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Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Additionally we are shipping and Kdm6b Kits (1) and many more products for this protein.
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Human Polyclonal Kdm6b Primary Antibody for IF, IHC (p) - ABIN387862
Lu, Lu, Liao, Yu, Chung, Kao, Wu: Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. in The Journal of biological chemistry 2010
Show all 13 references for ABIN387862
Human Polyclonal Kdm6b Primary Antibody for EIA, IF - ABIN1450111
De Santa, Totaro, Prosperini, Notarbartolo, Testa, Natoli: The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. in Cell 2007
Show all 3 references for ABIN1450111
Dog (Canine) Polyclonal Kdm6b Primary Antibody for WB - ABIN2778610
Hong, Cho, Yu, Yu, Veenstra, Ge: Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. in Proceedings of the National Academy of Sciences of the United States of America 2007
Human Polyclonal Kdm6b Primary Antibody for FACS, ICC - ABIN438547
Pham, Yu, Walline, Muthukrishnan, Blum, Kaplan: Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. in Journal of immunology (Baltimore, Md. : 1950) 2013
Human Polyclonal Kdm6b Primary Antibody for WB - ABIN387864
Shaw, Martin: Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. in EMBO reports 2009
Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal (show CAD Antibodies) fin regeneration, and that Kdm6b.1 may be the histone demethylase (show MBD2 Antibodies) required during regeneration.
nuc-ErbB3 (show ERBB3 Antibodies) directly regulates levels of H3K27me3 in Schwann cells
differentiating embryonic stem cells (ESCs (show NR2E3 Antibodies)) depend on KDM6 and the H3K27me3 demethylase (show MBD2 Antibodies) activity is crucially involved in DNA damage response and survival of differentiating ESCs (show NR2E3 Antibodies).
JMJD3 up-regulation and NF-kappaB (show NFKB1 Antibodies) activation occur in the region of the wound edge during keratinocyte wound healing
these studies established a critical role of Jmjd3-mediated H3K27 demethylation in Th17 cell differentiation and suggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses.
These results strongly demonstrated that JMJD3 is required for osteoblast differentiation and bone formation in mice.
APN (show ANPEP Antibodies) can help to reduce periodontitis-related bone loss, modulate JMJD3 and IRF4 (show IRF4 Antibodies) expression, and macrophage infiltration.
JMJD3 is an epigenetic regulator in development and disease. (Review)
Jmjd3 is required for T-cell development.
Jmjd3-catalyzed erasure of H3K27me3 is required for brown fat gene expression and browning of white fat.
Utx (show KDM6A Antibodies) and Jmjd3 mutant mouse embryonic fibroblasts (MEFs) demonstrate dramatic loss of H3K27me3 from promoters of several Hox (show MSH2 Antibodies) genes and transcription factors.
Incubation of nickel chloride upregulated the expression of H3K27me3 demethylase (show MBD2 Antibodies) jumonji domain-containing protein 3 (JMJD3) in kidney cancer cells, which was accompanied by the reduction in the protein level of H3K27me3. Enhanced demethylation of H3K27me3 may represent a novel mechanism underlying the carcinogenicity of nickel compounds.
JMJD3 gene expression in renal cell carcinoma (show MOK Antibodies) and bladder cancer.
JMJD3 and EZH2 (show EZH2 Antibodies) in prostate biopsies also demonstrated an increase of JMJD3 and EZH2 (show EZH2 Antibodies) in adenocarcinoma with Gleason score 7 and 8 by comparison with a normal biopsy.
Low JMJD3 expression is associated with Colorectal Cancer.
JMJD3 promotes SAHF formation by demethylating RB at K810, which reduce the level of phosphorylation of RB protein at S807/811, and this interplay promotes the formation of senescence-associated heterochromatin foci in senescent WI38 cells.
We demonstrate that KDM6B plays a key role in clear cell renal cell carcinoma (show MOK Antibodies)
Jmjd3 regulates osteoblast apoptosis through targeting Bcl-2 (show BCL2 Antibodies) expression and Bim (show BCL2L11 Antibodies) phosphorylation.
Findings reveal a novel epigenetic mechanism by which JMJD3 promotes melanoma progression and metastasis.
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
jumonji domain containing 3
, lysine (K)-specific demethylase 6B
, jumonji domain containing 3, histone lysine demethylase
, lysine-specific demethylase 6B-like
, jmjC domain-containing protein 3
, jumonji domain-containing protein 3
, lysine-specific demethylase 6B
, lysine demethylase 6B
, jumonji domain-containing 3