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Low Density Lipoprotein Receptor-Related Protein 1 Proteins (LRP1)

The protein encoded by LRP1 is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. Additionally we are shipping LRP1 Antibodies (169) and LRP1 Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LRP1 4035 Q07954
LRP1 16971 Q91ZX7
Rat LRP1 LRP1 299858  
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Top LRP1 Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Un-conjugated 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$598.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 25 to 30 Days
$196.35
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days
$680.63
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 16 Days
$831.88
Details

LRP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)
,

Top referenced LRP1 Proteins

  1. Human LRP1 Protein expressed in Human Cells - ABIN2004497 : Su, Nakada-Tsukui, Tosello-Trampont, Li, Bu, Henson, Ravichandran: Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). in The Journal of biological chemistry 2002 (PubMed)
    Show all 4 references for ABIN2004497

More Proteins for Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) Interaction Partners

Human Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) interaction partners

  1. Considering that LRP-1, by mediating the clearance of matrix metalloproteinases, is involved in the regulation of extracellular matrix remodeling and cell migration, we conclude that a decreased expression of LRP-1 could be involved with the increasing activity of MMPs shown in cancers.

  2. These data suggest that the Rho/ROCK signaling pathway is involved in HIV-1 Tat (show TAT Proteins)-mediated changes in occludin (show OCLN Proteins), RAGE (show AGER Proteins), and LRP1 in human cerebral microvascular endothelial cells cells.

  3. Studies demonstrate a role for ADAM10 (show ADAM10 Proteins) in the ectodomain shedding of LRP1 in the brain and the clearance of Abeta (show APP Proteins) across the blood-brain barrier, which may provide a novel strategy for attenuating Abeta (show APP Proteins) accumulation in the AD brain

  4. Results provide evidence that TTR (show TTR Proteins) acts as a carrier of Abeta (show APP Proteins) at the blood-brain-barrier and liver, using LRP1.

  5. Studies show the ability of LRP1 to promote endocytosis and deliver cell signaling suggesting multiple roles in tumorigenesis and tumor progression. In addition, LRP1 has dual effects on tumor cell invasion and migration. Moreover, LRP1 can be regulated via methylation of its CpG islands. [review]

  6. Study demonstrated that 1,25(OH)2D3, the active form of vitamin D, plays an important role in increasing Abeta1-40 vectorial transport from the brain to blood and systemic clearance from peripheral circulation through increasing LRP1 levels both in vivo and in vitro, and reducing RAGE (show AGER Proteins) level in the blood-brain barrier model in vitro

  7. Circulating soluble LRP1 concentrations were associated with the occurrence of carotid atherosclerosis in a hypercholesterolemia population.

  8. LRP1 as a pathogenic gene for autosomal recessive Keratosis pilaris atrophicans and keratosis pilaris

  9. Suggest role for LRP1/PARP1 (show PARP1 Proteins) signaling in endothelial cell proliferation and retinal neovascularization induced by hypoxia.

  10. it was suggested that a cell surface-expressed beta-galactoside binding protein, galectin-8, was involved in factor V endocytosis.

Mouse (Murine) Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) interaction partners

  1. A critical role was determined for astrocytic LRP1 in brain for clearing amyloid-beta accumulation.

  2. Findings provide evidence for a central role of LRP1 in overall energy homeostasis, and specifically liver glucose and fatty acid metabolism. Its somatic inactivation in the liver predisposes to diet-induced insulin (show INS Proteins) resistance with dyslipidemia and non-alcoholic hepatic steatosis.

  3. Studies demonstrate a role for ADAM10 (show ADAM10 Proteins) in the ectodomain shedding of LRP1 in the brain and the clearance of Abeta (show APP Proteins) across the blood-brain barrier, which may provide a novel strategy for attenuating Abeta (show APP Proteins) accumulation in the AD brain

  4. Study demonstrated that 1,25(OH)2D3, the active form of vitamin D, plays an important role in increasing Abeta1-40 vectorial transport from the brain to blood and systemic clearance from peripheral circulation through increasing LRP1 levels both in vivo and in vitro, and reducing RAGE (show AGER Proteins) level in the blood-brain barrier model in vitro

  5. extracellular (alpha) chain (show FCGRT Proteins) of LRP1 mediates TGFbeta (show TGFB1 Proteins)-induced enhancement of Wnt5a (show WNT5A Proteins), which limits intracellular cholesterol accumulation.

  6. conclude that LRP1, NFkappaB, and miR (show MLXIP Proteins)-155 function as members of a previously unidentified system that has the potential to inhibit or sustain inflammation

  7. This study demonstrated that bexarotene rescues aging-related declines of synaptic proteins through a neural LRP1-mediated pathway presumably by increasing apoE (show APOE Proteins) levels and lipidation.

  8. LRP1 interacts with beta1-integrin mediating integrin internalization and thus correlates with downstream signaling of beta1-integrin such as focal adhesion dynamics.

  9. Selective deletion of Lrp1 in the brain endothelium of C57BL/6 mice strongly reduced brain efflux of injected [125I] Abeta (show APP Proteins)(1-42).

  10. Suggest role for LRP1/PARP1 (show PARP1 Proteins) signaling in endothelial cell proliferation and retinal neovascularization induced by hypoxia.

Pig (Porcine) Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) interaction partners

  1. Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.

  2. Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.

  3. Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.

LRP1 Protein Profile

Protein Summary

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.

Gene names and symbols associated with LRP1

  • low density lipoprotein receptor-related protein 1 (LRP1)
  • low density lipoprotein receptor-related protein 1 (Lrp1)
  • A2mr protein
  • AI316852 protein
  • APOER protein
  • APR protein
  • CD91 protein
  • IGFBP3R protein
  • Lrp protein
  • LRP-1 protein
  • LRP1A protein
  • TGFBR5 protein

Protein level used designations for LRP1

low density lipoprotein receptor-related protein 1 , prolow-density lipoprotein receptor-related protein 1-like , LRP-1 , TbetaR-V/LRP-1/IGFBP-3 receptor , alpha-2-macroglobulin receptor , apolipoprotein E receptor , prolow-density lipoprotein receptor-related protein 1 , type V tgf-beta receptor , alpha 2-macroglobulin receptor , lipoprotein receptor-related protein , low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) , low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor , low-density lipoprotein receptor-related protein 1

GENE ID SPECIES
100414789 Callithrix jacchus
4035 Homo sapiens
16971 Mus musculus
299858 Rattus norvegicus
100009547 Oryctolagus cuniculus
100726418 Cavia porcellus
100627964 Sus scrofa
481124 Canis lupus familiaris
533894 Bos taurus
396170 Gallus gallus
101120656 Ovis aries
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