Lysine (K)-Specific Demethylase 4A Proteins (KDM4A)

KDM4A is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. Additionally we are shipping KDM4A Antibodies (119) and KDM4A Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KDM4A 9682 O75164
KDM4A 230674 Q8BW72
Rat KDM4A KDM4A 313539  
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Top KDM4A Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 2 to 3 Days
$378.00
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Baculovirus Human DYKDDDDK Tag JMJD2A / KDM4A activity assay. Recombinant JMJD2A / KDM4A activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant JMJD2A / KDM4A protein gel. JMJD2A / KDM4A protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$466.67
Details
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$656.00
Details

KDM4A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , , ,
Mouse (Murine)

More Proteins for Lysine (K)-Specific Demethylase 4A (KDM4A) Interaction Partners

Human Lysine (K)-Specific Demethylase 4A (KDM4A) interaction partners

  1. results suggest that KDM4A possesses the potential to act as an oxygen sensor in the context of chromatin modifications, with possible implications for epigenetic regulation in hypoxic disease states

  2. Here we show that JMJD2A, the first identified Jumonji (show JARID2 Proteins) C domain-containing histone demethylase (show MBD2 Proteins), is the histone demethylase (show MBD2 Proteins) responsible for SUMO-2 (show SUMO2 Proteins)/3 enrichment on the Kaposi's sarcoma associated herpesvirus genome during viral reactivation

  3. Lgr4 (show LGR4 Proteins) activates Jmjd2a/AR signaling pathway to promote interaction AR with PSA (show PLAG1 Proteins) promoter, causing reduction of prostate cancer apoptosis and cell cycle arrest.

  4. We demonstrate the previously unreported inhibitory action of PKF118-310 on KDM4A. Our findings open up the possibility of developing the first KDM4A-specific inhibitors and derivatives.

  5. KDM4A downregulation promotes autophagy in glioma cell lines.

  6. ERG (show ERG Proteins) promotes prostate tumorigenesis together with KDM4A through the upregulation of YAP1 (show YAP1 Proteins). A corollary is that KDM4A as well as YAP1 (show YAP1 Proteins) inhibitors may prove beneficial for the therapy of ERG (show ERG Proteins)-overexpressing prostate tumors.

  7. In pancreatic neoplasms, miR (show MLXIP Proteins)-137 targets KDM4A mRNA during Ras-induced senescence and activates both p53 (show TP53 Proteins) and retinoblastoma (pRb (show RB1 Proteins)) tumor suppressor pathways.

  8. Study demonstrates that JMJD2A contributes to tumorigenesis in non-small cell lung cancer (NSCLC) by regulating miR (show MLXIP Proteins)-150. Additionally, JMJD2A overexpression is associated with a poor prognosis for NSCLC patients.

  9. High KDM4A expression is associated with endometrial cancer progression.

  10. Studies indicate that histone lysine demethylase (show MBD2 Proteins) (JmjC-KDM) KDM4A protein has been implicated in numerous cancers and cardiovascular diseases.

Mouse (Murine) Lysine (K)-Specific Demethylase 4A (KDM4A) interaction partners

  1. We propose the inhibition of KDM4A activity as a strategy to suppress IL-6 (show IL6 Proteins) production and attenuate colitis induction.

  2. The authors show that Jmjd2a and Jmjd2c (show KDM4C Proteins) both localize to H3K4me3-positive promoters, where they have widespread and redundant roles in preventing accumulation of H3K9me3 and H3K36me3.

  3. these data reveal a JMJD2A/ETV1 (show ETV1 Proteins)/YAP1 (show YAP1 Proteins) axis that promotes prostate cancer initiation and that may be a suitable target for therapeutic inhibition.

  4. Results indicate that SCF (show KITLG Proteins)(Fbxo22 (show FBXO22 Proteins))-KDM4A is an E3 ubiquitin ligase (show MUL1 Proteins) that targets methylated p53 (show TP53 Proteins) and regulates key senescent processes.

  5. These findings together demonstrate the essential role of KDM4A and KDM4C (show KDM4C Proteins) in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 (show KDR Proteins) and VE-cadherin (show CDH5 Proteins) promoters, respectively

  6. As well as three novel motifs in JMJD2A-regulated genes.

  7. JMJD2A bound to the FHL1 (show FHL1 Proteins) promoter in response to TAC (show IL2RA Proteins), upregulated FHL1 (show FHL1 Proteins) expression, and downregulated H3K9 trimethylation. JMJD2A promotes cardiac hypertrophy under pathological conditions by a novel mechanism.

  8. JHDM3A(GFP)(701) is a suitable catalytic module that can be targeted, under the control of a guide protein, to specific loci where the chromatin H3K9me3 status and the milieu of gene expression are to be modified.

Cow (Bovine) Lysine (K)-Specific Demethylase 4A (KDM4A) interaction partners

  1. Histone demethylases KDM3A (show KDM3A Proteins), KDM4A, and KDM4C (show KDM4C Proteins) were expressed before and after embryonic genome activation, whereas KDM5B (show KDM5B Proteins) was mainly expressed during the blastocyst period.

KDM4A Protein Profile

Protein Summary

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.

Gene names and symbols associated with KDM4A

  • jumonji domain containing 2A (JMJD2A)
  • lysine (K)-specific demethylase 4A (KDM4A)
  • jumonji domain containing 2A (LOC100353935)
  • lysine (K)-specific demethylase 4A (Kdm4a)
  • D4Ertd222e protein
  • JHDM3A protein
  • Jmjd2 protein
  • Jmjd2a protein
  • mKIAA0677 protein
  • TDRD14A protein

Protein level used designations for KDM4A

jumonji domain containing 2A , lysine (K)-specific demethylase 4A , lysine-specific demethylase 4A , jumonji domain-containing protein 2A , JmjC domain-containing histone demethylation protein 3A , jumonji domain-containing 2A , lysine-specific demethylase 4A-like , jmjC domain-containing histone demethylation protein 3A , jumonji C domain-containing histone demethylase 3A , jumonji domain containing 2 , tudor domain containing 14A

GENE ID SPECIES
424571 Gallus gallus
456829 Pan troglodytes
701272 Macaca mulatta
100172003 Pongo abelii
100353935 Oryctolagus cuniculus
100228023 Taeniopygia guttata
100294710 Sus scrofa
100473204 Ailuropoda melanoleuca
100544296 Meleagris gallopavo
9682 Homo sapiens
230674 Mus musculus
313539 Rattus norvegicus
482530 Canis lupus familiaris
512622 Bos taurus
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