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anti-Low Density Lipoprotein Receptor-Related Protein 2 Precursor (LRP2) Antibodies

The protein encoded by LRP2, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney.

list all antibodies Gene Name GeneID UniProt
Anti-Human LRP2 LRP2 4036 P98164
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More Antibodies against Low Density Lipoprotein Receptor-Related Protein 2 Precursor Interaction Partners

Human Low Density Lipoprotein Receptor-Related Protein 2 Precursor (LRP2) interaction partners

  1. homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 and TSPYL2 (show TSPYL2 Antibodies) genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability

  2. The megalin expression appears to vary inversely with gestational age with the greatest expression noted in the most premature samples. Age-dependent differences in placental megalin may therefore influence fetal exposure.

  3. we are the first to identify the association between LRP2 and gout in a Chinese population and to confirm this association in Asians.

  4. Two novel LRP2 mutations, a homozygous nonsense mutation and a missense mutation in two unrealted families with Donnai-Barrow syndrome.

  5. Loss of LRP2 is associated with buphthalmos

  6. melanoma cell expression of LRP2/megalin significantly decreases melanoma cell proliferation and survival rates.

  7. levels of urinary C-megalin are associated with histological abnormalities in adult IgAN patients

  8. A new mutation in LRP2 causes a predominantly ocular phenotype suggestive of Stickler syndrome.

  9. LRP2 sequencing reveals multiple rare variants associated with urinary trefoil factor-3 (show TFF3 Antibodies)

  10. Serum uric acid-related gene LRP2 is not involved in gout susceptibility.

Low Density Lipoprotein Receptor-Related Protein 2 Precursor (LRP2) Antigen Profile

Protein Summary

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

Gene names and symbols associated with LRP2

  • low density lipoprotein receptor-related protein 2 (LRP2) antibody
  • DBS antibody
  • GP330 antibody

Protein level used designations for LRP2

Heymann nephritis antigen homolog , LRP-2 , calcium sensor protein , glycoprotein 330 , low-density lipoprotein receptor-related protein 2 , megalin

GENE ID SPECIES
4036 Homo sapiens
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