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Involved in transcriptional regulation. Additionally we are shipping M-Phase phosphoprotein 8 Antibodies (18) and many more products for this protein.
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The haploid screen identified HUSH, an epigenetic heterochromatin repressor complex composed of three subunits, TASOR, MPP8 and Periphilin (show PPHLN1 Proteins). (Review)
findings demonstrate MPP8 and SIRT1 (show SIRT1 Proteins) reciprocally regulate each other's function at multiple molecular layers through physical interaction; disruption of MPP8-SIRT1 (show SIRT1 Proteins) interaction de-represses E cadherin (show CDH1 Proteins) expression and reduces cell motility and invasiveness suggesting this interplay plays critical role in MPP8- and SIRT1 (show SIRT1 Proteins)-mediated epithelial-mesenchymal transition
this study identified the HUSH (human silencing hub) complex, comprising three poorly characterized proteins, TASOR, MPP8, and periphilin (show PPHLN1 Proteins); this complex is absent from Drosophila but is conserved from fish to humans.
Knockdown analysis of MPP8 in HeLa cells resulted in derepression of a set of genes that are normally expressed in spermatogonia, spermatids and mature sperm, thereby indicating a role for this molecule in silencing testis-related genes in somatic cells.
interaction of HN with MPP8 may play a role in oncogenesis because MPP8 increases tumor cell motility and invasion
these results indicate that the chromatin association of MPP8 is regulated by Cdk (show CDK4 Proteins)-dependent phosphorylation.
These findings reveal the molecular mechanism of selective binding of human MPP8 chromodomain to methylated histone H3K9.
We determined the crystal structure of MPP8 chromodomain in complex with H3K9me3 peptide. MPP8 interacts with at least six histone H3 residues from glutamine 5 to serine 10.
MPP8 mediates E-cadherin (show CDH1 Proteins) gene silencing and promotes breast tumour cell motility and invasion.
Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites\; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression (By similarity).
M-phase phosphoprotein, mpp
, M-phase phosphoprotein, mpp8
, two hybrid-associated protein 3 with RanBPM