Lymphocyte Cytosolic Protein 1 Proteins (LCP1)

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. Additionally we are shipping LCP1 Antibodies (90) and LCP1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat LCP1 LCP1 306071  
LCP1 18826 Q61233
LCP1 3936 P13796
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Top LCP1 Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) REACT_Cytomegalovirus His tag   100 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) REACT_Cytomegalovirus GST tag   100 μg Log in to see 6 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days

LCP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

Top referenced LCP1 Proteins

  1. Human LCP1 Protein expressed in HEK-293 Cells - ABIN2729119 : Dubey, Singh, Awasthi, Nagarkoti, Kumar, Ali, Chandra, Kumar, Barthwal, Jagavelu, Sánchez-Gómez, Lamas, Dikshit: L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions. in Free radical biology & medicine 2015 (PubMed)

More Proteins for Lymphocyte Cytosolic Protein 1 (LCP1) Interaction Partners

Mouse (Murine) Lymphocyte Cytosolic Protein 1 (LCP1) interaction partners

  1. the actin-bundling protein L-plastin (LPL) is required for the perinatal development of alveolar macrophages.

  2. Results identify L-plastin as a key effector of Mst1 (show MST1 Proteins) and establish a novel mechanism linking a signaling intermediate to an actin-binding protein (show PFN1 Proteins) critical to T cell migration.

  3. L-plastin modulates both T- and B-cell function during the germinal center reaction and the production of T-cell-dependent antibody responses.

  4. L-plastin may participate in signaling that enables lymphocyte transmigration

  5. LPL-dependent actin bundling facilitates the formation of lamellipodia and normal immunological synapses and thereby enables T cell activation.

  6. Regulation of sealing ring formation by L-plastin and cortactin (show CTTN Proteins) in osteoclasts.

  7. We thus identify L-plastin as a molecule critical for CCR7 (show CCR7 Proteins)-mediated t-cell motility but dispensable for early CCR7 (show CCR7 Proteins) signaling.

Human Lymphocyte Cytosolic Protein 1 (LCP1) interaction partners

  1. The findings support a mechanism in which miR (show MLXIP Proteins)-375 suppresses RUNX1 (show RUNX1 Proteins) levels, resulting in reduced vimentin (show VIM Proteins) and L-plastin expression. Knockdown of RUNX1 (show RUNX1 Proteins), L-plastin, and vimentin (show VIM Proteins) resulted in significant reductions in cell invasion in vitro, indicating the functional significance of miR (show MLXIP Proteins)-375 regulation of specific proteins involved in head and neck squamous cell carcinoma (HNSCC) invasion.

  2. In this study, the authors found that the actin filament bundling abilities of PLS1 (show PLS1 Proteins) and PLS2 were similarly sensitive to Ca(2 (show CA2 Proteins)+) (pCa50 ~6.4), whereas PLS3 (show PLS3 Proteins) was less sensitive (pCa50 ~5.9).

  3. elevated L-plastin expression promotes elongation and reduces protrusion density in cells with relatively lower L-plastin than fascin (show FSCN1 Proteins) levels.

  4. Enhanced nitroxidative stress may results in LPL S-glutathionylation leading to impaired chemotaxis, polarization, and bactericidal activity of human neutrophils.

  5. association of SNPs in LCP1 and CTIF (show KIAA0427 Proteins) with hearing

  6. An NKX3.1 (show NKX3-1 Proteins) binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer

  7. The proteins (HSP90b (show HSP90AB1 Proteins), TSM1 and L-plastin) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases.

  8. Data suggest that several single-nucleotide polymorphisms (SNPs) of the plastin genes PLS3 (show PLS3 Proteins) and LCP1 could serve as gender- and/or stage-specific molecular predictors of tumor recurrence in stage II/III colorectal cancer as well as therapeutic targets.

  9. L-plastin plays an important role in the clustering of NKG2D (show KLRK1 Proteins) into lipid rafts, and it participates in NKG2D (show KLRK1 Proteins)-mediated inhibition of NK cell chemotaxis.

  10. expression of L-plastin promotes tumor metastasis and, importantly, that this effect depends on an additionally required phosphorylation of L-plastin

LCP1 Protein Profile

Protein Summary

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

Gene names and symbols associated with LCP1

  • lymphocyte cytosolic plastin 1 (lcp1)
  • lymphocyte cytosolic protein 1 (Lcp1)
  • lymphocyte cytosolic protein 1 (L-plastin) (LCP1)
  • lymphocyte cytosolic protein 1 (L-plastin) (lcp1)
  • TOX high mobility group box family member 4 (Tox4)
  • 5730589K01Rik protein
  • A630040M18 protein
  • AA410149 protein
  • AW536232 protein
  • cb245 protein
  • cp64 protein
  • D14Ertd310e protein
  • fj24b12 protein
  • l-plastin protein
  • lc64p protein
  • LCP-1 protein
  • LCP1 protein
  • lpl protein
  • plastin-2 protein
  • pls2 protein
  • pp65 protein
  • wu:fj24b12 protein

Protein level used designations for LCP1

L-plastin , leucocyte-specific plastin 1 , plastin-2 , 65 kDa macrophage protein , L-fimbrin , L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65) , plastin 2, L , L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P) , LCP-1 , Lymphocyte cytosolic protein-1 (plasmin) , bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)) , plastin 2 , epidermal Langerhans cell protein LCP1

30583 Danio rerio
306071 Rattus norvegicus
18826 Mus musculus
3936 Homo sapiens
379911 Xenopus laevis
418852 Gallus gallus
476921 Canis lupus familiaris
540990 Bos taurus
268741 Mus musculus
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