anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) Antibodies

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Additionally we are shipping and Kdm6b Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Kdm6b 216850 Q5NCY0
Kdm6b 23135 O15054
Kdm6b 363630  
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Top anti-Kdm6b Antibodies at antibodies-online.com

Showing 10 out of 99 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of anti-JMJD3 N-term Pab (ABIN387862) in Hela cell line lysates. JMJD3 N-term(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with JMJD3 N-term (ABIN387862), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-JMJD3 Center Pab (ABIN387864) in Hela cell line lysates. JMJD3 Center(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, ICC, IF, WB Immunocytochemistry/Immunofluorescence: Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody [NBP1-06640] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-JMJD3 [NBP1-06640] at a 1:200 dilution overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:500 dilution. Alpha tubulin (DM1A) [ABIN438547] was used as a co-stain at a 1:1000 dilution and detected with an anti-mouse Dylight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective. 0.1 mL Log in to see 7 to 9 Days
$473.81
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-JMJD3 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate Host: Rabbit  Target Name: JMJD3  Sample Tissue: HepG2Lane A:  Primary Antibody Lane B:  Primary Antibody + Blocking Peptide Primary Antibody Concentration: 2.5 µg/mL Peptide Concentration:..0 µg/mL Lysate Quantity:.41 µg/laneGel Concentration:.%-18 % 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 10 to 12 Days
$375.38
Details
Cow Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Mouse Un-conjugated WB JMJD3/ KDM6B mAb (Clone 67-A2) tested by Western blot. JMJD3/ KDM6B detection by Western blot. The analysis was performed using cell lysate from BJ cells (lane 1) and BJ cells irradiated (lane 2). 100 μg Log in to see 1 to 2 Days
$495.83
Details

Kdm6b Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Rat (Rattus)


Top referenced anti-Kdm6b Antibodies

  1. Human Polyclonal Kdm6b Primary Antibody for IF, IHC (p) - ABIN387862 : Lu, Lu, Liao, Yu, Chung, Kao, Wu: Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 13 references for 387862

  2. Human Polyclonal Kdm6b Primary Antibody for FACS, ICC - ABIN438547 : Pham, Yu, Walline, Muthukrishnan, Blum, Kaplan: Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. in Journal of immunology (Baltimore, Md. : 1950) 2013 (PubMed)
    Show all 2 references for 438547

  3. Human Polyclonal Kdm6b Primary Antibody for WB - ABIN387864 : Shaw, Martin: Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. in EMBO reports 2009 (PubMed)

  4. Cow (Bovine) Polyclonal Kdm6b Primary Antibody for WB - ABIN2778610 : Hong, Cho, Yu, Yu, Veenstra, Ge: Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

More Antibodies against Kdm6b Interaction Partners

Zebrafish Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. loss of both kdm6ba and kdm6bb shows Kdm6b proteins share redundant and pleiotropic roles in organogenesis without impacting initial cell fate specification.

  2. Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal (show CAD Antibodies) fin regeneration, and that Kdm6b.1 may be the histone demethylase (show MBD2 Antibodies) required during regeneration.

Mouse (Murine) Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. These results suggest that the demethylase (show MBD2 Antibodies) activity of Jmjd3, but not that of Utx (show KDM6A Antibodies), affects mouse axial patterning in concert with alterations in Hox (show MSH2 Antibodies) gene expression.

  2. Direct genetic and molecular evidence that JMJD3 is a key mediator for the kisspeptin-estrogen feedback loop.

  3. Knockdown of Kdm6b in chondrocytes leads to abnormal cartilage development and accelerated osteoarthritis progression via inhibition of the anabolic metabolism of chondrocytes. The number of Kdm6b-positive chondrocytes was lower in osteoarthritis cartilage samples.

  4. Preliminary evidence suggests a role of JMJD3 in removal of H3K27me3 mark from promoters of hepatic transcription factors, thus activating epigenetically poised hepatic genes in bone marrow progenitor cells prior to partial nuclear reprogramming.

  5. Study provides evidence that miR (show MLXIP Antibodies)-148a-3p reciprocally regulates adipocyte and osteoblast differentiation through directly targeting Kdm6b.

  6. the redox regulation of Jmjd3 is a unique regulatory mechanism for Cu,Zn-superoxide dismutase (show SOD1 Antibodies)-mediated profibrotic macrophage polarization.

