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Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Additionally we are shipping KDM5B Proteins (4) and many more products for this protein.
Showing 10 out of 73 products:
Human Monoclonal KDM5B Primary Antibody for WB - ABIN395143
Roesch, Fukunaga-Kalabis, Schmidt, Zabierowski, Brafford, Vultur, Basu, Gimotty, Vogt, Herlyn: A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. in Cell 2010
Show all 7 references for ABIN395143
Mouse (Murine) Polyclonal KDM5B Primary Antibody for WB - ABIN658397
Kim, Shin, Subramaniam, Bruinsma, Kim, Hawse, Spelsberg, Janknecht: Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. in Biochemical and biophysical research communications 2010
Show all 5 references for ABIN658397
Human Monoclonal KDM5B Primary Antibody for IF, IHC (p) - ABIN1327126
Xiang, Zhu, Han, Ye, Xu, Peng, Ma, Yu, Lin, Chen, Chen: JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 3 references for ABIN1327126
Human Monoclonal KDM5B Primary Antibody for ELISA, WB - ABIN524186
Hayami, Yoshimatsu, Veerakumarasivam, Unoki, Iwai, Tsunoda, Field, Kelly, Neal, Yamaue, Ponder, Nakamura, Hamamoto: Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. in Molecular cancer 2010
Hsa-miR-448 disrupting KDM5B-MALAT1 signalling axis and associated activities in TNBC cells, projects it as a putative therapeutic factor for selective eradication of TNBC cells.
data indicate that parallel immunohistochemical assays of the expression levels of all the isoforms and of the RBP2-H1 variant of JARID1B may be an efficient technique of differentiating between benign naevi and melanomas
KDM5B, a histone demethylase (show MBD2 Antibodies) known to be involved in breast cancer tumorigenesis, as a target of miR (show MLXIP Antibodies)-137.
Data show that KDM5B is frequently up-regulated in hepatocellular carcinoma tissues and cell lines and correlated with poor prognosis. Its depletion leads to highly impaired clonogenesis and cell cycle arrest through up-regulation of p15 (show CDKN2B Antibodies) and p27 (show PAK2 Antibodies).
the presented data suggest a mechanism through which Ikaros (show IKZF1 Antibodies) and HDAC1 (show HDAC1 Antibodies) regulate the epigenetic signature in leukemia: via regulation of JARID1B transcription.
Characterization of a Linked Jumonji (show JARID2 Antibodies) Domain of the KDM5/JARID1 Family of Histone H3 (show HIST3H3 Antibodies) Lysine 4 Demethylases.
The data demonstrated that protein expression of p16 (show CDKN2A Antibodies) and JARID1B/KDM5B is negatively correlated in invasive ductal carcinoma of the breast.
provided evidence that JARID1B via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB
Our results, for the first time, portray a pivotal role of JARID1B in stimulating metastatic behaviors of hepatocellular carcinoma cells
Our results collectively suggested that JARID1B expressed in lung cancer played a role in lung cancer cells proliferation and invasion, which may be partly associated with the p53 (show TP53 Antibodies) expression
data suggest Kdm5b negatively regulates neurogenesis and represses reelin (show RELN Antibodies) in neural stem cells from the adult subventricular zone.
These results suggest that KDM5B acts to repress type I IFN and other innate cytokines to promote an altered immune response following Respiratory syncytial virus infection that contributes to development of chronic disease.
findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR
Deletion of Jarid1b compromises hematopoietic stem cell (HSC (show FUT1 Antibodies)) self-renewal capacity; Jarid1b is a positive regulator of HSC (show FUT1 Antibodies) potential.
Mechanistically, JARID1B was required for GATA3 (show GATA3 Antibodies) recruitment to the Foxa1 (show FOXA1 Antibodies) promoter to activate Foxa1 (show FOXA1 Antibodies) expression.
KDM5B is a barrier to the reprogramming process as evidenced by the accelerated reprogramming of differentiated cells in the absence of Kdm5b.
these studies identified Jarid1b as a negative regulator of hematopoietic stem cell (HSC (show FUT1 Antibodies)) activity and Jhdmlf as a positive regulator of HSC (show FUT1 Antibodies) activity.
Results suggest a role for Jarid1b in Rb-mediated repression of cell cycle genes during senescence.
results delineate an essential role for Jarid1b-mediated transcriptional control during embryonic stem cell differentiation
The present study demonstrated a functional contribution of PLU1 overexpression with concomitant epigenetic dysregulation in cancer progression.
KDM5B is required for porcine embryo development through regulating the balance of bivalent H3K4me3-H3K27me3 modifications.
Histone demethylases KDM3A (show KDM3A Antibodies), KDM4A (show KDM4A Antibodies), and KDM4C (show KDM4C Antibodies) were expressed before and after embryonic genome activation, whereas KDM5B was mainly expressed during the blastocyst period.
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor (By similarity).
jumonji, AT rich interactive domain 1B (Rbp2 like)
, jumonji, AT rich interactive domain 1Ba (Rbp2 like)
, histone demethylase JARID1B-B
, jumonji/ARID domain-containing protein 1B-B
, lysine-specific demethylase 5B-B
, putative DNA/chromatin binding motif
, lysine (K)-specific demethylase 5B
, Jumonji, AT rich interactive domain 1B (RBP2-like)
, jumonji, AT rich interactive domain 1B
, lysine-specific demethylase 5B-like
, cancer/testis antigen 31
, histone demethylase JARID1B
, jumonji/ARID domain-containing protein 1B
, lysine-specific demethylase 5B
, retinoblastoma-binding protein 2 homolog 1
, retinoblastoma-binding protein 2, homolog 1A
, putative DNA/chromatin binding motif 1