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LRP8 encodes a member of the low density lipoprotein receptor (LDLR) family. Additionally we are shipping LRP8 Kits (10) and LRP8 Proteins (10) and many more products for this protein.
Showing 10 out of 93 products:
Human Polyclonal LRP8 Primary Antibody for EIA, IHC (p) - ABIN358640
Li, Kypreos, Zanni, Zannis: Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain. in Biochemistry 2003
Show all 4 references for 358640
Human Polyclonal LRP8 Primary Antibody for ELISA, WB - ABIN1452111
Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006
Cow (Bovine) Polyclonal LRP8 Primary Antibody for IHC, WB - ABIN2781990
Hoe, Minami, Makarova, Lee, Hyman, Matsuoka, Rebeck: Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. in The Journal of biological chemistry 2008
Chicken Polyclonal LRP8 Primary Antibody for ICC, IF - ABIN151639
Wang, Moerman-Herzog, Slaton, Barger: Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2. in Neurobiology of aging 2016
Human Monoclonal LRP8 Primary Antibody for ELISA, WB - ABIN563474
Liu, Wu, Baysarowich, Kavana, Addona, Bierilo, Mudgett, Pavlovic, Sitlani, Renger, Hubbard, Fisher, Zerbinatti: PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain. in Journal of lipid research 2010
The presence of reelin (show RELN Antibodies) was elevated in junctional areas as in dysplastic nevi. VLDLR (show VLDLR Antibodies) presented positive values in 16 cases (16/ 32) and ApoER2 was weak positive in 7 cases.
ApoER2 contributes cooperatively with endothelial cell protein C receptor (show PROCR Antibodies) and protease activated receptor 1 (show F2R Antibodies) to APC (show APC Antibodies)-initiated endothelial antiapoptotic and barrier protective signaling.
two SNPs (rs3737984 and rs2297660) in ApoER2 gene had significant association with dyslipidemia in Thai ethnic
A novel TACGC risk haplotype in the LRP8 gene that is present in patients with CAD (show CAD Antibodies) and MI but not in normal controls.
results of this study demonstrated the presence of reelin (show RELN Antibodies), its receptors VLDLR (show VLDLR Antibodies) and ApoER2 as well as Dab1 (show DAB1 Antibodies) in the ENS and might indicate a novel role of the reelin (show RELN Antibodies) system in regulating neuronal plasticity and pre-synaptic functions in the ENS.
Data suggest that PS1 (show PSEN1 Antibodies)/gamma-secretase-dependent processing of the reelin (show RELN Antibodies) receptor ApoER2 inhibits reelin (show RELN Antibodies) expression and may regulate its signaling.
ectopic expression of HIC1 (show HIC1 Antibodies) in U2OS and MDA-MB-231 cell lines decreases expression of the ApoER2 and VLDLR (show VLDLR Antibodies) genes, encoding two canonical tyrosine kinase (show TXK Antibodies) receptors for Reelin (show RELN Antibodies).
By incorporating the information from bioinformatics and RNA expression analyses, we identified at least two of the most promising risk genes for alcohol dependence: APOER2 and UBAP2 (show UBAP2 Antibodies)
TCCGC haplotype at the 3'-terminal block of the LRP8 gene confers a protective role in the development of familial and early-onset coronary artery disease and/or myocardial infarction.
In a Chinese unrelated Han population, variants within the LRP8 gene do not convey the risk of developing Parkinson's disease.
reveals a novel function for Reelin (show RELN Antibodies)/ApoER2 in peripheral nervous system, inducing cell migration of Schwann cells, a process relevant for peripheral nervous system development and regeneration
total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn (show FYN Antibodies)
This study demonstrated that ApoER2 is expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex.
This study demonistrated that LRP8-Reelin (show RELN Antibodies)-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation in mice.
Apoer2 lacking exon 16, the O-linked sugar domain, altered the proteolytic processing and abundance of Apoer2 in cells and synapse number and function in mice, hippocampal spine density, LTP (show SCP2 Antibodies), and cued fear learning.
genetic variants of apoE (show APOE Antibodies) and ApoER2 impact cardiovascular health by differentially modulating endothelial function.
Study shows that the levels of hippocampal ApoE (show APOE Antibodies) receptors Lrp1 (show LRP1 Antibodies) and Apoer2 in vivo are affected isoform specifically by ApoE4 and that the type of receptor affected is context dependent
Tandem Sepp1 (show SEPP1 Antibodies)-apoER2 interactions supply selenium for maintenance of brain neurons both at the blood-brain barrier and within the brain. Sepp1 (show SEPP1 Antibodies) inside the blood-brain barrier is taken up by neurons via apoER2, concentrating brain selenium in them.
data demonstrate that several multivalent ligands for ApoER2 induce clustering in transfected cells and primary neurons and that these complexes included other synaptic molecules, such as APP (show APP Antibodies) and PSD-95 (show DLG4 Antibodies)
Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis.
genetic variants of apoE (show APOE Antibodies) and ApoER2 impact cardiovascular health by differentially modulating endothelial function.[ApoER2]
the differential expression patterns of LRP8 mRNA during final follicular growth and ovulation
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
, low density lipoprotein receptor-related protein 8
, low-density lipoprotein receptor-related protein 8-like
, ApoE receptor 2
, low-density lipoprotein receptor-related protein 8
, apolipoprotein E receptor 2
, low density lipoprotein receptor relative, 8 ligand binding repeats, brain