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Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Additionally we are shipping and Kdm6b Kits (1) and many more products for this protein.
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Human Polyclonal Kdm6b Primary Antibody for IF, IHC (p) - ABIN387862
Lu, Lu, Liao, Yu, Chung, Kao, Wu: Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. in The Journal of biological chemistry 2010
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Human Polyclonal Kdm6b Primary Antibody for FACS, ICC - ABIN438547
Pham, Yu, Walline, Muthukrishnan, Blum, Kaplan: Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. in Journal of immunology (Baltimore, Md. : 1950) 2013
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Human Polyclonal Kdm6b Primary Antibody for WB - ABIN387864
Shaw, Martin: Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. in EMBO reports 2009
Cow (Bovine) Polyclonal Kdm6b Primary Antibody for WB - ABIN2778610
Hong, Cho, Yu, Yu, Veenstra, Ge: Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. in Proceedings of the National Academy of Sciences of the United States of America 2007
loss of both kdm6ba and kdm6bb shows Kdm6b proteins share redundant and pleiotropic roles in organogenesis without impacting initial cell fate specification.
Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal (show CAD Antibodies) fin regeneration, and that Kdm6b.1 may be the histone demethylase (show MBD2 Antibodies) required during regeneration.
These results suggest that the demethylase (show MBD2 Antibodies) activity of Jmjd3, but not that of Utx (show KDM6A Antibodies), affects mouse axial patterning in concert with alterations in Hox (show MSH2 Antibodies) gene expression.
Direct genetic and molecular evidence that JMJD3 is a key mediator for the kisspeptin-estrogen feedback loop.
Knockdown of Kdm6b in chondrocytes leads to abnormal cartilage development and accelerated osteoarthritis progression via inhibition of the anabolic metabolism of chondrocytes. The number of Kdm6b-positive chondrocytes was lower in osteoarthritis cartilage samples.
Preliminary evidence suggests a role of JMJD3 in removal of H3K27me3 mark from promoters of hepatic transcription factors, thus activating epigenetically poised hepatic genes in bone marrow progenitor cells prior to partial nuclear reprogramming.
Study provides evidence that miR (show MLXIP Antibodies)-148a-3p reciprocally regulates adipocyte and osteoblast differentiation through directly targeting Kdm6b.
the redox regulation of Jmjd3 is a unique regulatory mechanism for Cu,Zn-superoxide dismutase (show SOD1 Antibodies)-mediated profibrotic macrophage polarization.
our study has attributed novel roles for JMJD3 and its regulators during mycobacterial infection that assist foamy macrophage generation and fine-tune associated host immunity
ISL1 (show ISL1 Antibodies) and JMJD3 partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac differentiation.
Histone H3 (show HIST3H3 Antibodies) lysine-27 demethylase (show MBD2 Antibodies) (H3K27me3 demethylase (show MBD2 Antibodies)) activity would act as a negative regulator of dendritic cells (DCs).
nuc-ErbB3 (show ERBB3 Antibodies) directly regulates levels of H3K27me3 in Schwann cells
results demonstrate that the regulation of Jmjd3 by STAT3 (show STAT3 Antibodies) maintains repression of differentiation specific genes and is therefore important for the maintenance of self-renewal of normal neural and glioblastoma stem cells
Data show that histone demethylase (show MBD2 Antibodies) JMJD3 was reduced and its target gene Snai1 (show SNAI1 Antibodies) expression was down-regulated after HOTAIR suppression.
The number of Kdm6b-positive chondrocytes was lower in human osteoarthritis cartilage samples.
Kdm6a (show KDM6A Antibodies) and Kdm6b were found to be significantly overexpressed in Malignant pleural mesothelioma (MPM) at the mRNA level. However, tests examining if targeting therapeutically Kdm6a (show KDM6A Antibodies)/b using a specific small molecule inhibitor was potentially useful for treating MPM, revealed that members of the Kdm6 family may not be suitable candidates for therapy
Lipopolysaccharide treatment recruited Jmjd3 and NF-kappaB (show NFKB1 Antibodies) to the promoter region of target genes, suggesting Jmjd3 synergizes with NF-kappaB (show NFKB1 Antibodies) to activate the expression of target genes.
Incubation of nickel chloride upregulated the expression of H3K27me3 demethylase (show MBD2 Antibodies) jumonji domain-containing protein 3 (JMJD3) in kidney cancer cells, which was accompanied by the reduction in the protein level of H3K27me3. Enhanced demethylation of H3K27me3 may represent a novel mechanism underlying the carcinogenicity of nickel compounds.
JMJD3 gene expression in renal cell carcinoma (show MOK Antibodies) and bladder cancer.
JMJD3 and EZH2 (show EZH2 Antibodies) in prostate biopsies also demonstrated an increase of JMJD3 and EZH2 (show EZH2 Antibodies) in adenocarcinoma with Gleason score 7 and 8 by comparison with a normal biopsy.
Low JMJD3 expression is associated with Colorectal Cancer.
JMJD3 up-regulation and NF-kappaB (show NFKB1 Antibodies) activation occur in the region of the wound edge during keratinocyte wound healing
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
jumonji domain containing 3
, lysine (K)-specific demethylase 6B
, jumonji domain containing 3, histone lysine demethylase
, lysine-specific demethylase 6B-like
, jmjC domain-containing protein 3
, jumonji domain-containing protein 3
, lysine-specific demethylase 6B
, lysine demethylase 6B
, jumonji domain-containing 3