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human homolog is upregulated by estrogen in a breast cancer cell line; may play a role in cell proliferation. Additionally we are shipping and and many more products for this protein.
The results indicate that abnormal LRP16 expression is noted in neuroendocrine lung tumors and the expression can give insight into the pathogenesis of the disease.
LRP16, through its constitutive interactions with PARP1 (show PARP1 ELISA Kits) and IKKgamma (show IKBKG ELISA Kits), functions to facilitate the lesion-specific recruitment of PARP1 (show PARP1 ELISA Kits) and IKKgamma (show IKBKG ELISA Kits) and, ultimately, the concomitant recruitment of PIASy (show PIAS4 ELISA Kits) to IKKgamma (show IKBKG ELISA Kits) in response to DNA damage.
LRP16 gene overexpression shows a promotive effect on proliferation of K562 cells.
LRP16 may play an important role in leukemia progression by promoting cell proliferation, regulating cell cycle, and antagonizing radiation-induced DNA damage.
Findings not only indicate that LRP16 is a crucial regulator for NF-kappaB (show NFKB1 ELISA Kits) activation inside the nucleus, but also suggest that LRP16 may be an important contributor to the aberrant activation of NF-kappaB (show NFKB1 ELISA Kits) in tumors.
lrp16 is a leukemic oncogene (show RAB1A ELISA Kits) and closely relates to genesis and progression of leukemia.
LRP16 expression is related to the degree of differentiation, invasiveness, metastasis and prognosis of colorectal carcinoma.
K18 (show KRT18 ELISA Kits) attenuates estrogen receptor alpha (show ESR1 ELISA Kits)-mediated signaling by sequestering LRP16 in cytoplasm.
LRP16 may have a role in invasion, metastasis and prognosis of gastric cancer
ERalpha (show ESR1 ELISA Kits) and Sp1 (show PSG1 ELISA Kits) play a role in activation of the promoter
These results suggest that LRP16 plays a key role in maintaining pancreatic beta-cell functions and may help us to understand the protective effects of estrogen on the functions of pancreatic beta-cells.
LRP16 acts as a negative regulator of insulin (show INS ELISA Kits) action and adipogenesis in 3T3-L1 adipocytes.
LRP16 played important roles not only in insulin (show INS ELISA Kits) content and GSIS but also in the antilipotoxic effect mediated by Akt (show AKT1 ELISA Kits)/FoxO1 (show FOXO1 ELISA Kits) signaling.
LRP16 gene causes insulin (show INS ELISA Kits) resistance in C2-C12 cells by inhibiting the IRS-1 (show IRS1 ELISA Kits) signaling and the transcriptional activity of PPARgamma (show PPARG ELISA Kits).
human homolog is upregulated by estrogen in a breast cancer cell line; may play a role in cell proliferation
MACRO domain containing 1
, LRP16 protein
, MACRO domain-containing protein 1
, O-acetyl-ADP-ribose deacetylase MACROD1
, [Protein ADP-ribosylglutamate] hydrolase