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KDM5C is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. Additionally we are shipping KDM5C Proteins (4) and many more products for this protein.
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Human Polyclonal KDM5C Primary Antibody for IP, WB - ABIN188638
Smith, Haberstroh, White, Livingston, DeCaprio, Howley: SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. in Virology 2014
Show all 2 references for ABIN188638
The predicted structure of KDM5C was used to investigate the effects of disease-causing mutations, and it was shown that the mutations alter domain stability and inter-domain interactions.
Results suggest that KDM5C mutations predispose to X-linked intellectual disability which accounts for 1-4% of cases in male patient.
the extent of the duplicated regions in each case encompassing a minimum of three known disease genes TSPYL2 (show TSPYL2 Antibodies), KDM5C and IQSEC2 (show IQSEC2 Antibodies), is reported.
KDM5C is overexpressed in breast cancer cells and miR (show MLXIP Antibodies)-138 regulates its expression.
study of non-synonymous mutations in the KDM5C ARID domain and evaluates effects of 2 syndromic Claes-Jensen-type disease-associated missense mutations (A77T and D87G) and 3 non-classified missense mutations (R108W, N142S, and R179H); analysis indicates, among the non-classified mutations, R108W is possibly a disease-associated mutation, and N142S and R179H are probably harmless
Findings reveal a RACK7 (show ZMYND8 Antibodies)/KDM5C-regulated, dynamic interchange between histone H3K4me1 and H3K4me3 at active enhancers, representing an additional layer of regulation of enhancer activity. Authors propose that RACK7 (show ZMYND8 Antibodies)/KDM5C functions as an enhancer "brake" to ensure appropriate enhancer activity, which, when compromised, could contribute to tumorigenesis.
Expression of KDM5C in hepatocellular carcinoma tumor cells promoted cell migration and tumor invasion.
Characterization of a Linked Jumonji (show JARID2 Antibodies) Domain of the KDM5/JARID1 Family of Histone H3 (show HIST3H3 Antibodies) Lysine 4 Demethylases.
these data suggest that inactivation of JARID1C in renal cancer leads to heterochromatin disruption, genomic rearrangement, and aggressive ccRCCs.
Mutations in KDM5C gene in patients are described and their effect on gene expression, stability and catalytic activity is examined. Patient fibroblasts do not show global changes in histone methylation but several up-regulated genes were identified.
Neurite growth in Neuro2a cells was suppressed by the KDM5C mutations associated with intellectual disability in patients. Ntng2 (show NTNG2 Antibodies) was downregulated in cells with KDM5C mutations, concordant with the lower levels of H3K4 methylation at its promoter.
The present study was designed to detect the expression of Histone H3 (show HIST3H3 Antibodies) lysine 4 methylation and its demethylases LSD1 (show KDM1A Antibodies), RBP2 (show RBP2 Antibodies) and SMCX in 21-, 40- and 60-day-old mouse testes.
Kdm5c protein restricts transcriptional output at promoters, whereas Kdm5c binding to enhancers stimulates their activity.
sex-specific expression of Jarid1c may contribute to sex differences in brain function
allelic expression and RNA/DNA FISH indicate that transgenic Jarid1c escapes X inactivation.
The full-length cDNA of JARID1C has been cloned.
This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants.
histone demethylase JARID1C
, lysine (K)-specific demethylase 5C
, jumonji, AT rich interactive domain 1C
, JmjC domain-containing protein SMCX
, Jumonji, AT rich interactive domain 1C (RBP2-like)
, Jumonji/ARID domain-containing protein 1C
, Smcx homolog, X chromosome
, Smcy homolog, X-linked
, lysine-specific demethylase 5C
, protein SmcX
, selected cDNA on X
, jumonji, AT rich interactive domain 1C (Rbp2 like)
, jumonji/ARID domain-containing protein 1C
, selected mouse cDNA on the X
, lysine (K)-specific demethylase 5C tv1
, Lysine-specific demethylase 5C