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LSP1 encodes an intracellular F-actin binding protein. Additionally we are shipping LSP1 Proteins (7) and LSP1 Kits (3) and many more products for this protein.
Showing 10 out of 186 products:
Human Monoclonal LSP1 Primary Antibody for IF, IP - ABIN968145
Howard, Li, Torres, Guerrero, Coates: The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein. in Blood 1994
Show all 5 references for ABIN968145
Human Polyclonal LSP1 Primary Antibody for ELISA, WB - ABIN4331782
Liu, Cara, Kaur, Raharjo, Mullaly, Jongstra-Bilen, Jongstra, Kubes: LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration. in The Journal of experimental medicine 2005
Show all 2 references for ABIN4331782
Human Polyclonal LSP1 Primary Antibody for ELISA, WB - ABIN4331781
Gringhuis, den Dunnen, Litjens, van der Vlist, Geijtenbeek: Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. in Nature immunology 2009
Show all 2 references for ABIN4331781
Human Polyclonal LSP1 Primary Antibody for IHC, IHC (p) - ABIN4331785
Johansson, Tabor, Wikell, Jalkanen, Fuxe: TGF-β1-Induced Epithelial-Mesenchymal Transition Promotes Monocyte/Macrophage Properties in Breast Cancer Cells. in Frontiers in oncology 2015
Human Polyclonal LSP1 Primary Antibody for FACS, IHC (p) - ABIN651634
Odefrey, Stone, Gurrin, Byrnes, Apicella, Dite, Cawson, Giles, Treloar, English, Hopper, Southey,: Common genetic variants associated with breast cancer and mammographic density measures that predict disease. in Cancer research 2010
the LSP1-myosin1e bimolecular complex plays a pivotal role in the regulation of actin cytoskeleton remodeling during Fc gamma receptor (show FCGR1A Antibodies)-driven phagocytosis.
the importance of LSP1 Copy number variations and LSP1 insufficiency in the pathogenesis of rheumatoid arthritis, is reported.
Data indicate that in lymphocyte specific 1 protein (LSP1)-deficient mice, PECAM-1 (show PECAM1 Antibodies) expression was reduced in endothelial cells, but not in neutrophils.
TRAF1 (show TRAF1 Antibodies) and LSP1 cooperate downstream of 4-1BB (show TNFRSF9 Antibodies) to activate ERK (show EPHB2 Antibodies) signaling and down-modulate the levels of Bim (show BCL2L11 Antibodies) leading to enhanced T cell survival.
Endothelial LSP1 participates in leukocyte adhesion in vitro, and leukocyte adhesion, through ICAM-1 (show ICAM1 Antibodies), fosters the activation of endothelial LSP1.
LSP1 plays an important role in leukocyte recruitment induced by both KC and MIP-2 (show CXCL2 Antibodies).
Data demonstrate that endothelial LSP1 is recruited to the cytoskeleton in inflammation and plays an important role in forming endothelial domes thereby regulating neutrophil transendothelial migration.
Lsp1 negatively regulates fMLP (show FPR1 Antibodies)-induced polarization and chemotaxis of neutrophils during inflammation through its function on adhesion via specific integrins, such as Mac-1 (CD11b/CD18 (show ITGAM Antibodies)).
The results show a complex function of LSP1 in regulating leukocyte recruitment to inflamed sites.
MK2-regulated LSP1 phosphorylation is involved in stabilization of F-actin polarization during neutrophil chemotaxis.
Underexpression of LSP1 is associated with Breast Cancer Recurrence.
LSP1 rs569550 and rs592373 polymorphisms are both risk factors for breast cancer.
The breast cancer SNP LSP1 rs3817198 was associated with an increased risk of lung cancer (odds ratio: 1.10) This association was strongest for women with adenocarcinoma (P = 1.2x10(-4)).
Data indicate that slit2N alters the localization and binding of Robo1 (show ROBO1 Antibodies) to WASp (show WASL Antibodies) and LSP1 in HIV-1-gp120 (show ITIH4 Antibodies)-treated immature dendritic cells (iDCs).
Single nucleotide polymorphism in LSP1 is associated with breast cancer.
The LSP1 rs3817198T>C polymorphism is a low-penetrant risk factor for developing breast cancer but may not be in Africans.
Low-risk variants of LSP1 is associated with familial breast cancer.
The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 (show BRCA2 Antibodies) mutation carriers.
LSP1 interacts with F-actin and the cytoskeleton through residues downstream of amino acid residue 230. The cytoskeleton binding site of mouse LSP1 maps to the 300-330 interval.
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.
lymphocyte-specific protein 1
, lymphocyte-specific protein 1, isoform 3
, 52 kDa phosphoprotein
, S37 protein
, leukocyte specific protein 1
, leukocyte-specific protein 1
, lymphocyte-specific antigen WP34
, 47 kDa actin binding protein
, 47 kDa actin-binding protein
, F-actin binding and cytoskeleton associated protein
, leufactin (leukocyte F-actin binding protein)
, 1 BAC CH230-300K22 (Children's Hospital Oakland Research Institute) complete
, lymphocyte specific 1