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Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Additionally we are shipping MAGE-Like 2 Antibodies (43) and MAGE-Like 2 Proteins (2) and many more products for this protein.

list all ELISA KIts Gene Name GeneID
Anti-Human MAGEL2 MAGEL2 54551
Anti-Rat MAGEL2 MAGEL2 679875
Anti-Mouse MAGEL2 MAGEL2 27385
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More ELISA Kits for MAGE-Like 2 Interaction Partners

Human MAGE-Like 2 (MAGEL2) interaction partners

  1. A similar pro (show LEP ELISA Kits)gressive loss of leptin sensitivity caused by loss of MAGEL2 in children with Prader-Willi s (show LEP ELISA Kits)yndrome could ex (show POMC ELISA Kits)plain the delayed onset of increased appetite and weight gain in this complex disorder.

  2. We find that MAGE-A2 interacts with MDM2 (show MDM2 ELISA Kits) via the N-terminal p53 (show TP53 ELISA Kits)-binding pocket and the RING finger (show PCGF1 ELISA Kits) domain of MDM2 (show MDM2 ELISA Kits) that is required for homo/hetero-dimerization and for E2 ligase interaction.

  3. Truncating Mutations of MAGEL2, a Gene within the Prader-Willi Locus, Are Responsible for Severe Arthrogryposis.

  4. Consistent with increased cell death, the induced loss of MAGEA2 expression correlated with increased caspase 3 (show CASP3 ELISA Kits)/7 activity, BCL2 (show BCL2 ELISA Kits)/BAX (show BAX ELISA Kits) ratio and TUNEL signal.

  5. MAGEA2 has a critical role in the development of tamoxifen-resistant breast cancer

  6. MAGEL2 is a new gene causing complex autism spectrum disorder and MAGEL2 loss of function can contribute to several aspects of the Prader-Willi syndrome phenotype.

  7. These findings provide a cellular and molecular function for MAGE-L2-TRIM27 (show RFP ELISA Kits) in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex.

  8. MageA2 interferes with p53 (show TP53 ELISA Kits) acetylation at PML (show PML ELISA Kits)-nuclear bodies (NBs (show NBN ELISA Kits)) and with PMLIV-dependent activation of p53 (show TP53 ELISA Kits).

  9. Report MAGEA1 (show MAGEA1 ELISA Kits)-A6 expression in sputum suggests presence of lung cancer cells or precancerous cells.

  10. These data suggest that MAGEA2 is differentially expressed in HNSCC and functions, in part, through the p53 (show TP53 ELISA Kits) pathway by increasing cellular proliferation and abrogating cell cycle arrest.

Pig (Porcine) MAGE-Like 2 (MAGEL2) interaction partners

  1. Moreover, -712C>G and -708T>C had significant effects on MAGEL2 transcription and placental efficiency

  2. Imprinting analysis showed that NDN (show NDN ELISA Kits) and MAGEL2 are paternally expressed in all tissues of pig where the genes were expressed as in human and mouse.

Mouse (Murine) MAGE-Like 2 (MAGEL2) interaction partners

  1. Normal leptin (show LEP ELISA Kits) responses were found in Magel2-null mice up to 4 weeks of age, but the proportion of leptin (show LEP ELISA Kits)-responsive POMC (show POMC ELISA Kits) neurons was reduced in 6-week-old Magel2-null mice.

  2. Magel2 inactivation induces a deficit in social recognition and social interaction and a reduced learning ability in adult male mice.

  3. This neural defect, together with increased fat mass, blunted circadian rhythm, and growth hormone (show GH1 ELISA Kits) response pathway defects that are also linked to loss of MAGEL2, could contribute to the hyperphagia and obesity that are hallmarks of this disorder.

  4. This study demonstrated that Magel2-null mice have abnormalities of hypothalamic endocrine axes that recapitulate phenotypes in Prader-Willi syndrome.

  5. Magel2-deficient mouse with 50% neonatal mortality had an altered onset of suckling activity and subsequent impaired feeding.

  6. Magel2 gene is imprinted, with preferential expression from the paternal allele in mouse and human.

  7. role of the circadian rhythm output gene Magel2 in brain structure and behavior

  8. necdin (show NDN ELISA Kits) and MAGE-G1 (show NDNL2 ELISA Kits) target both E2F1 (show E2F1 ELISA Kits) and p75 (show NGFR ELISA Kits) to regulate cell viability during brain development.

  9. Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome

  10. The robust rhythmicity of Magel2 expression in the SCN (show SRI ELISA Kits) and the altered behavioral rhythmicity of null mice reveal Magel2 to be a clock-controlled circadian output gene whose disruption results in some of the phenotypes characteristic of PWS.

MAGE-Like 2 (MAGEL2) Antigen Profile

Antigen Summary

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.

Gene names and symbols associated with MAGE-Like 2 (MAGEL2) ELISA Kits

  • MAGE-like 2 (MAGEL2) antibody
  • MAGE-like protein 2 (LOC100343334) antibody
  • MAGE-like 2 (Magel2) antibody
  • melanoma antigen family A, 2 (MAGEA2) antibody
  • melanoma antigen, family L, 2 (Magel2) antibody
  • CT1.2 antibody
  • Mage-l2 antibody
  • MAGE2 antibody
  • MAGEA2A antibody
  • MAGEL2 antibody
  • NDNL1 antibody
  • nM15 antibody
  • ns7 antibody

Protein level used designations for MAGE-Like 2 (MAGEL2) ELISA Kits

MAGE-like 2 , MAGE-like protein 2 , necdin-like protein 1 , protein nM15 , melanoma antigen-like gene 2 , melanoma antigen, family L, 2 , MAGE-2 antigen , cancer/testis antigen 1.2 , cancer/testis antigen family 1, member 2 , melanoma antigen 2 , melanoma-associated antigen 2 , necdin-like 1 , protein nS7

719760 Macaca mulatta
100343334 Oryctolagus cuniculus
54551 Homo sapiens
100154924 Sus scrofa
538665 Bos taurus
679875 Rattus norvegicus
4101 Homo sapiens
27385 Mus musculus
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