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KDM2A encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping Lysine (K)-Specific Demethylase 2A Antibodies (55) and Lysine (K)-Specific Demethylase 2A Proteins (3) and many more products for this protein.
In this study, KDM2A was identified as a novel substrate of ATM (show ATM ELISA Kits). DSB enhanced the interaction between ATM (show ATM ELISA Kits) and KDM2A, which induced ATM (show ATM ELISA Kits)-mediated phosphorylation of KDM2A at T632.
The results suggest that under mild glucose starvation AMP (show APRT ELISA Kits)-activated kinase induces KDM2A-dependent reduction of rRNA transcription to control cell proliferation.
FBXL11 is proposed as a novel component of the circadian clock that regulates the circadian gene expression by a so far unknown mechanism.
The protein lysine demethylases Kdm2a and Kdm2b (show KDM2B ELISA Kits) regulate the turnover of non-phosphorylated beta-catenin (show CTNNB1 ELISA Kits) specifically within the nucleus via direct interaction with the fourth and fifth armadillo (show PKP1 ELISA Kits) repeats.
Upregulation of KDM2A is very important in the progression of gastric cancer.
a regulatory role for KDM2A in breast cancer cell invasion and migration, through the regulation of E2F1 (show E2F1 ELISA Kits) function
KDM2A binds to the rDNA promoter with unmethylated CpG sequences via the CxxC-ZF domain
KDM2A represses histone deacetylase 3 (show HDAC3 ELISA Kits) and has a role in tumorigenicity of lung cancer cells
KDMA2 is frequently overexpressed in NSCLC tumors & cell lines. It is needed for in vitro proliferation & invasion. KDM2A activated ERK1/2 (show MAPK1/3 ELISA Kits) by epigenetic repression of DUSP3 (show DUSP3 ELISA Kits) expression via demethylation of dimethylated H3K36 at the DUSP3 (show DUSP3 ELISA Kits) locus.
KDM2A is a H3K4 demethylase (show MBD2 ELISA Kits) that regulates cell proliferation through p15(INK4B (show CDKN2B ELISA Kits)) and p27(Kip1 (show CDKN1B ELISA Kits)) in stem cells from apical papilla.
JHDM1A is differentially expressed in porcine embryonic skeletal muscle and associated with meat growth and quality traits.
Fbxl11 plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival.
we identify Jhdm1a negatively regulates gluconeogenic gene PEPCK (show PEPCK ELISA Kits) and G6Pase (show G6PC ELISA Kits) expression both in vitro and in vivo
Data describe a NF-kappaB (show NFKB1 ELISA Kits) regulatory pathway that is driven by reversible lysine methylation of p65 (show NFkBP65 ELISA Kits), carried out by nuclear receptor-binding SET domain-containing protein 1 (NSD1 (show NSD1 ELISA Kits)) and F-box and leucine-rich repeat protein 11 (FBXL11).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.
F-box and leucine-rich repeat protein 11
, CXXC-type zinc finger protein 8
, F-box/LRR-repeat protein 11
, [Histone-H3]-lysine-36 demethylase 1A
, jmjC domain-containing histone demethylation protein 1A
, jumonji C domain-containing histone demethylase 1A
, lysine-specific demethylase 2A
, lysine (K)-specific demethylase 2A
, F-box protein containing leucine repeats