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LYNX1 encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Additionally we are shipping Ly6/neurotoxin 1 Antibodies (2) and many more products for this protein.
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These findings provide new insights into the acetylcholine receptor (show CHRNA1 Proteins)-mediated regulatory mechanism of SLURP-2 expression in keratinocytes.
These studies suggest that lynx1 is a potential target both for development of drugs that may limit lung cancer growth as well as for drugs that may be effective for asthma or COPD (show ARCN1 Proteins) treatment.
This epigenome-wide DNA methylation (show HELLS Proteins) analysis in postmortem hippocampus and prefrontal cortex specimens confirmed LYNX1 DNA methylation (show HELLS Proteins) profiles in major depression.
SLURP-2 downregulated TNFalpha (show TNF Proteins) and IFNgamma R in T-cells and reduced IL-6 (show IL6 Proteins) production by macrophage
Micromolar affinities and fast washout rates measured for ws-LYNX1 and its mutants are in contrast to nanomolar affinities and irreversibility of binding for alpha-bungarotoxin and similar snake alpha-neurotoxins also targeting alpha7 nAChR (show CHRNA7 Proteins).
Computer modeling, based on ws-LYNX1 NMR structure and AChBP x-ray structure, revealed a possible mode of ws-LYNX1 binding.
These results indicated that SLURP-2 competes with acetylcholine predominantly at the alpha3 nAChR (show CHRNA4 Proteins), and that receptor ligation with SLURP-2 delays keratinocyte differentiation and prevents apoptosis.
LY-6K (show Ly6k Proteins),a novel member protein of the Ly-6/uPAR (show PLAUR Proteins) superfamily, is a significant new molecular marker for diagnosis and gene therapy in patients with breast cancer.
anti-tumorigenic activities of SLURP-1 (show SLURP1 Proteins) and -2 were demonstrated both in vitro and in vivo.
decreased Lynx1 is associated with squamous cell lung carcinoma
tPA (show PLAT Proteins) activity in V1 can be unmasked following 4 d of monocular deprivation when mice older than 2 months are raised in standard cages by the genetic removal of Lynx1, a negative regulator of adult plasticity.
lynx1 KO animals over 1 year of age have clear ultrastructural differences in the striatum.
Lynx1 has a role in shifting alpha4beta2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum
study identified an increase in expression of Lynx1 protein that prevented plasticity in the primary visual cortex late in life; Lynx1 expression maintains stability of mature cortical networks in the presence of cholinergic innervation
Results show that lynx1 colocalizes with nAChRs on CNS neurons and physically associates with nAChRs and enhances receptor desensitization, resulting in a novel type of functional modulation
Lynx1 appears to act as a negative modulator of alpha7 nAChR (show CHRNA7 Proteins)-induced events by inhibiting Src (show SRC Proteins) activation.
This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified.
Ly-6 neurotoxin-like protein 1
, ly-6/neurotoxin-like protein 1
, secreted Ly-6/uPAR domain-containing protein 2
, secreted Ly-6/uPAR-related protein 2
, secreted Ly6/uPAR related protein 2
, secreted Ly6/uPAR related protein-2