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Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. Additionally we are shipping Lymphocyte-Activation Gene 3 Antibodies (212) and Lymphocyte-Activation Gene 3 Proteins (28) and many more products for this protein.
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We show that the expression of LAG3 is highly induced in the lungs and particularly in the granulomatous lesions of macaques experimentally infected with mycobacterium tuberculosis.
Study suggests that expression of the inhibitory receptors PD-1 (show PDCD1 ELISA Kits) and LAG-3 on CD4 (show CD4 ELISA Kits)(+) T cells and their reduced IL-2 (show IL2 ELISA Kits) production are common characteristic features of Plasmodium infection.
An IL-27 (show IL27 ELISA Kits)/Lag3 axis enhances Foxp3 (show FOXP3 ELISA Kits)+ regulatory T cell-suppressive function and therapeutic efficacy.
LAG3 and PD1 (show PDCD1 ELISA Kits) co-inhibitory molecules have roles in collaborating to limit CD8 (show CD8A ELISA Kits)+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
Poxvirus-Based Active Immunotherapy with PD-1 (show PDCD1 ELISA Kits) and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice.
Lymphatic endothelial cells (LECs) serve as an antigen reservoir for CD4 (show CD4 ELISA Kits) T-cell tolerance, and MHC-II molecules on LECs are used to induce CD8 (show CD8A ELISA Kits) T-cell tolerance via LAG-3.
LAG-3 expression on Tconv cells makes them more susceptible to Treg based suppression, and also regulates the development of a TH1 (show HAND1 ELISA Kits) T-cell response.
LAG-3 exerts an important regulatory effect on autoimmunity.
Lag-3 is an important regulatory molecule involved in alloreactive T cell proliferation and activation after bone marrow transplantation.
these results define a strong synergy between the PD-1 (show PDCD1 ELISA Kits) and LAG-3 inhibitory pathways in tolerance to both self and tumor antigens.
We conclude that LAG-3 is necessary for regulating CD4 (show CD4 ELISA Kits)(+) and CD8 (show CD8A ELISA Kits)(+) T cell function during autoimmune diabetes
LAG-3 is highly expressed in peripheral blood CD8 (show CD8A ELISA Kits)+ T cells in chronic HBV-infected patients.
Data indicate that in recurrent spontaneous abortion patients, the expression levels of CD49b (show ITGA2 ELISA Kits) and LAG-3 (CD223) on CD14 (show NDUFA2 ELISA Kits)(+) mononuclear cells and the plasma level of transforming growth factor beta (TGF-beta) decreased obviously compared with normal females.
iNKT cytokine production is profoundly altered by both HIV infection and treatment, and LAG-3, but not PD-1 (show PDCD1 ELISA Kits), expression is associated with a reduction in iNKT IFNgamma production.
NFKB1 (show NFKB1 ELISA Kits), CD27 (show CD27 ELISA Kits), LAG3 and IKZF3 (show IKZF3 ELISA Kits) are new susceptibility genes for psoriasis.
The elevated expression of LAG-3 at the genital tract suggests it may regulate T-cell activation, and identify cells susceptible to HIV infection. The enrichment of LAG-3 on double negative T cells suggests LAG-3 may contribute to the immunoregulatory activity of these cells.
the LAG-3/MHC class II (show HLA-DPA1 ELISA Kits) pathway may synergize with PD-1 (show PDCD1 ELISA Kits)/PD ligand to enhance T cell-mediated immune responses.
LAG-3 trafficking from lysosomal compartments to the cell surface is dependent on the cytoplasmic domain through protein kinase C (show PKC ELISA Kits) signaling in activated T cells.
These results suggest that LAG-3-mediated activation of plasmacytoid dendritic cells takes place in vivo at tumor sites, and it is in part responsible for directing an immune-suppressive environment.
Expression of LAG-3 is coincident with the impaired effector function of HBV-specific CD8 (show CD8A ELISA Kits)(+) T cell in HCC (show FAM126A ELISA Kits) patients.
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.
lymphocyte-activation gene 3
, lymphocyte-activation protein 3
, lymphocyte-activation protein 3-like
, lymphocyte activation gene 3 protein-like
, lymphocyte activation gene 3 protein
, lymphocyte activation gene 3