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The protein encoded by LOX is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. Additionally we are shipping LOX Antibodies (184) and LOX Proteins (13) and many more products for this protein.
Showing 10 out of 38 products:
Human LOX ELISA Kit for Sandwich ELISA - ABIN418267
Tadmor, Bejar, Attias, Mischenko, Sabo, Neufeld, Vadasz: The expression of lysyl-oxidase gene family members in myeloproliferative neoplasms. in American journal of hematology 2013
Show all 7 references for ABIN418267
Partial knockdown of lysyl oxidase genes sensitizes the developing embryo to dithiocarbamate exposure.
Data reveal a role for lysyl oxidase in early morphogenesis, especially in muscle development and neurogenesis, and resume some aspects of physiopathology of copper metabolism.
endogenous LOX is overexpressed in clear cell renal cell carcinoma, is involved in a positive-regulative loop with HIF-1alpha, and has a major action on clear cell renal cell carcinoma progression through cellular adhesion, migration, and collagen matrix stiffness increment
colorectal carcinoma perilesional extracellular matrix has increased content of lysyl oxidase
LOX affects the epithelial-mesenchymal transition of gastric cancer cells in hypoxic conditions.
High expression of LOX is associated with nasopharyngeal carcinoma.
Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue
Results show that LOX expression regulation by FoxF1 (show FOXF1 ELISA Kits) increases invasiveness of breast cancer cells.
LOX gene expression was approximately 2.5-fold higher in fetal membranes from preterm prelabor rupture of membranes (pPROM (show SERPINH1 ELISA Kits)) compared to preterm and term birth.
The data suggest a fibromodulin (show FMOD ELISA Kits)-modulated collagen cross-linking mechanism where fibromodulin (show FMOD ELISA Kits) binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cross-linking sites.
Cu chaperone function of Atox1 (show ATOX1 ELISA Kits) mediated through Cu transporter ATP7A (show ATP7A ELISA Kits) is required for VEGF (show VEGFA ELISA Kits)-induced angiogenesis via activation of Cu enzyme lysyl oxidase.
Our study demonstrated that the LOX rs1800449 genotypes (AA and GA + AA) and allele (A) appears to confer risk for susceptibility to keratoconus.
Statins normalize vascular lysyl oxidase (LOX) down-regulation induced by proatherogenic risk factors.
These results indicate that proLOX could be processed by two different mechanisms producing two forms of active LOX.
Lysyl oxidase enhances elastin (show ELN ELISA Kits) synthesis and matrix formation by vascular smooth muscle cells
Lysyl oxidase has a role in oxidizing basic fibroblast growth factor (show FGF2 ELISA Kits) and inactivating its mitogenic potential
In cases of vascular calcification, the decreased expression of LOX may be partially responsible for decreased vascular elasticity and also for the decreased formation of new elastic fibers.
Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.
LOX family members contribute significantly to the detrimental effects of cardiac remodelling, highlighting LOX inhibition as a potential therapeutic strategy for post-infarction recovery
Findings suggest that the lysyl oxidase (LOX)-mediated organization of collagen fibers in the extracellular matrix is an important regulator of osteoblastogenesis.
Data suggest of pharmacologic targeting of lysyl oxidase (LOX) pathway to inhibit liver fibrosis and promote its resolution.
CTR1 (show SLC31A1 ELISA Kits), ATP7A (show ATP7A ELISA Kits), and lysyl oxidase were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.
Inhibition of tissue transglutaminase (show TGM2 ELISA Kits) resulted in a reduced rate of compaction compared to controls during early remodeling (up to 2 days). In contrast, inhibition of lysyl oxidase did not alter the early compaction.
decreased expression of cross-linking enzymes (LOXs) and increased expression of ECM-degrading proteinases (MMP-1, 2, 3) might be of great contribution to poor healing ability of PCL ligament
LOX is indispensable for the progression of BLM-induced experimental lung fibrosis by aggravating the inflammatory response and subsequent fibrosis process after lung injury.
LOX and LOXL2 (show LOXL3 ELISA Kits) may play an important role in the pathogenesis of AMD (show AMD1 ELISA Kits). Targeting LOXL2 (show LOXL3 ELISA Kits) could have a broader efficacy than targeting LOX, by reducing angiogenesis and inflammation, as well as fibrosis.
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
, protein-lysine 6-oxidase-like
, protein-lysine 6-oxidase
, ras excision protein
, ras recision gene (rrg)
, Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)