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Lysine (K)-Specific Demethylase 4A Proteins (KDM4A)

KDM4A is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. Additionally we are shipping KDM4A Antibodies (78) and KDM4A Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KDM4A 9682 O75164
KDM4A 230674 Q8BW72
Rat KDM4A KDM4A 313539  
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Top KDM4A Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Baculovirus Human DYKDDDDK Tag JMJD2A / KDM4A activity assay. Recombinant JMJD2A / KDM4A activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant JMJD2A / KDM4A protein gel. JMJD2A / KDM4A protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$460.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

KDM4A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Lysine (K)-Specific Demethylase 4A (KDM4A) Interaction Partners

Human Lysine (K)-Specific Demethylase 4A (KDM4A) interaction partners

  1. Study demonstrates that JMJD2A contributes to tumorigenesis in non-small cell lung cancer (NSCLC) by regulating miR (show MLXIP Proteins)-150. Additionally, JMJD2A overexpression is associated with a poor prognosis for NSCLC patients.

  2. High KDM4A expression is associated with endometrial cancer progression.

  3. Studies indicate that histone lysine demethylase (JmjC-KDM) KDM4A protein has been implicated in numerous cancers and cardiovascular diseases.

  4. KDM4A is regulated by hsa (show CD24 Proteins)-mir (show MLXIP Proteins)-23a-3p, hsa (show CD24 Proteins)-mir (show MLXIP Proteins)-23b-3p, and hsa (show CD24 Proteins)-mir (show MLXIP Proteins)-137.

  5. these data reveal a JMJD2A/ETV1 (show ETV1 Proteins)/YAP1 (show YAP1 Proteins) axis that promotes prostate cancer initiation and that may be a suitable target for therapeutic inhibition.

  6. Results indicate that SCF (show KITLG Proteins)(Fbxo22 (show FBXO22 Proteins))-KDM4A is an E3 ubiquitin ligase (show MUL1 Proteins) that targets methylated p53 (show TP53 Proteins) and regulates key senescent processes.

  7. This study showed that KDM4A interacts with RNA Polymerase I (show POLR1C Proteins), associates with active ribosomal RNA genes and is required for serum-induced activation of rDNA transcription.

  8. Jra recruits the HP1a (show TFF1 Proteins)/KDM4A complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation

  9. A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR (show FRAP1 Proteins) inhibitors

  10. this review focuses on describing the structure, mechanisms, and function of KDM4A and primarily discusses the role of KDM4A in cancer development and the importance of KDM4A as a potential therapeutic target. [review]

Mouse (Murine) Lysine (K)-Specific Demethylase 4A (KDM4A) interaction partners

  1. these data reveal a JMJD2A/ETV1 (show ETV1 Proteins)/YAP1 (show YAP1 Proteins) axis that promotes prostate cancer initiation and that may be a suitable target for therapeutic inhibition.

  2. Results indicate that SCF (show KITLG Proteins)(Fbxo22 (show FBXO22 Proteins))-KDM4A is an E3 ubiquitin ligase (show MUL1 Proteins) that targets methylated p53 (show TP53 Proteins) and regulates key senescent processes.

  3. These findings together demonstrate the essential role of KDM4A and KDM4C (show KDM4C Proteins) in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 (show KDR Proteins) and VE-cadherin (show CDH5 Proteins) promoters, respectively

  4. As well as three novel motifs in JMJD2A-regulated genes.

  5. JMJD2A bound to the FHL1 (show FHL1 Proteins) promoter in response to TAC (show IL2RA Proteins), upregulated FHL1 (show FHL1 Proteins) expression, and downregulated H3K9 trimethylation. JMJD2A promotes cardiac hypertrophy under pathological conditions by a novel mechanism.

  6. JHDM3A(GFP)(701) is a suitable catalytic module that can be targeted, under the control of a guide protein, to specific loci where the chromatin H3K9me3 status and the milieu of gene expression are to be modified.

Cow (Bovine) Lysine (K)-Specific Demethylase 4A (KDM4A) interaction partners

  1. Histone demethylases KDM3A (show KDM3A Proteins), KDM4A, and KDM4C (show KDM4C Proteins) were expressed before and after embryonic genome activation, whereas KDM5B (show KDM5B Proteins) was mainly expressed during the blastocyst period.

KDM4A Protein Profile

Protein Summary

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.

Gene names and symbols associated with KDM4A

  • jumonji domain containing 2A (JMJD2A)
  • lysine (K)-specific demethylase 4A (KDM4A)
  • jumonji domain containing 2A (LOC100353935)
  • lysine (K)-specific demethylase 4A (Kdm4a)
  • D4Ertd222e protein
  • JHDM3A protein
  • Jmjd2 protein
  • Jmjd2a protein
  • mKIAA0677 protein
  • TDRD14A protein

Protein level used designations for KDM4A

jumonji domain containing 2A , lysine (K)-specific demethylase 4A , lysine-specific demethylase 4A , jumonji domain-containing protein 2A , JmjC domain-containing histone demethylation protein 3A , jumonji domain-containing 2A , lysine-specific demethylase 4A-like , jmjC domain-containing histone demethylation protein 3A , jumonji C domain-containing histone demethylase 3A , jumonji domain containing 2 , tudor domain containing 14A

GENE ID SPECIES
424571 Gallus gallus
456829 Pan troglodytes
701272 Macaca mulatta
100172003 Pongo abelii
100353935 Oryctolagus cuniculus
100228023 Taeniopygia guttata
100294710 Sus scrofa
100473204 Ailuropoda melanoleuca
100544296 Meleagris gallopavo
9682 Homo sapiens
230674 Mus musculus
313539 Rattus norvegicus
482530 Canis lupus familiaris
512622 Bos taurus
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