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Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. Additionally we are shipping Lymphocyte-Activation Gene 3 Proteins (25) and Lymphocyte-Activation Gene 3 Kits (13) and many more products for this protein.
Showing 10 out of 185 products:
Human Monoclonal LAG3 Primary Antibody for Func, ICC - ABIN1169105
Hannier, Tournier, Bismuth, Triebel: CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling. in Journal of immunology (Baltimore, Md. : 1950) 1998
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Mouse (Murine) Monoclonal LAG3 Primary Antibody for FACS - ABIN2660045
Baixeras, Huard, Miossec, Jitsukawa, Martin, Hercend, Auffray, Triebel, Piatier-Tonneau: Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. in The Journal of experimental medicine 1992
Show all 5 references for ABIN2660045
Mouse (Murine) Monoclonal LAG3 Primary Antibody for ELISA (Capture) - ABIN2658538
Workman, Rice, Dugger, Kurschner, Vignali: Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). in European journal of immunology 2002
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Human Monoclonal LAG3 Primary Antibody for Func, ICC - ABIN1169112
Huard, Gaulard, Faure, Hercend, Triebel: Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand. in Immunogenetics 1994
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Mouse (Murine) Monoclonal LAG3 Primary Antibody for FACS - ABIN120324
Workman, Vignali: Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). in Journal of immunology (Baltimore, Md. : 1950) 2005
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We show that the expression of LAG3 is highly induced in the lungs and particularly in the granulomatous lesions of macaques experimentally infected with mycobacterium tuberculosis.
LAG3 and PD1 (show PDCD1 Antibodies) co-inhibitory molecules have roles in collaborating to limit CD8 (show CD8A Antibodies)+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
Poxvirus-Based Active Immunotherapy with PD-1 (show PDCD1 Antibodies) and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice.
Lymphatic endothelial cells (LECs) serve as an antigen reservoir for CD4 (show CD4 Antibodies) T-cell tolerance, and MHC-II molecules on LECs are used to induce CD8 (show CD8A Antibodies) T-cell tolerance via LAG-3.
LAG-3 expression on Tconv cells makes them more susceptible to Treg based suppression, and also regulates the development of a TH1 (show HAND1 Antibodies) T-cell response.
LAG-3 exerts an important regulatory effect on autoimmunity.
Lag-3 is an important regulatory molecule involved in alloreactive T cell proliferation and activation after bone marrow transplantation.
these results define a strong synergy between the PD-1 (show PDCD1 Antibodies) and LAG-3 inhibitory pathways in tolerance to both self and tumor antigens.
We conclude that LAG-3 is necessary for regulating CD4 (show CD4 Antibodies)(+) and CD8 (show CD8A Antibodies)(+) T cell function during autoimmune diabetes
LAG-3 is required for long-term peripheral CD8 (show CD8A Antibodies) but not CD4 (show CD4 Antibodies) T-cell tolerance and this requirement is CD8 (show CD8A Antibodies) cell-extrinsic.
LAG-3 acts synergistically with PD-1 (show PDCD1 Antibodies) and/or other immunoregulatory genes to prevent autoimmunity in mice.
Data indicate that in recurrent spontaneous abortion patients, the expression levels of CD49b (show ITGA2 Antibodies) and LAG-3 (CD223) on CD14 (show NDUFA2 Antibodies)(+) mononuclear cells and the plasma level of transforming growth factor beta (TGF-beta) decreased obviously compared with normal females.
iNKT cytokine production is profoundly altered by both HIV infection and treatment, and LAG-3, but not PD-1 (show PDCD1 Antibodies), expression is associated with a reduction in iNKT IFNgamma production.
NFKB1 (show NFKB1 Antibodies), CD27 (show CD27 Antibodies), LAG3 and IKZF3 (show IKZF3 Antibodies) are new susceptibility genes for psoriasis.
The elevated expression of LAG-3 at the genital tract suggests it may regulate T-cell activation, and identify cells susceptible to HIV infection. The enrichment of LAG-3 on double negative T cells suggests LAG-3 may contribute to the immunoregulatory activity of these cells.
the LAG-3/MHC class II (show HLA-DPA1 Antibodies) pathway may synergize with PD-1 (show PDCD1 Antibodies)/PD ligand to enhance T cell-mediated immune responses.
LAG-3 trafficking from lysosomal compartments to the cell surface is dependent on the cytoplasmic domain through protein kinase C (show PKC Antibodies) signaling in activated T cells.
These results suggest that LAG-3-mediated activation of plasmacytoid dendritic cells takes place in vivo at tumor sites, and it is in part responsible for directing an immune-suppressive environment.
Expression of LAG-3 is coincident with the impaired effector function of HBV-specific CD8 (show CD8A Antibodies)(+) T cell in HCC (show FAM126A Antibodies) patients.
our data suggest that the LAG-3-MHC II interaction could be viewed as a bidirectional immune escape pathway in melanoma
Multiple myeloma was associated with 2 SNPs in intron regions of LAG3 within 20 k base pairs 5' upstream of the candidate CD4 (show CD4 Antibodies) gene. The variant in LAG3 gene itself may play a role in susceptibility of MM.
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.
lymphocyte-activation gene 3
, lymphocyte-activation protein 3
, lymphocyte-activation protein 3-like
, lymphocyte activation gene 3 protein-like
, lymphocyte activation gene 3 protein
, lymphocyte activation gene 3