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Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Additionally we are shipping Kdm6b Antibodies (90) and and many more products for this protein.
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Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal (show CAD ELISA Kits) fin regeneration, and that Kdm6b.1 may be the histone demethylase (show MBD2 ELISA Kits) required during regeneration.
JMJD3 up-regulation and NF-kappaB (show NFKB1 ELISA Kits) activation occur in the region of the wound edge during keratinocyte wound healing
these studies established a critical role of Jmjd3-mediated H3K27 demethylation in Th17 cell differentiation and suggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses.
These results strongly demonstrated that JMJD3 is required for osteoblast differentiation and bone formation in mice.
APN (show ANPEP ELISA Kits) can help to reduce periodontitis-related bone loss, modulate JMJD3 and IRF4 (show IRF4 ELISA Kits) expression, and macrophage infiltration.
JMJD3 is an epigenetic regulator in development and disease. (Review)
Jmjd3 is required for T-cell development.
Jmjd3-catalyzed erasure of H3K27me3 is required for brown fat gene expression and browning of white fat.
Utx (show KDM6A ELISA Kits) and Jmjd3 mutant mouse embryonic fibroblasts (MEFs) demonstrate dramatic loss of H3K27me3 from promoters of several Hox (show MSH2 ELISA Kits) genes and transcription factors.
Jmjd3 is an epigenetic factor in T-cell differentiation via changes in histone methylation and target gene expression.
JMJD3 is a key epigenetic regulator in the process of cartilage maturation during endochondral bone formation.
JMJD3 promotes SAHF formation by demethylating RB at K810, which reduce the level of phosphorylation of RB protein at S807/811, and this interplay promotes the formation of senescence-associated heterochromatin foci in senescent WI38 cells.
We demonstrate that KDM6B plays a key role in clear cell renal cell carcinoma
Jmjd3 regulates osteoblast apoptosis through targeting Bcl-2 (show BCL2 ELISA Kits) expression and Bim (show BCL2L11 ELISA Kits) phosphorylation.
Findings reveal a novel epigenetic mechanism by which JMJD3 promotes melanoma progression and metastasis.
KDM6B may act in a pro-apoptotic role in NSCLC.
Demethylation of IGFBP5 (show IGFBP5 ELISA Kits) by Histone Demethylase (show MBD2 ELISA Kits) KDM6B Promotes Mesenchymal Stem Cell-Mediated Periodontal Tissue Regeneration by Enhancing Osteogenic Differentiation and Anti-Inflammation Potentials.
Data indicate a reverse correlation between the mRNA levels of histone H3 (show HIST3H3 ELISA Kits) lysine-27 demethylase (show MBD2 ELISA Kits) (JMJD3) and global histone h3 (show HIST3H3 ELISA Kits) lysine 27 methylation (H3K27me3).
Results show that JMJD3 protein is overexpressed in high-grade glioma cells and correlated with dysfunctional activation of senescence-related processes, including proinflammatory cytokines and stem cell tropism toward tumors.
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
jumonji domain containing 3
, lysine (K)-specific demethylase 6B
, jumonji domain containing 3, histone lysine demethylase
, lysine-specific demethylase 6B-like
, jmjC domain-containing protein 3
, jumonji domain-containing protein 3
, lysine-specific demethylase 6B
, lysine demethylase 6B
, jumonji domain-containing 3