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Low Density Lipoprotein Receptor-Related Protein 2 Proteins (LRP2)

The protein encoded by LRP2, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. Additionally we are shipping LRP2 Antibodies (53) and LRP2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LRP2 4036 P98164
LRP2 14725 A2ARV4
Rat LRP2 LRP2 29216 P98158
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Top LRP2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

LRP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) Interaction Partners

Zebrafish Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.

  2. These studies implicate altered Lrp2-mediated homeostasis as important for myopia and other risk factors for glaucoma.

Rabbit Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. Megalin mediates transepithelial albumin (show ALB Proteins) clearance from the alveolar space of intact rabbit lungs

  2. low-level LPS (show IRF6 Proteins)-mediated TNF-alpha (show TNF Proteins)-ERK1/2 signaling pathway is involved in downregulation of megalin expression in IRPTCs.

Human Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 and TSPYL2 (show TSPYL2 Proteins) genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability

  2. The megalin expression appears to vary inversely with gestational age with the greatest expression noted in the most premature samples. Age-dependent differences in placental megalin may therefore influence fetal exposure.

  3. we are the first to identify the association between LRP2 and gout in a Chinese population and to confirm this association in Asians.

  4. Two novel LRP2 mutations, a homozygous nonsense mutation and a missense mutation in two unrealted families with Donnai-Barrow syndrome.

  5. Loss of LRP2 is associated with buphthalmos

  6. melanoma cell expression of LRP2/megalin significantly decreases melanoma cell proliferation and survival rates.

  7. levels of urinary C-megalin are associated with histological abnormalities in adult IgAN patients

  8. A new mutation in LRP2 causes a predominantly ocular phenotype suggestive of Stickler syndrome.

  9. LRP2 sequencing reveals multiple rare variants associated with urinary trefoil factor-3 (show TFF3 Proteins)

  10. Serum uric acid-related gene LRP2 is not involved in gout susceptibility.

Mouse (Murine) Low Density Lipoprotein Receptor-Related Protein 2 (LRP2) interaction partners

  1. Foxg1 (show FOXG1 Proteins)-Cre mediated Lrp2 inactivation in developing mouse neural retina, ciliary and retinal pigment epithelia is a model of congenital high myopia

  2. megalin-deficient mice may provide a valuable model for future studies of megalin in ocular physiology and pathology.

  3. LRP2 is essential for cellular folate uptake in the developing neural tube, a crucial step for proper neural tube closure.

  4. we have identified hypothalamic clusterin (show CLU Proteins) as a novel anorexigenic molecule that can potentiate central leptin (show LEP Proteins) activity.

  5. Multiligand endocytic receptor megalin may be involved in AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells.

  6. SNPs in the CYP24A1 (show CYP24A1 Proteins), CYP2R1 (show CYP2R1 Proteins), calcium sensing receptor (CASR (show CASR Proteins)), vitamin D binding protein (GC (show GC Proteins)), retinoid X receptor-alpha (RXRA (show RXRA Proteins)) and megalin (LRP2) genes were significantly associated with pancreas cancer risk.

  7. Lrp2 is a novel target gene by progesterone and progesterone receptor (show PGR Proteins).

  8. The hypothalamic clusterin (show CLU Proteins)-low-density lipoprotein receptor-related protein-2 axis is a novel anorexigenic signalling pathway.

  9. Data indicate that uptake of Sepp1 (show SEPP1 Proteins) and Gpx3 (show GPX3 Proteins) by d-13 visceral yolk sac (show ADCY10 Proteins) was independent of apoER2 (show LRP8 Proteins) and megalin.

  10. megalin mutation causes Donnai-Barrow/Facio-Oculo-Acustico-Renal syndrome.

LRP2 Protein Profile

Protein Summary

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Gene names and symbols associated with LRP2

  • low density lipoprotein receptor-related protein 2 (LRP2)
  • low density lipoprotein receptor-related protein 2a (lrp2a)
  • low-density lipoprotein receptor-related protein 2 (LRP2.3)
  • low density lipoprotein receptor-related protein 2 (lrp2)
  • low-density lipoprotein receptor-related protein 2-like (LOC100183506)
  • low density lipoprotein receptor-related protein 2 (Lrp2)
  • AI315343 protein
  • AW536255 protein
  • D230004K18Rik protein
  • DBS protein
  • Gp330 protein
  • im:680590 protein
  • lrp2 protein
  • Megalin protein

Protein level used designations for LRP2

low density lipoprotein-related protein 2 , gp330b , low-density lipoprotein receptor-related protein 2 , megalin , low density lipoprotein receptor-related protein 2 , low-density lipoprotein receptor-related protein 2-like , Heymann nephritis antigen homolog , LRP-2 , calcium sensor protein , glycoprotein 330 , gp330

GENE ID SPECIES
459713 Pan troglodytes
478781 Canis lupus familiaris
568184 Danio rerio
589778 Strongylocentrotus purpuratus
7232953 Branchiostoma floridae
100024150 Monodelphis domestica
100062836 Equus caballus
100126618 Xenopus laevis
100183506 Ciona intestinalis
100346275 Oryctolagus cuniculus
100403066 Callithrix jacchus
100455598 Pongo abelii
100475386 Ailuropoda melanoleuca
100489914 Xenopus (Silurana) tropicalis
100543626 Meleagris gallopavo
100558696 Anolis carolinensis
100591561 Nomascus leucogenys
4036 Homo sapiens
14725 Mus musculus
29216 Rattus norvegicus
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