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Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Additionally we are shipping KDM3B Antibodies (99) and many more products for this protein.
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findings indicate that Kdm3b is required for normal spermatogenesis and sexual behaviors in male mice
These results demonstrate that Kdm3b-mediated H3K9 demethylation plays essential roles in maintenance of the circulating IGF-1 (show IGF1 Proteins), postnatal somatic growth, circulating 17beta-estradiol, and female reproductive function.
H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1 (show ANGPT1 Proteins).
High expression of KDM3B and KDM5A (show KDM5A Proteins) is associated with a better prognosis (no recurrence after mastectomy p=0.005 and response to docetaxel p=0.005)in breast cancer patients.
evidence that the H3K9-me1 (show ME1 Proteins)/2 demethylase KDM3B might play a role in leukemogenesis via activation of lmo2 (show LMO2 Proteins) through interdependent actions with the histone acetyltransferase complex containing CBP (show CREBBP Proteins)
A novel nuclear protein (show RDBP Proteins), 5qNCA is a candidate for the myeloid leukemia (show BCL11A Proteins) tumor suppressor gene on chromosome 5 band q31.
Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
lysine (K)-specific demethylase 3B
, jumonji domain containing 1B
, lysine-specific demethylase 3B-like
, jmjC domain-containing histone demethylation protein 2B
, jumonji domain-containing protein 1B
, lysine-specific demethylase 3B
, nuclear protein 5qNCA