  7. our study has attributed novel roles for JMJD3 and its regulators during mycobacterial infection that assist foamy macrophage generation and fine-tune associated host immunity

  8. ISL1 (show ISL1 Antibodies) and JMJD3 partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac differentiation.

  9. Histone H3 (show HIST3H3 Antibodies) lysine-27 demethylase (show MBD2 Antibodies) (H3K27me3 demethylase (show MBD2 Antibodies)) activity would act as a negative regulator of dendritic cells (DCs).

  10. nuc-ErbB3 (show ERBB3 Antibodies) directly regulates levels of H3K27me3 in Schwann cells

Human Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. results demonstrate that the regulation of Jmjd3 by STAT3 (show STAT3 Antibodies) maintains repression of differentiation specific genes and is therefore important for the maintenance of self-renewal of normal neural and glioblastoma stem cells

  2. Data show that histone demethylase (show MBD2 Antibodies) JMJD3 was reduced and its target gene Snai1 (show SNAI1 Antibodies) expression was down-regulated after HOTAIR suppression.

  3. The number of Kdm6b-positive chondrocytes was lower in human osteoarthritis cartilage samples.

  4. Kdm6a (show KDM6A Antibodies) and Kdm6b were found to be significantly overexpressed in Malignant pleural mesothelioma (MPM) at the mRNA level. However, tests examining if targeting therapeutically Kdm6a (show KDM6A Antibodies)/b using a specific small molecule inhibitor was potentially useful for treating MPM, revealed that members of the Kdm6 family may not be suitable candidates for therapy

  5. Lipopolysaccharide treatment recruited Jmjd3 and NF-kappaB (show NFKB1 Antibodies) to the promoter region of target genes, suggesting Jmjd3 synergizes with NF-kappaB (show NFKB1 Antibodies) to activate the expression of target genes.

  6. Incubation of nickel chloride upregulated the expression of H3K27me3 demethylase (show MBD2 Antibodies) jumonji domain-containing protein 3 (JMJD3) in kidney cancer cells, which was accompanied by the reduction in the protein level of H3K27me3. Enhanced demethylation of H3K27me3 may represent a novel mechanism underlying the carcinogenicity of nickel compounds.

  7. JMJD3 gene expression in renal cell carcinoma (show MOK Antibodies) and bladder cancer.

  8. JMJD3 and EZH2 (show EZH2 Antibodies) in prostate biopsies also demonstrated an increase of JMJD3 and EZH2 (show EZH2 Antibodies) in adenocarcinoma with Gleason score 7 and 8 by comparison with a normal biopsy.

  9. Low JMJD3 expression is associated with Colorectal Cancer.

  10. JMJD3 up-regulation and NF-kappaB (show NFKB1 Antibodies) activation occur in the region of the wound edge during keratinocyte wound healing

Kdm6b Antigen Profile

Protein Summary

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

Gene names and symbols associated with Kdm6b

  • jumonji domain containing 3 (jmjd3) antibody
  • lysine (K)-specific demethylase 6B (KDM6B) antibody
  • lysine (K)-specific demethylase 6B, b (kdm6bb) antibody
  • lysine (K)-specific demethylase 6B (LOC100140276) antibody
  • lysine (K)-specific demethylase 6B (LOC100343083) antibody
  • KDM1 lysine (K)-specific demethylase 6B (Kdm6b) antibody
  • lysine (K)-specific demethylase 6B (Kdm6b) antibody
  • 1700064E03Rik antibody
  • BC038313 antibody
  • JMJD3 antibody
  • kdm6b antibody
  • mKIAA0346 antibody
  • si:ch211-237l4.7 antibody

Protein level used designations for Kdm6b

jumonji domain containing 3 , lysine (K)-specific demethylase 6B , jumonji domain containing 3, histone lysine demethylase , lysine-specific demethylase 6B-like , jmjC domain-containing protein 3 , jumonji domain-containing protein 3 , lysine-specific demethylase 6B , lysine demethylase 6B , jumonji domain-containing 3

GENE ID SPECIES
779446 Xenopus (Silurana) tropicalis
468438 Pan troglodytes
563644 Danio rerio
716348 Macaca mulatta
100414637 Callithrix jacchus
100140276 Bos taurus
100343083 Oryctolagus cuniculus
216850 Mus musculus
23135 Homo sapiens
489481 Canis lupus familiaris
363630 Rattus norvegicus
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