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The protein encoded by MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Additionally we are shipping MAD2 Mitotic Arrest Deficient-Like 2 (Yeast) Antibodies (46) and many more products for this protein.
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This study demonstrates using super-resolution microscopy that numerous MAD2L2 microfoci are exclusively associated with euchromatin, similar to other factors of the DNA damage response. In the absence of MAD2L2 the amount of heterochromatin demarcated by H3K9me2 was significantly increased.
Increased gonadotropins caused by the absence of functional oocytes and accumulation of DNA damage in cells caused by the lack of repair function could be responsible for the development and progression of ovarian tumors in the Rev7 mutant mouse.
the Mad2l2 (MAD2B, Rev7) gene product is not only required by PGCs, but also by pluripotent embryonic stem cells (ESCs (show NR2E3 Proteins)), depending on the growth conditions.
results reveal an unexpected crucial function of REV7 downstream of 53BP1 in coordinating pathological DSB repair pathway choices in BRCA1-deficient cells
that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression
These results demonstrated that Rev7 is essential in resolving the replication stalls caused by DNA damage during S phase.
The function of Mad2l2 is essential in PGCs, and thus of high relevance for fertility
Rev7 is essential for PGC (show PGC Proteins) maintenance by prevention of apoptotic cell death in the mouse.
identification of the Rev7 binding surface of the Rev1 C-terminal domain
We have successfully isolated Xenopus laevis Mad2B and PRCC (show PRCC Proteins) cDNAs, so the well-established animal model Xenopus laevis can be used as a powerful system to study in detail the role of xPRCC (show PRCC Proteins) and xMad2B in the intricate processes of cell cycle control.
structure-based interaction analyses revealed an unprecedented mechanism involving CAMP's WK motif. Surprisingly, in one of the crystal forms, the MAD2L2-CAMP complex formed a dimeric structure in which the C-terminal region of MAD2L2 was swapped and adopted an immature structure
REV7 is a previously undescribed FA gene, which we term FANCV
Knockdown of REV7 inhibited the migration, invasion, and epithelial-mesenchymal transition (EMT (show ITK Proteins)) of breast cancer cells. Meanwhile, overexpression of REV7 promoted the migration, invasion, and EMT (show ITK Proteins) of breast cancer cells.
hMAD2 also binds to the hREV7-binding sequence in hREV3, whereas hMAD2 does not bind to a similar sequence in ADAM9 (show ADAM9 Proteins) or ELK-1 (show ELK1 Proteins) and hREV7 does not bind to the hMAD2-binding sequence in hMAD1 or hCDC20.
data establish MAD2L2 as a crucial contributor to the control of DNA repair activity by 53BP1 that promotes NHEJ by inhibiting 5' end resection downstream of RIF1
Rev7 is essential for mutagenesis and S phase progression in UV-irradiated fibroblasts.
These findings indicate that depletion of REV7 enhances sensitivity to cisplatin treatment in ovarian clear cell carcinoma (CCC), suggesting that REV7 is a candidate molecular target in CCC management.
MAD2L2 helps to ensure a robustly bistable switch between APC (show APC Proteins)/C(CDC20 (show CDC20 Proteins)) and APC (show APC Proteins)/C(CDH1 (show CDH1 Proteins)) during the metaphase-to-anaphase transition, thereby contributing to mitotic fidelity.
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
MAD2-like protein 2
, Mitotic arrest deficient 2-like protein 2
, mitotic spindle assembly checkpoint protein MAD2B
, MAD2 homolog
, mitotic arrest deficient 2-like protein 2
, Mitotic arrest defective protein 2B
, MAD2 (mitotic arrest deficient, yeast, homolog)-like 2
, REV7 homolog
, mitotic arrest deficient homolog-like 2
, polymerase (DNA-directed), zeta 2, accessory subunit