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MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Additionally we are shipping MAD2L1 Antibodies (137) and MAD2L1 Proteins (8) and many more products for this protein.
Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.
TRAP1 (show TRAP1 ELISA Kits) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (show TRAP1 ELISA Kits)/TBP7 (show PSMC4 ELISA Kits) quality control of CDK1 (show CDK1 ELISA Kits) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.
Thes authors show that p31 (show ATP6V1E1 ELISA Kits)(comet) binding to the TRIP13 (show TRIP13 ELISA Kits) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (show TRIP13 ELISA Kits) "pore loops", which then unfold MAD2 in the presence of ATP.
catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (show BUB3 ELISA Kits) complex assembly
in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (show AURKB ELISA Kits).
Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI (show BGN ELISA Kits)-DLBCL. Mad2 overexpression indicated a poor DFS (show FST ELISA Kits).
interactions between Mad2 and H3K4 regulate resolution of the spindle assembly checkpoint by limiting closed Mad2 availability for Cdc20 (show CDC20 ELISA Kits) inhibition.
we showed that BubR1 (show BUB1B ELISA Kits) and Mad2 are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity.
Studied the folding/unfolding process of the open and closed conformers of human Mad2.
MAD1L1 (show MAD1L1 ELISA Kits) Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer
Mad2 (show MXI1 ELISA Kits)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.
reduced MAD2 (show MXI1 ELISA Kits) levels attenuate the apoptotic response to mis (show AMH ELISA Kits)-segregating sex chromosomes and allow the formation of aneuploid sperm.
p31comet-induced cell death is mediated by interactions with Mad2 (show MXI1 ELISA Kits)
study shows that Mad2 (show MXI1 ELISA Kits) is a novel substrate for CCP6 (show AGBL4 ELISA Kits) in megakaryocytes; Mad2 (show MXI1 ELISA Kits) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis
Exacerbating chromosome missegregation in CENP-E (show CENPE ELISA Kits)+/- mice by reducing levels of another mitotic checkpoint component (show BUB3 ELISA Kits), Mad2 (show MXI1 ELISA Kits), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
Mad2 (show MXI1 ELISA Kits) is also repressed by p53 (show TP53 ELISA Kits) and its upregulation is required for chromosome instability in a p53 (show TP53 ELISA Kits) mutant tumor model
Data show that Mad2 (show MXI1 ELISA Kits) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (show APEX1 ELISA Kits) inhibitor in vitro.
Pcid2 (show PCID2 ELISA Kits) is essential for B cell survival through the regulation of MAD2 (show MXI1 ELISA Kits) expression during B cell differentiation
tumours that experience transient Mad2 (show MXI1 ELISA Kits) overexpression and consequent chromosome instability recur at markedly elevated rates
a functional Mad2 (show MXI1 ELISA Kits)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
, MAD2-like protein 1
, mitotic arrest deficient 2-like protein 1
, mitotic arrest deficient, yeast, homolog-like 1
, mitotic spindle assembly checkpoint protein MAD2A
, MAD2 (mitotic arrest deficient, homolog)-like 1
, MAD2-like 1
, spindle assembly checkpoint protein Mad2
, MAD2 mitotic arrest deficient-like 1
, MAD2 mitotic arrest deficient-like 1 (yeast)