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Acyl-CoA:lysocardiolipin acyltransferase. Additionally we are shipping and many more products for this protein.
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Human Polyclonal LCLAT1 Primary Antibody for WB - ABIN2781857
Wang, Faloon, Tan, Lv, Zhang, Ge, Deng, Xiong: Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation. in Blood 2007
Data indicate that lycat is the earliest known player in the generation of both endothelial and hematopoietic lineages.
LYCAT expression was significantly altered in PBMCs and lung tissues from patients with idiopathic pulmonary fibrosis.
Data show that ALCAT1 possesses acyltransferase activities toward lysophosphatidylinositol and lysophosphatidylglycerol, and identify critical amino acids that are potentially involved in lysophospholipid substrate binding.
Alcat1 is destabilized in epithelia by lipopolysaccharide (LPS (show TLR4 Antibodies)) impairing mitochondrial function.
Differential reduction in cardiac and liver monolysocardiolipin acyltransferase-1 and reduction in cardiac and liver tetralinoleoyl-cardiolipin in the alpha-subunit (show POLG Antibodies) of trifunctional protein heterozygous knockout mice
pathological cardiolipin remodeling by ALCAT1 linked to the pathogenesis of nonalcoholic fatty liver diseases
LYCAT expression was altered in peripheral blood mononuclear cells and outcome in pulmonary fibrosis.
findings implicate a key role of ALCAT1 as the missing link between oxidative stress and mitochondrial dysfunction in the etiology of age-related heart diseases
overexpression of ALCAT1 causes mitochondrial fragmentation through oxidative stress and depletion of mitofusin mitofusin (show MFN2 Antibodies) 2 (MFN2 (show MFN2 Antibodies)) expression
Data indicate that LYCAT is a determinant of PI molecular species and its function is conserved in C. elegans and mammals.
ALCAT1 deficiency prevented the onset of DIO and significantly improved mitochondrial complex I activity, lipid oxidation, and insulin (show INS Antibodies) signaling.
Expression of Lclat1 gene in the mouse cardiovascular system is reported.
identification and characterization of a gene that encodes an acyl-CoA:lysocardiolipin acyltransferase 1
Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.
lysocardiolipin acyltransferase 1
, 1-acylglycerol-3-phosphate O-acyltransferase 8
, 1-AGP acyltransferase 8
, 1-AGPAT 8
, acyl-CoA:lysocardiolipin acyltransferase 1