing neural tube, a crucial step for proper neural tube closure.
we have identified hypothalamic clusterin (show CLU Proteins) as a novel anorexigenic molecule that can potentiate central leptin (show LEP Proteins) activity.
Multiligand endocytic receptor megalin may be involved in AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells.
SNPs in the CYP24A1 (show CYP24A1 Proteins), CYP2R1 (show CYP2R1 Proteins), calcium sensing receptor (CASR (show CASR Proteins)), vitamin D binding protein (GC (show GC Proteins)), retinoid X receptor-alpha (RXRA (show RXRA Proteins)) and megalin (LRP2) genes were significantly associated with pancreas cancer risk.
Lrp2 is a novel target gene by progesterone and progesterone receptor (show PGR Proteins).
The hypothalamic clusterin (show CLU Proteins)-low-density lipoprotein receptor-related protein-2 axis is a novel anorexigenic signalling pathway.
Data indicate that uptake of Sepp1 (show SEPP1 Proteins) and Gpx3 (show GPX3 Proteins) by d-13 visceral yolk sac (show ADCY10 Proteins) was independent of apoER2 (show LRP8 Proteins) and megalin.
megalin mutation causes Donnai-Barrow/Facio-Oculo-Acustico-Renal syndrome.
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
low density lipoprotein-related protein 2
, low-density lipoprotein receptor-related protein 2
, low density lipoprotein receptor-related protein 2
, low-density lipoprotein receptor-related protein 2-like
, Heymann nephritis antigen homolog
, calcium sensor protein
, glycoprotein 330