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Lymphocyte Transmembrane Adaptor 1 (LAX1) ELISA Kits

Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells (By similarity). Additionally we are shipping LAX1 Antibodies (65) and LAX1 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human LAX1 LAX1 54900 Q8IWV1
Anti-Mouse LAX1 LAX1 240754 Q8BHB3
Anti-Rat LAX1 LAX1 498232 Q5FVQ5
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More ELISA Kits for LAX1 Interaction Partners

Human Lymphocyte Transmembrane Adaptor 1 (LAX1) interaction partners

  1. TRIM (show TRAT1 ELISA Kits) required LAX for binding to Rab8 (show RAB8A ELISA Kits) in a complex, a novel CTLA-4 (show CTLA4 ELISA Kits)/TRIM (show TRAT1 ELISA Kits)/LAX/Rab8 (show RAB8A ELISA Kits) effector complex in the transport of CTLA-4 (show CTLA4 ELISA Kits) to the surfaces of T cells

  2. We identified the transmembrane domain of LAX as a first motif targeting transmembrane protein constructs to detergent-resistant heavy rafts, a novel type of membrane microdomains containing a number of physiologically important proteins.

  3. Overexpression of LAX in Jurkat cells specifically inhibits T cell receptor-mediated p38 MAPK (show MAPK14 ELISA Kits) activation and NFAT (show NFATC1 ELISA Kits)/AP-1 (show FOSB ELISA Kits) transcriptional activation.

  4. inhibition of signaling events involved in T cell activation by LAX occurs through mechanisms both dependent on and independent of its tyrosine phosphorylation.

Mouse (Murine) Lymphocyte Transmembrane Adaptor 1 (LAX1) interaction partners

  1. SIT and LAX are important negative regulators of immune responses that functionally cooperate.

  2. Upon T or B cell activation (show BLNK ELISA Kits), the LAX protein is up-regulated dramatically. This in vivo study of LAX-deficient mice demonstrates that LAX functions as a negative regulator in lymphocyte signaling.

  3. LAX negatively regulates mast cell function

LAX1 Antigen Profile

Antigen Summary

Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells (By similarity).

Gene names and symbols associated with LAX1

  • lymphocyte transmembrane adaptor 1 (LAX1) antibody
  • lymphocyte transmembrane adaptor 1 (LOC100359066) antibody
  • lymphocyte transmembrane adaptor 1 (Lax1) antibody
  • A530029E09 antibody
  • E430019B13Rik antibody
  • LAX antibody

Protein level used designations for LAX1

lymphocyte transmembrane adaptor 1 , lymphocyte transmembrane adapter 1-like , LAT-like membrane associated protein , linker for activation of x cells , lymphocyte transmembrane adapter 1 , membrane-associated adapter protein LAX , membrane associated adaptor protein LAX , linker for activation of X cells

GENE ID SPECIES
702011 Macaca mulatta
741370 Pan troglodytes
100359066 Oryctolagus cuniculus
100397361 Callithrix jacchus
100437319 Pongo abelii
100589202 Nomascus leucogenys
54900 Homo sapiens
540424 Bos taurus
240754 Mus musculus
498232 Rattus norvegicus
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