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Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Additionally we are shipping and Kdm6b Kits (1) and many more products for this protein.
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Human Polyclonal Kdm6b Primary Antibody for IF, IHC (p) - ABIN387862
Lu, Lu, Liao, Yu, Chung, Kao, Wu: Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. in The Journal of biological chemistry 2010
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Mouse (Murine) Polyclonal Kdm6b Primary Antibody for IHC (p), WB - ABIN387863
Das, Jung, Chai: The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells. in PLoS ONE 2010
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Human Polyclonal Kdm6b Primary Antibody for EIA, IF - ABIN1450111
De Santa, Totaro, Prosperini, Notarbartolo, Testa, Natoli: The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. in Cell 2007
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Human Polyclonal Kdm6b Primary Antibody for WB - ABIN387864
Shaw, Martin: Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. in EMBO reports 2009
Dog (Canine) Polyclonal Kdm6b Primary Antibody for WB - ABIN2778610
Hong, Cho, Yu, Yu, Veenstra, Ge: Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. in Proceedings of the National Academy of Sciences of the United States of America 2007
Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal (show CAD Antibodies) fin regeneration, and that Kdm6b.1 may be the histone demethylase (show MBD2 Antibodies) required during regeneration.
JMJD3 up-regulation and NF-kappaB (show NFKB1 Antibodies) activation occur in the region of the wound edge during keratinocyte wound healing
these studies established a critical role of Jmjd3-mediated H3K27 demethylation in Th17 cell differentiation and suggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses.
These results strongly demonstrated that JMJD3 is required for osteoblast differentiation and bone formation in mice.
APN (show ANPEP Antibodies) can help to reduce periodontitis-related bone loss, modulate JMJD3 and IRF4 (show IRF4 Antibodies) expression, and macrophage infiltration.
JMJD3 is an epigenetic regulator in development and disease. (Review)
Jmjd3 is required for T-cell development.
Jmjd3-catalyzed erasure of H3K27me3 is required for brown fat gene expression and browning of white fat.
Utx (show KDM6A Antibodies) and Jmjd3 mutant mouse embryonic fibroblasts (MEFs) demonstrate dramatic loss of H3K27me3 from promoters of several Hox (show MSH2 Antibodies) genes and transcription factors.
Jmjd3 is an epigenetic factor in T-cell differentiation via changes in histone methylation and target gene expression.
JMJD3 is a key epigenetic regulator in the process of cartilage maturation during endochondral bone formation.
Low JMJD3 expression is associated with Colorectal Cancer.
JMJD3 promotes SAHF formation by demethylating RB at K810, which reduce the level of phosphorylation of RB protein at S807/811, and this interplay promotes the formation of senescence-associated heterochromatin foci in senescent WI38 cells.
We demonstrate that KDM6B plays a key role in clear cell renal cell carcinoma (show MOK Antibodies)
Jmjd3 regulates osteoblast apoptosis through targeting Bcl-2 (show BCL2 Antibodies) expression and Bim (show BCL2L11 Antibodies) phosphorylation.
Findings reveal a novel epigenetic mechanism by which JMJD3 promotes melanoma progression and metastasis.
KDM6B may act in a pro-apoptotic role in NSCLC.
Demethylation of IGFBP5 (show IGFBP5 Antibodies) by Histone Demethylase (show MBD2 Antibodies) KDM6B Promotes Mesenchymal Stem Cell-Mediated Periodontal Tissue Regeneration by Enhancing Osteogenic Differentiation and Anti-Inflammation Potentials.
Data indicate a reverse correlation between the mRNA levels of histone H3 (show HIST3H3 Antibodies) lysine-27 demethylase (show MBD2 Antibodies) (JMJD3) and global histone h3 (show HIST3H3 Antibodies) lysine 27 methylation (H3K27me3).
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
jumonji domain containing 3
, lysine (K)-specific demethylase 6B
, jumonji domain containing 3, histone lysine demethylase
, lysine-specific demethylase 6B-like
, jmjC domain-containing protein 3
, jumonji domain-containing protein 3
, lysine-specific demethylase 6B
, lysine demethylase 6B
, jumonji domain-containing 3