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Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. Additionally we are shipping LCP1 Antibodies (90) and LCP1 Kits (9) and many more products for this protein.
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Human LCP1 Protein expressed in HEK-293 Cells - ABIN2729119
Dubey, Singh, Awasthi, Nagarkoti, Kumar, Ali, Chandra, Kumar, Barthwal, Jagavelu, Sánchez-Gómez, Lamas, Dikshit: L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions. in Free radical biology & medicine 2015
the actin-bundling protein L-plastin (LPL) is required for the perinatal development of alveolar macrophages.
Results identify L-plastin as a key effector of Mst1 (show MST1 Proteins) and establish a novel mechanism linking a signaling intermediate to an actin-binding protein (show PFN1 Proteins) critical to T cell migration.
L-plastin modulates both T- and B-cell function during the germinal center reaction and the production of T-cell-dependent antibody responses.
L-plastin may participate in signaling that enables lymphocyte transmigration
LPL-dependent actin bundling facilitates the formation of lamellipodia and normal immunological synapses and thereby enables T cell activation.
Regulation of sealing ring formation by L-plastin and cortactin (show CTTN Proteins) in osteoclasts.
We thus identify L-plastin as a molecule critical for CCR7 (show CCR7 Proteins)-mediated t-cell motility but dispensable for early CCR7 (show CCR7 Proteins) signaling.
The findings support a mechanism in which miR (show MLXIP Proteins)-375 suppresses RUNX1 (show RUNX1 Proteins) levels, resulting in reduced vimentin (show VIM Proteins) and L-plastin expression. Knockdown of RUNX1 (show RUNX1 Proteins), L-plastin, and vimentin (show VIM Proteins) resulted in significant reductions in cell invasion in vitro, indicating the functional significance of miR (show MLXIP Proteins)-375 regulation of specific proteins involved in head and neck squamous cell carcinoma (HNSCC) invasion.
In this study, the authors found that the actin filament bundling abilities of PLS1 (show PLS1 Proteins) and PLS2 were similarly sensitive to Ca(2 (show CA2 Proteins)+) (pCa50 ~6.4), whereas PLS3 (show PLS3 Proteins) was less sensitive (pCa50 ~5.9).
elevated L-plastin expression promotes elongation and reduces protrusion density in cells with relatively lower L-plastin than fascin (show FSCN1 Proteins) levels.
Enhanced nitroxidative stress may results in LPL S-glutathionylation leading to impaired chemotaxis, polarization, and bactericidal activity of human neutrophils.
association of SNPs in LCP1 and CTIF (show KIAA0427 Proteins) with hearing
An NKX3.1 (show NKX3-1 Proteins) binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer
The proteins (HSP90b (show HSP90AB1 Proteins), TSM1 and L-plastin) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases.
Data suggest that several single-nucleotide polymorphisms (SNPs) of the plastin genes PLS3 (show PLS3 Proteins) and LCP1 could serve as gender- and/or stage-specific molecular predictors of tumor recurrence in stage II/III colorectal cancer as well as therapeutic targets.
L-plastin plays an important role in the clustering of NKG2D (show KLRK1 Proteins) into lipid rafts, and it participates in NKG2D (show KLRK1 Proteins)-mediated inhibition of NK cell chemotaxis.
expression of L-plastin promotes tumor metastasis and, importantly, that this effect depends on an additionally required phosphorylation of L-plastin
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
, leucocyte-specific plastin 1
, 65 kDa macrophage protein
, L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65)
, plastin 2, L
, L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)
, Lymphocyte cytosolic protein-1 (plasmin)
, bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin))
, plastin 2
, epidermal Langerhans cell protein LCP1