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MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. Additionally we are shipping MAD1L1 Proteins (5) and MAD1L1 Kits (2) and many more products for this protein.
Showing 10 out of 80 products:
Human Polyclonal MAD1L1 Primary Antibody for EIA, WB - ABIN953276
Guo, Zhang, Yang, Miao, Shi, Yao, Tan, Sun, Zhao, Yu, Liu, Lin: Functional evaluation of missense variations in the human MAD1L1 and MAD2L1 genes and their impact on susceptibility to lung cancer. in Journal of medical genetics 2010
Show all 5 references for ABIN953276
Human Monoclonal MAD1L1 Primary Antibody for IF, IP - ABIN567785
Haller, Kibler, Kasai, Chi, Peloponese, Yedavalli, Jeang: The N-terminus of rodent and human MAD1 confers species-specific stringency to spindle assembly checkpoint. in Oncogene 2006
Show all 3 references for ABIN567785
Human Polyclonal MAD1L1 Primary Antibody for WB - ABIN656281
Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: An approach based on a genome-wide association study reveals candidate loci for narcolepsy. in Human genetics 2010
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Human Polyclonal MAD1L1 Primary Antibody for ChIP, ICC - ABIN442732
Chen, Yeh, Huang, Yeh, Juang: The spindle checkpoint protein MAD1 regulates the expression of E-cadherin and prevents cell migration. in Oncology reports 2011
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MAD1 (show MXD1 Antibodies) and Proto-Oncogene (show RAB1A Antibodies) Proteins c-myc (show MYC Antibodies) reciprocally regulate ribosomal DNA transcription, providing a mechanism for coordination of ribosome biogenesis and cell growth
MAD1 (show MXD1 Antibodies) is present in mouse oocytes at all stages during the first meiosis and that it participates in spindle checkpoint during meiosis
Data show that the loss of Trrap (show TRRAP Antibodies) leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap (show TRRAP Antibodies)-mediated transcription of the mitotic checkpoint (show BUB3 Antibodies) proteins Mad1 (show MXD1 Antibodies) and Mad2 (show MXI1 Antibodies).
identified mouse Telomeric Repeat Binding Factor 1 (Trf1 (show TERF1 Antibodies)) as a protein that interacts directly with the spindle checkpoint protein Mad1 (show MXD1 Antibodies) and the mitotic kinase Nek2 (show NEK2 Antibodies)
Together these data demonstrate that the MYC (show MYC Antibodies)-antagonist MAD1 (show MXD1 Antibodies) and cyclin-dependent kinase inhibitor p27(Kip1 (show CDKN1B Antibodies)) cooperate to regulate the self-renewal and differentiation of HSCs in a context-dependent manner.
the simultaneous knockdown of p18 (show CDKN2C Antibodies), p27 (show CDKN1B Antibodies) and MAD1 (show MXD1 Antibodies) with a medium of only stem cell factor (show KITLG Antibodies) can induce long-term culture-initiating cell expansion despite the loss of engraftment ability
MAD1L1 positive expression may be associated with tumour progression and metastasis in small-cell lung cancer (SCLC) and may thus serve as a new biomarker for prognosis in these patients.
In this review, we highlight a novel Mad1 role in chromosome alignment, which is the first conserved mechanism that links the spindle assembly checkpoint and kinesin-mediated chromosome gliding.
MAD1L1 Arg558His and MAD2L1 (show MAD2L1 Antibodies) Leu84Met interaction with smoking increase the risk of colorectal cancer
MAD1L1 rs12666575 polymorphism may play a protective role against schizophrenia (SCZ) in the Chinese population. rs12666575 may be associated with general psychopathology and thought disturbance in SCZ patients.
We also show that replication perturbations result in relocalization of MAD1 (show MXD1 Antibodies)/MAD2 (show MAD2L1 Antibodies) in human cells, suggesting that the role of SAC (show ADCY10 Antibodies) in DNA repair is conserved.
Mad1 (show MXD1 Antibodies) has a role in secretion and cell migration.
MAD1 (show MXD1 Antibodies) kinetochore localization dictates the spindle assembly checkpoint in metaphase.
This article reviews Mad1 (show MXD1 Antibodies) and Mad2 (show MAD2L1 Antibodies) - structural and functional relationship with implication in genetic diseases, specifically in cancer. [review]
Mad1 (show MXD1 Antibodies) is required for mitotic arrest even when C-Mad2 (show MAD2L1 Antibodies) is artificially recruited to kinetochores. The C-terminal globular domain of Mad1 (show MXD1 Antibodies) and conserved residues in this region are required for this unexpected function of Mad1 (show MXD1 Antibodies).
An important role of ATM (show ATM Antibodies)-mediated Mad1 (show MXD1 Antibodies) Serine 214 phosphorylation in mitosis.
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.
MAD1-like protein 1
, mitotic arrest deficient 1-like 1
, mitotic arrest deficient 1-like protein 1
, mitotic spindle assembly checkpoint protein MAD1
, mitotic checkpoint MAD1 protein homolog
, mitotic-arrest deficient 1, yeast, homolog-like 1
, tax-binding protein 181
, tumor protein p53 inducible protein 9